View in EDS

Bioactive Content, Antioxidant and Lactogenic Effects of Ethanol Extract of Gymnema sylvestre Leaves.

Saved in:
Bibliographic Details
Title: Bioactive Content, Antioxidant and Lactogenic Effects of Ethanol Extract of Gymnema sylvestre Leaves.
Authors: Karnasih, I. Gusti, Sasmito, Lulut, Fakhriza, Ilmah, Sari, Rika Mahardika, Destiawan, Rian Anggia, Hidayati, Sholihatil
Source: Tropical Journal of Natural Product Research; Jan2026, Vol. 10 Issue 1, p6684-6690, 7p
Abstract: Gymnema sylvestre leaves have been empirically used, especially by the local Madurese, to increase breast milk production or as a galactagogue. However, scientific evidence supporting this use remains limited. Hormones, including oxytocin and prolactin are fundamental mediators of mammary morphogenesis and lactogenesis. This study aims to investigate the lactogenic effect of Gymnema sylvestre leaves in postpartum rats. The in vitro antioxidant capacity of the extract was assessed using the the DPPH method, while the lactogenic effect, including oxytocin and prolactin levels, were evaluated in vivo in postpartum rats using the ELISA method. A total of 30 postpartum rats were divided into 5 groups: negative, positive, and treatment groups receiving GSLE doses of 25, 50, and 100 mg/kg BW, treated for 14 days. The results showed GSLE contains bioactive compounds, including flavonoids (89.2 ± 0.09 µg QE/mg), phenolic (53.9 ± 0.01 µg GAE/mg) and tannins (40.7 ± 0.01 µg GAE/mg). Antioxidant activity showed an IC50 value of 44.10 ± 3.12 µg/mL. The results of the lactogenic effect indicated that GSLE administration increased oxytocin and prolactin levels (p<0.05). Oxytocin levels increased significantly at the GSLE dose of 50 mg/kg BW on day 7. Prolactin levels were significantly increased by GSLE administration at doses of 25, 50, and 100 mg/kg BW compared to the negative control group. The antioxidant and lactogenic activities suggest that GSLE has the potential for further development as a galactogogue. [ABSTRACT FROM AUTHOR]
Copyright of Tropical Journal of Natural Product Research is the property of University of Benin, Faculty of Pharmacy and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Biomedical Index
Description
Abstract:Gymnema sylvestre leaves have been empirically used, especially by the local Madurese, to increase breast milk production or as a galactagogue. However, scientific evidence supporting this use remains limited. Hormones, including oxytocin and prolactin are fundamental mediators of mammary morphogenesis and lactogenesis. This study aims to investigate the lactogenic effect of Gymnema sylvestre leaves in postpartum rats. The in vitro antioxidant capacity of the extract was assessed using the the DPPH method, while the lactogenic effect, including oxytocin and prolactin levels, were evaluated in vivo in postpartum rats using the ELISA method. A total of 30 postpartum rats were divided into 5 groups: negative, positive, and treatment groups receiving GSLE doses of 25, 50, and 100 mg/kg BW, treated for 14 days. The results showed GSLE contains bioactive compounds, including flavonoids (89.2 ± 0.09 µg QE/mg), phenolic (53.9 ± 0.01 µg GAE/mg) and tannins (40.7 ± 0.01 µg GAE/mg). Antioxidant activity showed an IC<subscript>50</subscript> value of 44.10 ± 3.12 µg/mL. The results of the lactogenic effect indicated that GSLE administration increased oxytocin and prolactin levels (p<0.05). Oxytocin levels increased significantly at the GSLE dose of 50 mg/kg BW on day 7. Prolactin levels were significantly increased by GSLE administration at doses of 25, 50, and 100 mg/kg BW compared to the negative control group. The antioxidant and lactogenic activities suggest that GSLE has the potential for further development as a galactogogue. [ABSTRACT FROM AUTHOR]
ISSN:26160684
DOI:10.26538/tjnpr/v10i1.35