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Sense and Response in the Cell.

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Bibliographic Details
Title: Sense and Response in the Cell.
Authors: Taxak, Shashank
Source: Journal of Drug Delivery & Therapeutics; Jul/Aug2019, Vol. 9 Issue 4, p670-675, 6p
Subject Terms: CELL physiology, CELLULAR signal transduction, CELL anatomy, SENSES, CELLS
Abstract: Almost a century ago, Paul Ehlrich proposed a concept of the ‘receptors’ as sensing components of cellular signaling pathways for the mediation of downstream response in the context of toxin action. Since then, we have come a long way in describing the signal transduction through dynamic sense & response in various domains of cell physiology studies, beyond the static ‘receptor -ligand’ mechanism. A multi-nodal characteristic of such signaling modules generates an enriched version of temporal signals responsible for a fine-tuned cellular response based on the identity and severity of stimulus. Here, we review diverse nodes of dynamic signal transduction mechanism for an efficient cellular response. [ABSTRACT FROM AUTHOR]
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Database: Biomedical Index
Description
Abstract:Almost a century ago, Paul Ehlrich proposed a concept of the ‘receptors’ as sensing components of cellular signaling pathways for the mediation of downstream response in the context of toxin action. Since then, we have come a long way in describing the signal transduction through dynamic sense & response in various domains of cell physiology studies, beyond the static ‘receptor -ligand’ mechanism. A multi-nodal characteristic of such signaling modules generates an enriched version of temporal signals responsible for a fine-tuned cellular response based on the identity and severity of stimulus. Here, we review diverse nodes of dynamic signal transduction mechanism for an efficient cellular response. [ABSTRACT FROM AUTHOR]
ISSN:22501177
DOI:10.22270/jddt.v9i4.3165