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Effects and Efficiency of HIFU on Treatment of Cancer and Biological Abnormalities.

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Název: Effects and Efficiency of HIFU on Treatment of Cancer and Biological Abnormalities.
Autoři: Farzanegan, Zahra, Tahmasbi, Marziyeh
Zdroj: Frontiers in Biomedical Technologies; 2025 Supplement, Vol. 12, p1-1, 1p
Témata: TUMOR growth, VIRUS diseases, BLOOD-brain barrier, TISSUES, BLOOD flow
Abstrakt: Background: Considering the importance of minimal side effects and maximum efficiency of a treatment procedure, HIFU (High Intensity Focused Ultrasound) has been used as a relatively new and minimally invasive method for many tumors and abnormalities. The present study was conducted to investigate the effects of HIFU on tumor and the treatment efficiency of abnormalities in biological tissues in preclinical studies. Materials and Methods: The databases of PubMed, science direct, Web of Science and Google scholar were explored. Using the following key words: High Intensity Focused Ultrasound (HIFU), HIFU AND cancer, HIFU AND cancer treatment, HIFU AND Rat, HIFU AND mice, HIFU AND Rabbit. The obtained results were screened for the Title and abstract by two authors and the relevant papers were reviewed for further details. Results: 14 studies were investigated in this research. 7 of the reviewed studies (50%) were related to Rat, 3 cases (21.43%) were related to Rabbit and 4 cases (28.57%) were related to mice. Most of the investigated tumors included liver, brain and colon. Some of them studied the effect of HIFU on viral diseases and the reaction of the immune system to these diseases following the use of HIFU. The effects of HIFU on the tumor included coagulation necrosis in the tumor and necrosis due to decreased blood flow. Moreover, related studies observed effects such as reducing tumor growth, volume and size, apoptosis induction, and further tumor suppression, when used HIFU concurrently with chemotherapy or surgery. Furthermore, HIFU can reduce the Intravascular Growth Factor (IGF) in certain types of tumors. Longevity has also reported for most HIFU-treated study samples. Improving the transfer and distribution of chemotherapy medicines in all parts of the tumor, destroying the blood-brain barrier of the tumor, inducing sensitivity in the immune system and improving the effectiveness of the tumor ablation compared to other treatment procedures, reducing the duration and increasing the peak tumor uptake rate of radiolabeled monoclonal antibodies have also stated in reviewed studies. By affecting the immune system, HIFU helps to improve the efficiency and prolong the effect of vaccines used for viral diseases. Thrombotic effects and destruction of the arterial membrane have also been reported. It should be noted that all the mentioned effects depended on HIFU intensity and tissue characteristics. So that the best results were obtained when the frequency was 2.5 MHz and the exposure was 4300 W/cm². Conclusion: In general, the results of the reviewed studies indicated that HIFU has a direct effect on reducing tumor growth and volume and improves the effect of other methods of tumor inhibition such as chemotherapy and surgery. Also, improves the efficiency of the immune system. Future studies are required for another kinds of cancers and abnormalities for widening information about HIFU efficiency. [ABSTRACT FROM AUTHOR]
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Databáze: Complementary Index
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Abstrakt:Background: Considering the importance of minimal side effects and maximum efficiency of a treatment procedure, HIFU (High Intensity Focused Ultrasound) has been used as a relatively new and minimally invasive method for many tumors and abnormalities. The present study was conducted to investigate the effects of HIFU on tumor and the treatment efficiency of abnormalities in biological tissues in preclinical studies. Materials and Methods: The databases of PubMed, science direct, Web of Science and Google scholar were explored. Using the following key words: High Intensity Focused Ultrasound (HIFU), HIFU AND cancer, HIFU AND cancer treatment, HIFU AND Rat, HIFU AND mice, HIFU AND Rabbit. The obtained results were screened for the Title and abstract by two authors and the relevant papers were reviewed for further details. Results: 14 studies were investigated in this research. 7 of the reviewed studies (50%) were related to Rat, 3 cases (21.43%) were related to Rabbit and 4 cases (28.57%) were related to mice. Most of the investigated tumors included liver, brain and colon. Some of them studied the effect of HIFU on viral diseases and the reaction of the immune system to these diseases following the use of HIFU. The effects of HIFU on the tumor included coagulation necrosis in the tumor and necrosis due to decreased blood flow. Moreover, related studies observed effects such as reducing tumor growth, volume and size, apoptosis induction, and further tumor suppression, when used HIFU concurrently with chemotherapy or surgery. Furthermore, HIFU can reduce the Intravascular Growth Factor (IGF) in certain types of tumors. Longevity has also reported for most HIFU-treated study samples. Improving the transfer and distribution of chemotherapy medicines in all parts of the tumor, destroying the blood-brain barrier of the tumor, inducing sensitivity in the immune system and improving the effectiveness of the tumor ablation compared to other treatment procedures, reducing the duration and increasing the peak tumor uptake rate of radiolabeled monoclonal antibodies have also stated in reviewed studies. By affecting the immune system, HIFU helps to improve the efficiency and prolong the effect of vaccines used for viral diseases. Thrombotic effects and destruction of the arterial membrane have also been reported. It should be noted that all the mentioned effects depended on HIFU intensity and tissue characteristics. So that the best results were obtained when the frequency was 2.5 MHz and the exposure was 4300 W/cm². Conclusion: In general, the results of the reviewed studies indicated that HIFU has a direct effect on reducing tumor growth and volume and improves the effect of other methods of tumor inhibition such as chemotherapy and surgery. Also, improves the efficiency of the immune system. Future studies are required for another kinds of cancers and abnormalities for widening information about HIFU efficiency. [ABSTRACT FROM AUTHOR]
ISSN:23455829