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Meta-Research in Neuroscience: An Urgent Call to Strengthen the Reliability and Translation of Knowledge into Evidence-Based Neurological Practice.

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Název: Meta-Research in Neuroscience: An Urgent Call to Strengthen the Reliability and Translation of Knowledge into Evidence-Based Neurological Practice.
Autoři: Lozada-Martinez, Ivan David, Delgado Arias, Luis Miguel, Perea Rojas, Diana Marcela, Rojas Torres, Indiana Luz
Zdroj: Journal of Clinical Medicine; Dec2025, Vol. 14 Issue 23, p8552, 11p
Témata: NEUROSCIENCES, REPRODUCIBLE research, EVIDENCE-based medicine, UNIVERSITY research, RESEARCH evaluation, RESEARCH methodology, RELIABILITY in engineering
Abstrakt: Despite the exponential expansion of neuroscience over recent decades, the field has rarely examined the rigor, transparency, and reproducibility of its own evidence base (research on research). Through a brief systematic exploration of the Scopus database, we identified more than 370,000 neuroscience articles, yet only 15 explicitly addressed meta-research questions, representing a mere 0.004% of the total literature. These few studies were concentrated in high-income countries and limited mainly to neuroimaging and methodological reporting, leaving major subfields such as neuropharmacology, neuropathology, and neuroendocrinology virtually unexplored. This striking imbalance reveals a systemic absence of evidence self-assessment and highlights how neuroscience has advanced without adequate reflection on the validity and translatability of its findings. The lack of meta-research weakens the reliability of neuroscientific evidence, slows the development of shared reporting standards, and risks compromising its translation into evidence-based neurological practice. Strengthening global collaboration, fostering reflexivity, and integrating meta-research into neuroscience are urgent steps toward ensuring that the knowledge generated in laboratories and trials truly supports trustworthy, reproducible, and clinically meaningful clinical healthcare in neurological sciences. [ABSTRACT FROM AUTHOR]
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Databáze: Biomedical Index
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Abstrakt:Despite the exponential expansion of neuroscience over recent decades, the field has rarely examined the rigor, transparency, and reproducibility of its own evidence base (research on research). Through a brief systematic exploration of the Scopus database, we identified more than 370,000 neuroscience articles, yet only 15 explicitly addressed meta-research questions, representing a mere 0.004% of the total literature. These few studies were concentrated in high-income countries and limited mainly to neuroimaging and methodological reporting, leaving major subfields such as neuropharmacology, neuropathology, and neuroendocrinology virtually unexplored. This striking imbalance reveals a systemic absence of evidence self-assessment and highlights how neuroscience has advanced without adequate reflection on the validity and translatability of its findings. The lack of meta-research weakens the reliability of neuroscientific evidence, slows the development of shared reporting standards, and risks compromising its translation into evidence-based neurological practice. Strengthening global collaboration, fostering reflexivity, and integrating meta-research into neuroscience are urgent steps toward ensuring that the knowledge generated in laboratories and trials truly supports trustworthy, reproducible, and clinically meaningful clinical healthcare in neurological sciences. [ABSTRACT FROM AUTHOR]
ISSN:20770383
DOI:10.3390/jcm14238552