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A study of Differentiation of Liver Metastases and Primary Hepatic Malignancies Using Diffusion-Weighted MRI and ADC Measurements in a tertiary hospital in Central India.

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Název: A study of Differentiation of Liver Metastases and Primary Hepatic Malignancies Using Diffusion-Weighted MRI and ADC Measurements in a tertiary hospital in Central India.
Autoři: Tekam, Sharda, Yerme, Pravin, Gandhi, Pranay
Zdroj: European Journal of Cardiovascular Medicine; Nov2025, Vol. 15 Issue 11, p47-56, 10p
Témata: LIVER metastasis, DIFFUSION magnetic resonance imaging, LIVER cancer, DIAGNOSTIC services, CHOLANGIOCARCINOMA, HEPATOCELLULAR carcinoma, PATIENT care, DIFFUSION measurements
Abstrakt: Background: Purpose: To quantitatively assess the diagnostic value of DWI and ADC mapping in distinguishing liver metastases from primary hepatic malignancies (hepatocellular carcinoma and cholangiocarcinoma). Methods: DW-MRI data from patients with biopsy-proven malignant liver lesions were retrospectively analyzed. ADC values of metastatic lesions were compared to those of HCC and cholangiocarcinoma using t-tests and ROC analysis. Results: Mean ADC of metastases (0.81±0.19×10−3 mm2/s0.81±0.19×10−3mm2/s) was significantly lower than that of HCC (1.03±0.23×10−3 mm2/s1.03±0.23×10−3mm2/s), p=0.01. ROC analysis produced an AUC of 0.83 and an optimal cutoff of 0.90×10−3 mm2/s0.90×10−3mm2/s for identifying metastases Conclusion: DW-MRI ADC quantification is a practical adjunct for differentiating metastatic lesions from primary hepatic cancers, supporting more precise patient management. [ABSTRACT FROM AUTHOR]
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Databáze: Biomedical Index
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Abstrakt:Background: Purpose: To quantitatively assess the diagnostic value of DWI and ADC mapping in distinguishing liver metastases from primary hepatic malignancies (hepatocellular carcinoma and cholangiocarcinoma). Methods: DW-MRI data from patients with biopsy-proven malignant liver lesions were retrospectively analyzed. ADC values of metastatic lesions were compared to those of HCC and cholangiocarcinoma using t-tests and ROC analysis. Results: Mean ADC of metastases (0.81±0.19×10−3 mm2/s0.81±0.19×10−3mm2/s) was significantly lower than that of HCC (1.03±0.23×10−3 mm2/s1.03±0.23×10−3mm2/s), p=0.01. ROC analysis produced an AUC of 0.83 and an optimal cutoff of 0.90×10−3 mm2/s0.90×10−3mm2/s for identifying metastases Conclusion: DW-MRI ADC quantification is a practical adjunct for differentiating metastatic lesions from primary hepatic cancers, supporting more precise patient management. [ABSTRACT FROM AUTHOR]
ISSN:20424884