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Fabrication and evaluation of AMPS-based enteric-coated hydrogel beads: a promising tool for colon targeting.

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Title: Fabrication and evaluation of AMPS-based enteric-coated hydrogel beads: a promising tool for colon targeting.
Authors: Rehman, Kiran, Pervaiz, Fahad, Shoukat, Hina, Rehman, Sadia, Noreen, Sobia, Sarfraz, Muhammad, Khan, Kifayat Ullah, Ahmad, Aousaf, Ijaz, Shakeel
Source: Journal of Sol-Gel Science & Technology; Aug2025, Vol. 115 Issue 2, p822-834, 13p
Abstract: Targeted drug delivery to the colon offers a promising approach to enhance therapeutic efficacy while minimizing systemic side effects. Our goal in this study was to create a pH-responsive, crosslinked hydrogel matrix for colonic drug release under control. Hydrogels based on poly (2-acrylamido-2-methylpropanesulfonic acid) (poly (AMPS)) were created by adjusting the amounts of the crosslinker (N, N'-methylene bisacrylamide, MBA) and monomer (AMPS). The resultant solidified hydrogel was converted into hydrogel beads. Several analytical approaches were used to thoroughly analyse the hydrogel beads' structural, physicochemical, and pharmacokinetic characteristics. The existence of the intended chemical connections was confirmed by Fourier Transform Infrared Spectroscopy, and swelling investigations showed that swelling behavior was pH-dependent, with higher pH values causing more swelling. The investigation of drug entrapment efficiency revealed that nimesulide, a model drug, was effectively loaded into the hydrogel matrix. Studies on in vitro drug release showed pH-responsive and prolonged release characteristics, suggesting the possibility of specific delivery of drugs to the colon. Furthermore, the hydrogel beads' capacity to expand and their biocompatibility were confirmed by in vivo testing in rabbit models, where no acute toxicity was noted. The results of our study highlight the potential therapeutic benefits of using pH-responsive poly (AMPS) based hydrogels for targeted medication delivery to the colon, particularly in the treatment of colorectal cancer and associated gastrointestinal problems. Highlights: AMPS-based hydrogel beads with pH-sensitive swelling behavior developed for controlled colonic drug release. Nimesulide successfully loaded into the hydrogel matrix, demonstrating sustained and site-specific drug release in the colon. Structural, physicochemical, and pharmacokinetic properties were confirmed using FTIR, swelling studies, and in vitro drug release assays. Rabbit model studies confirmed the biocompatibility and safety of the hydrogel beads, with no observed acute toxicity. [ABSTRACT FROM AUTHOR]
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Database: Complementary Index
Description
Abstract:Targeted drug delivery to the colon offers a promising approach to enhance therapeutic efficacy while minimizing systemic side effects. Our goal in this study was to create a pH-responsive, crosslinked hydrogel matrix for colonic drug release under control. Hydrogels based on poly (2-acrylamido-2-methylpropanesulfonic acid) (poly (AMPS)) were created by adjusting the amounts of the crosslinker (N, N'-methylene bisacrylamide, MBA) and monomer (AMPS). The resultant solidified hydrogel was converted into hydrogel beads. Several analytical approaches were used to thoroughly analyse the hydrogel beads' structural, physicochemical, and pharmacokinetic characteristics. The existence of the intended chemical connections was confirmed by Fourier Transform Infrared Spectroscopy, and swelling investigations showed that swelling behavior was pH-dependent, with higher pH values causing more swelling. The investigation of drug entrapment efficiency revealed that nimesulide, a model drug, was effectively loaded into the hydrogel matrix. Studies on in vitro drug release showed pH-responsive and prolonged release characteristics, suggesting the possibility of specific delivery of drugs to the colon. Furthermore, the hydrogel beads' capacity to expand and their biocompatibility were confirmed by in vivo testing in rabbit models, where no acute toxicity was noted. The results of our study highlight the potential therapeutic benefits of using pH-responsive poly (AMPS) based hydrogels for targeted medication delivery to the colon, particularly in the treatment of colorectal cancer and associated gastrointestinal problems. Highlights: AMPS-based hydrogel beads with pH-sensitive swelling behavior developed for controlled colonic drug release. Nimesulide successfully loaded into the hydrogel matrix, demonstrating sustained and site-specific drug release in the colon. Structural, physicochemical, and pharmacokinetic properties were confirmed using FTIR, swelling studies, and in vitro drug release assays. Rabbit model studies confirmed the biocompatibility and safety of the hydrogel beads, with no observed acute toxicity. [ABSTRACT FROM AUTHOR]
ISSN:09280707
DOI:10.1007/s10971-025-06855-w