Maternal urinary concentrations of bisphenol A during pregnancy are associated with global DNA methylation in cord blood of newborns in the 'NELA' birth cohort
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| Titel: | Maternal urinary concentrations of bisphenol A during pregnancy are associated with global DNA methylation in cord blood of newborns in the 'NELA' birth cohort |
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| Autoren: | Navarro-Lafuente, Fuensanta, Adoamnei, Evdochia, Arense-Gonzalo, Julian J, Prieto-Sanchez, María T, Sanchez-Ferrer, Maria L, Parrado, Antonio, Fernandez, Mariana F, Suarez, Beatriz, Lopez-Acosta, Antonia, Sanchez-Guillamon, Antonio, Garcia-Marcos, Luis, Morales, Eva, Mendiola, Jaime, Torres-Cantero, Alberto M, NELA Study group |
| Weitere Verfasser: | Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Science, Innovation and Universities, Fondos FEDER, Fundación Séneca, Agencia de Ciencia y Tecnología Región de Murcia |
| Quelle: | RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía instname |
| Verlagsinformationen: | Elsevier BV, 2022. |
| Publikationsjahr: | 2022 |
| Schlagwörter: | Male, Disruptores endocrinos, Embarazo, Perinatal exposures, Endocrine Disruptors, LINE-1, Bisphenol A, Phenols, Cohorte de nacimiento, Pregnancy, Recién nacido, Humans, Benzhydryl Compounds, Masculino, Endocrine disruptors, Asma, DNA methylation, Compuestos de Bencidrilo, Infant, Newborn, Femenino, DNA Methylation, Fetal Blood, Asthma, Sangre fetal, Fenoles, Exposición materna, Maternal Exposure, Birth Cohort, Female, Metilación de ADN |
| Beschreibung: | Endocrine disrupting chemicals (EDCs) set a public health risk through disruption of normal physiological processes. The toxicoepigenetic mechanisms of developmental exposure to common EDCs, such as bisphenol A (BPA), are poorly known. The present study aimed to evaluate associations between perinatal maternal urinary concentrations of BPA, bisphenol S (BPS) and bisphenol F (BPF) and LINE-1 (long interspersed nuclear elements) and Alu (short interspersed nuclear elements, SINEs) DNA methylation levels in newborns, as surrogate markers of global DNA methylation. Data come from 318 mother-child pairs of the `Nutrition in Early Life and Asthma´ (NELA) birth cohort. Urinary bisphenol concentration was measured by dispersive liquid-liquid microextraction and ultrahigh performance liquid chromatography with tandem mass spectrometry detection. DNA methylation was quantitatively assessed by bisulphite pyrosequencing on 3 LINEs and 5 SINEs. Unadjusted linear regression analyses showed that higher concentration of maternal urinary BPA in 24th week's pregnancy was associated with an increase in LINE-1 methylation in all newborns (p = 0.01) and, particularly, in male newborns (p = 0.03). These associations remained in full adjusted models [beta = 0.09 (95 % CI = 0.03; 0.14) for all newborns; and beta = 0.10 (95 % CI = 0.03; 0.17) for males], including a non-linear association for female newborns as well (p-trend = 0.003). No associations were found between maternal concentrations of bisphenol and Alu sequences. Our results suggest that exposure to environmental levels of BPA may be associated with a modest increase in LINE-1 methylation -as a relevant marker of epigenomic stability- during human fetal development. However, any effects on global DNA methylation are likely to be small, and of uncertain biological significance. |
| Publikationsart: | Article |
| Dateibeschreibung: | application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| Sprache: | English |
| Zugangs-URL: | http://hdl.handle.net/10668/22512 https://hdl.handle.net/10668/22512 |
| Rights: | CC BY NC |
| Dokumentencode: | edsair.dedup.wf.002..a7106b6d76f2deb3bc22d5bba1f37f3c |
| Datenbank: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstract: | Endocrine disrupting chemicals (EDCs) set a public health risk through disruption of normal physiological processes. The toxicoepigenetic mechanisms of developmental exposure to common EDCs, such as bisphenol A (BPA), are poorly known. The present study aimed to evaluate associations between perinatal maternal urinary concentrations of BPA, bisphenol S (BPS) and bisphenol F (BPF) and LINE-1 (long interspersed nuclear elements) and Alu (short interspersed nuclear elements, SINEs) DNA methylation levels in newborns, as surrogate markers of global DNA methylation. Data come from 318 mother-child pairs of the `Nutrition in Early Life and Asthma´ (NELA) birth cohort. Urinary bisphenol concentration was measured by dispersive liquid-liquid microextraction and ultrahigh performance liquid chromatography with tandem mass spectrometry detection. DNA methylation was quantitatively assessed by bisulphite pyrosequencing on 3 LINEs and 5 SINEs. Unadjusted linear regression analyses showed that higher concentration of maternal urinary BPA in 24th week's pregnancy was associated with an increase in LINE-1 methylation in all newborns (p = 0.01) and, particularly, in male newborns (p = 0.03). These associations remained in full adjusted models [beta = 0.09 (95 % CI = 0.03; 0.14) for all newborns; and beta = 0.10 (95 % CI = 0.03; 0.17) for males], including a non-linear association for female newborns as well (p-trend = 0.003). No associations were found between maternal concentrations of bisphenol and Alu sequences. Our results suggest that exposure to environmental levels of BPA may be associated with a modest increase in LINE-1 methylation -as a relevant marker of epigenomic stability- during human fetal development. However, any effects on global DNA methylation are likely to be small, and of uncertain biological significance. |
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