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Successful emerging use of mepolizumab in the treatment of idiopathic chronic eosinophilic pneumonia: A case report.

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Bibliographic Details
Title: Successful emerging use of mepolizumab in the treatment of idiopathic chronic eosinophilic pneumonia: A case report.
Authors: Ząber, Julia, Wyleciał, Zuzanna
Source: Pneumon; Jul-Sep2025, Vol. 38 Issue 3, p1-6, 6p
Subject Terms: EOSINOPHILIA, INTERLEUKIN-5, BRONCHOALVEOLAR lavage, TREATMENT effectiveness, DISEASE remission, MEDICAL literature, MONOCLONAL antibodies, PULMONARY eosinophilia
Abstract: We present a case of a 65-year-old Caucasian man with a six-month history of persistent non-productive cough, weight loss, and decreased exercise tolerance. Laboratory tests performed revealed significant eosinophilia in peripheral blood. Chest computed tomography identified extensive peripheral ground-glass opacities. Diagnostic bronchoscopy showed an eosinophilicrich bronchoalveolar lavage representing 85% of the total white blood cell count, confirming the diagnosis of chronic eosinophilic pneumonia. The cause remained unknown. Our patient was treated with prednisone 40 mg/ day complicated by recurrent infections. When trying to gradually reduce the dose of prednisone, the disease relapsed. Emerging use of mepolizumab, an interleukin-5-inhibiting monoclonal antibody, was associated with improvement of the clinical condition, reduction of peripheral blood eosinophils, regression of changes in imaging tests and remission maintenance without systemic steroids. [ABSTRACT FROM AUTHOR]
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Database: Complementary Index
Description
Abstract:We present a case of a 65-year-old Caucasian man with a six-month history of persistent non-productive cough, weight loss, and decreased exercise tolerance. Laboratory tests performed revealed significant eosinophilia in peripheral blood. Chest computed tomography identified extensive peripheral ground-glass opacities. Diagnostic bronchoscopy showed an eosinophilicrich bronchoalveolar lavage representing 85% of the total white blood cell count, confirming the diagnosis of chronic eosinophilic pneumonia. The cause remained unknown. Our patient was treated with prednisone 40 mg/ day complicated by recurrent infections. When trying to gradually reduce the dose of prednisone, the disease relapsed. Emerging use of mepolizumab, an interleukin-5-inhibiting monoclonal antibody, was associated with improvement of the clinical condition, reduction of peripheral blood eosinophils, regression of changes in imaging tests and remission maintenance without systemic steroids. [ABSTRACT FROM AUTHOR]
ISSN:1105848X
DOI:10.18332/pne/210356