Bibliographic Details
| Title: |
Carbapenem resistant Klebsiella pneumoniae in COVID-19 patients admitted in intensive care units of Zagazig University Hospitals. |
| Authors: |
Ahmed Mohamed, Tahia Mohamed, Afifi, Samir A., Hassaneen, Ahmad M., Radwan, Mona, Ateya, Rehab Mohamed |
| Source: |
Microbes & Infectious Diseases; Nov2024, Vol. 5 Issue 4, p1240-1252, 13p |
| Subject Terms: |
NOSOCOMIAL infections, COVID-19, INTENSIVE care patients, MULTIDRUG resistance, KLEBSIELLA pneumoniae |
| Abstract (English): |
Background: Continuous monitoring is crucial to detect infection by Carbapenemase-producing Klebsiella pneumoniae (CPKP) in intensive care COVID-19 patients. Aim: to evaluate the CR-KP colonization and co- infection and evaluate the antibiotic resistance pattern. Methods: A cross -sectional study was done on COVID-19 patients with CPKP infection in Zagazig University Hospitals where rectal swab samples were detected using XpertCarba-R Assay(Cepheid, Sunnyvale), while isolates from sputum, urine, and blood culture were identified phenotypically by VITEK® 2 (bioMérieux SA) and modified Hodge test while genotypically by XpertCarba-R Assay(Cepheid, Sunnyvale). Results: CPKP was found in 60 patients out of 140 patients (42.8%), with 34 CPKP identified from rectal swabs, 12 patients infected from diverse locations (blood, respiratory secretions, and urine), and 14 COVID-19 patients developing CPKP co-infection with colonization. A widespread resistance to all antibiotic classes was found on the antibiograms of CPKP isolates and the blaNDM was the most common genotype detected by preliminary PCR testing. Conclusion: Regarding CPKP infection, a continues focus should be taken when dealing with it, particularly among COVID-19 patients. The incidence of multi-drug resistance due to nosocomial infection can be decreased by the rigorous monitoring of colonized patients and expedite the infection control practices. [ABSTRACT FROM AUTHOR] |
| Abstract (Arabic): |
تتناول المقالة انتشار وأنماط مقاومة المضادات الحيوية لبكتيريا كليبسيلا الرئوية المقاومة للكاربينيم (CRKP) بين مرضى كوفيد-19 في وحدات العناية المركزة بمستشفيات جامعة الزقازيق في مصر. وجدت دراسة مقطعية أن CRKP موجودة في 60 من أصل 140 مريضًا، حيث عانى العديد منهم أيضًا من عدوى مشتركة. وأبرزت الدراسة مقاومة المضادات الحيوية الكبيرة، لا سيما تجاه الكاربينيمات، ووجود جين blaNDM. وتدعو إلى المراقبة المستمرة وتطبيق تدابير صارمة للسيطرة على العدوى لمواجهة التحديات التي تطرحها العدوى المقاومة لعدة أدوية في هذه الفئة الضعيفة، كما تناقش الآثار الأوسع للعدوى البكتيرية والفطرية المشتركة في علاج كوفيد-19. [Extracted from the article] |
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| Database: |
Biomedical Index |
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