In preprints: unfolding the spatial genomics frontier of mouse gastrulation.

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Bibliographic Details
Title: In preprints: unfolding the spatial genomics frontier of mouse gastrulation.
Authors: Nowotschin, Sonja, Hadjantonakis, Anna-Katerina
Source: Development (09501991); Apr2025, Vol. 152 Issue 8, p1-3, 3p
Subject Terms: HISTORY of biology, DEVELOPMENTAL biology, GENE regulatory networks, TRANSCRIPTION factors, EMBRYONIC stem cells, GASTRULATION
Abstract: The article discusses two preprinted studies that delve into the spatial genomics frontier of mouse gastrulation. Researchers utilized spatial transcriptomics methods to analyze the development of mouse embryos over a 48-hour period, starting at embryonic day 6.5. The studies provide insights into the events of mouse gastrulation and early organogenesis, shedding light on the cellular composition and arrangement during this critical developmental stage. The integration of multi-omic data and computational methods allows for a detailed exploration of gene expression dynamics, cell lineage allocation, and regulatory networks at single-cell resolution in a tissue context. [Extracted from the article]
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Database: Complementary Index
Description
Abstract:The article discusses two preprinted studies that delve into the spatial genomics frontier of mouse gastrulation. Researchers utilized spatial transcriptomics methods to analyze the development of mouse embryos over a 48-hour period, starting at embryonic day 6.5. The studies provide insights into the events of mouse gastrulation and early organogenesis, shedding light on the cellular composition and arrangement during this critical developmental stage. The integration of multi-omic data and computational methods allows for a detailed exploration of gene expression dynamics, cell lineage allocation, and regulatory networks at single-cell resolution in a tissue context. [Extracted from the article]
ISSN:09501991
DOI:10.1242/dev.204822