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On the origins and variation of nucleotide skews of archaeal genomes.

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Titel: On the origins and variation of nucleotide skews of archaeal genomes.
Autoren: Paravel, Adrien, Mottez, Clémence, Puech, Romain, Flament, Didier, Becker, Hubert F., Myllykallio, Hannu
Quelle: Frontiers in Microbiology; 2026, p1-9, 9p
Schlagwörter: ARCHAEBACTERIA, DNA repair, MUTAGENS, GENETIC code, GENOMES
Abstract: We have used nucleotide skews as the proxy to understand the evolution of archaeal genomes. Our genome-wide studies using substantial datasets suggest that translational selection and the nature of the genetic code are universally conserved determinants of asymmetric guanine and cytosine distributions. We propose that in the case of the majority of bacterial chromosomes, mutational processes and/or DNA repair also result in the strand-specific nucleotide skews. This is in stark contrast to what we observe for archaeal chromosomes and plasmids, and reveals that archaea have a greatly reduced ability to create mutations and/or repair DNA damage in a strand-specific manner. We suggest that in the future, the described computational and statistical approach will help to understand the evolutionary dynamics of the archaeal chromosomes through the tree of life. [ABSTRACT FROM AUTHOR]
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Datenbank: Biomedical Index
Beschreibung
Abstract:We have used nucleotide skews as the proxy to understand the evolution of archaeal genomes. Our genome-wide studies using substantial datasets suggest that translational selection and the nature of the genetic code are universally conserved determinants of asymmetric guanine and cytosine distributions. We propose that in the case of the majority of bacterial chromosomes, mutational processes and/or DNA repair also result in the strand-specific nucleotide skews. This is in stark contrast to what we observe for archaeal chromosomes and plasmids, and reveals that archaea have a greatly reduced ability to create mutations and/or repair DNA damage in a strand-specific manner. We suggest that in the future, the described computational and statistical approach will help to understand the evolutionary dynamics of the archaeal chromosomes through the tree of life. [ABSTRACT FROM AUTHOR]
ISSN:1664302X
DOI:10.3389/fmicb.2026.1727296