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The contribution of mycetoma grains to suboptimal disease management.

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Názov: The contribution of mycetoma grains to suboptimal disease management.
Autori: Hassan Fahal, Ahmed, Ahmed, Abdalla Osaman, El Hassan, Lamyaa, Saeed, Ali Awadallah
Zdroj: Nature Communications; 11/7/2025, Vol. 16 Issue 1, p1-10, 10p
Predmety: DISEASE management, SKIN infections, SCHOLARLY method, DISEASE relapse, MULTIDISCIPLINARY practices, TREATMENT failure, PATHOLOGICAL physiology, FUNGI
Abstrakt: A defining feature of mycetoma is the presence of grains, which are dense, compact structures composed of the causative bacterial or fungal microorganisms. These grains define clinical resistance to treatment, and the likelihood of chronicity. Understanding the molecular mechanisms underlying grain development are critical for enhancing treatment efficacy; however, important questions remain about the underlying genetic, biochemical, and structural pathways. In this Review, we discuss what is known about mycetoma grain formation, with a focus on Madurella mycetomatis, and the need for multi-disciplinary approaches to aid their clinical management and treatment. Mycetoma is a chronic, deep skin infection that is often characterised by grains. This Review discusses what is known about mycetoma grain formation, with a focus on Madurella mycetomatis, and the need for multi-disciplinary approaches to aid their clinical management and treatment. [ABSTRACT FROM AUTHOR]
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Databáza: Complementary Index
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Abstrakt:A defining feature of mycetoma is the presence of grains, which are dense, compact structures composed of the causative bacterial or fungal microorganisms. These grains define clinical resistance to treatment, and the likelihood of chronicity. Understanding the molecular mechanisms underlying grain development are critical for enhancing treatment efficacy; however, important questions remain about the underlying genetic, biochemical, and structural pathways. In this Review, we discuss what is known about mycetoma grain formation, with a focus on Madurella mycetomatis, and the need for multi-disciplinary approaches to aid their clinical management and treatment. Mycetoma is a chronic, deep skin infection that is often characterised by grains. This Review discusses what is known about mycetoma grain formation, with a focus on Madurella mycetomatis, and the need for multi-disciplinary approaches to aid their clinical management and treatment. [ABSTRACT FROM AUTHOR]
ISSN:20411723
DOI:10.1038/s41467-025-64908-8