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Determining Reference Intervals and Median Blood Creatinine Levels in Children from Three Different Regional Populations.

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Název: Determining Reference Intervals and Median Blood Creatinine Levels in Children from Three Different Regional Populations.
Autoři: Marpaung, Ferdy Royland, Notobroto, Hari Basuki, Prasetyo, Risky Vitria, Santoso, Djoko, Cavalier, Etienne, Aryati, Aryati
Zdroj: Journal of Clinical Medicine; 8/1/2025, Vol. 14 Issue 15, p5373, 11p
Témata: CREATININE, REFERENCE values, SCHOOL children, AGE groups, BIOMARKERS, PEDIATRICS, CLINICAL decision making, KIDNEY physiology
Abstrakt: Background: A critical gap exists in the current literature regarding pediatric-specific creatinine reference data. This study established age- and sex-stratified reference intervals and a corresponding median (Qcr) model for serum creatinine in children, providing a crucial foundation for improved diagnostic accuracy and clinical decision-making in this vulnerable population. Methods: A total of 9090 children (52.38% males and 47.65% females) who were getting regular check-ups at clinical laboratories in three regions were included in this study to establish Qcr serum and reference ranges for creatinine concentration. Results: The reference values and serum Qcr creatinine were established for children based on age and sex. Both males and females experience an incremental increase in creatinine levels with advancing age. In addition, significant differences were seen across the three areas in other age groups (p < 0.05). Conclusions: These newly established, age- and sex-stratified reference and Qcr values provide a critical resource for clinical laboratories, empowering clinicians to more accurately assess pediatric renal function and enabling more precise, individualized care for children with renal concerns. [ABSTRACT FROM AUTHOR]
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Databáze: Biomedical Index
Popis
Abstrakt:Background: A critical gap exists in the current literature regarding pediatric-specific creatinine reference data. This study established age- and sex-stratified reference intervals and a corresponding median (Qcr) model for serum creatinine in children, providing a crucial foundation for improved diagnostic accuracy and clinical decision-making in this vulnerable population. Methods: A total of 9090 children (52.38% males and 47.65% females) who were getting regular check-ups at clinical laboratories in three regions were included in this study to establish Qcr serum and reference ranges for creatinine concentration. Results: The reference values and serum Qcr creatinine were established for children based on age and sex. Both males and females experience an incremental increase in creatinine levels with advancing age. In addition, significant differences were seen across the three areas in other age groups (p < 0.05). Conclusions: These newly established, age- and sex-stratified reference and Qcr values provide a critical resource for clinical laboratories, empowering clinicians to more accurately assess pediatric renal function and enabling more precise, individualized care for children with renal concerns. [ABSTRACT FROM AUTHOR]
ISSN:20770383
DOI:10.3390/jcm14155373