View in EDS

In Silico Study of Java Cardamom (Amomum compactum) Fruit Derivative Compounds as Antihyperuricemia.

Saved in:
Bibliographic Details
Title: In Silico Study of Java Cardamom (Amomum compactum) Fruit Derivative Compounds as Antihyperuricemia.
Authors: Nofriyaldi, Ali, Rahmawati, Nita Astuti, Nurzaman, Mochamad H., Fadilah, Nitya N., Isnaeni, Selvy
Source: Tropical Journal of Natural Product Research; Jul2025, Vol. 9 Issue 7, p3026-3030, 5p
Subject Terms: XANTHINE oxidase, AMINO acid residues, BINDING energy, DISEASE complications, URIC acid
Abstract: Hyperuricemia is a condition where the level of uric acid in the blood exceeds the threshold, which can cause gout and can be a complication of kidney disease and cancer. PDB 3NVW is a xanthine oxidase protein, the target for antihyperuricemia activity, and the main target of allopurinol for treating gout. This study aimed to identify the active ingredients in cardamom fruit that can potentially prevent hyperhyperuricemia using in silico approach. Testing was carried out using a series of processes, including the search for compounds from cardamom fruit, toxicity and pharmacokinetic screening, drug scan, molecular docking, docking visualization, and molecular dynamics. The results of the in silico test showed that the compound 3-Cyclohexene-1-methanol has a low binding energy value of -5.36 kcal/mol and an inhibition constant of 117 µM, and has amino acid residues similar to allopurinol as a reference drug, namely ARG880, GLU802, and PHE914. The low binding energy value indicates that the compound 3-Cyclohexene-1-methanol is better and more potent as an antihyperuricemia than the reference drug. [ABSTRACT FROM AUTHOR]
Copyright of Tropical Journal of Natural Product Research is the property of University of Benin, Faculty of Pharmacy and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Biomedical Index
Description
Abstract:Hyperuricemia is a condition where the level of uric acid in the blood exceeds the threshold, which can cause gout and can be a complication of kidney disease and cancer. PDB 3NVW is a xanthine oxidase protein, the target for antihyperuricemia activity, and the main target of allopurinol for treating gout. This study aimed to identify the active ingredients in cardamom fruit that can potentially prevent hyperhyperuricemia using in silico approach. Testing was carried out using a series of processes, including the search for compounds from cardamom fruit, toxicity and pharmacokinetic screening, drug scan, molecular docking, docking visualization, and molecular dynamics. The results of the in silico test showed that the compound 3-Cyclohexene-1-methanol has a low binding energy value of -5.36 kcal/mol and an inhibition constant of 117 µM, and has amino acid residues similar to allopurinol as a reference drug, namely ARG880, GLU802, and PHE914. The low binding energy value indicates that the compound 3-Cyclohexene-1-methanol is better and more potent as an antihyperuricemia than the reference drug. [ABSTRACT FROM AUTHOR]
ISSN:26160684
DOI:10.26538/tjnpr/v9i7.10