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COVID-19 related risk factors and their association with non-syndromic orofacial clefts in five Arab countries: a case-control study.

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Titel: COVID-19 related risk factors and their association with non-syndromic orofacial clefts in five Arab countries: a case-control study.
Autoren: Sabbagh, Heba Jafar, Alamoudi, Rana A., Zeinalddin, Mohammad, Al Bulushi, Taimoor, Al-Batayneh, Ola B., AboulHassan, Mamdouh A., Koraitim, Mohamed, Quritum, Maryam, Almuqbali, Buthaina, Alghamdi, Sultan Musaad, Refahee, Shaimaa Mohsen, Alkharafi, Lateefa, Taqi, Fatemah Fahad, Albassam, Bader, Ayed, Mariam, Embaireeg, Alia, Alnahdi, Raqiya, AlSharif, Mona Talal, Abdulhameed, Fatma Dawood, Aljohar, Aziza Johar
Quelle: BMC Oral Health; 4/28/2023, Vol. 23 Issue 1, p1-10, 10p
Schlagwörter: FAMILIES & psychology, FRIENDSHIP, MATERNAL exposure, COVID-19, ORAL health, ARABS, PSYCHOLOGY of mothers, FIRST trimester of pregnancy, MISCARRIAGE, CLEFT palate, CASE-control method, FEAR, CLEFT lip, RISK assessment, SOCIAL classes, PUBLIC hospitals, DESCRIPTIVE statistics, METROPOLITAN areas, PRENATAL care, PSYCHOLOGICAL stress
Abstract: Background: The environmental etiology of non-syndromic orofacial clefts (NSOFCs) is still under research. The aim of this case-control study is to assess COVID-19 associated factors that may be related to the risk of NSOFC in five Arab countries. These factors include COVID-19 infection, COVID-19 symptoms, family member or friends infected with COVID-19, stress, smoking, socioeconomic status and fear of COVID-19. Methods: The study took place in governmental hospitals in five Arab countries from November 2020 to November 2021. Controls are matched in the month of delivery and site of recruitment. A clinical examination was carried out using LASHAL classification. Maternal exposure to medication, illnesses, supplementation, COVID-19 infection during their pregestation and 1st trimester periods were evaluated using a validated questionnaire. Maternal exposure to stress was assessed using the Life Events scale, fear of covid-19 scale, family member or friend affected with covid-19 infection, pregnancy planning and threatened abortion. Results: The study recruited 1135 infants (386 NSOFC and 749 controls). Living in urban areas, maternal exposure to medications 3-months pregestation, maternal exposure to any of the prenatal life events and maternal fear of COVID-19 significantly increased the risk of having a child with NSOFC. On the other hand, mothers exposed to supplementation 3-months pregestation, mothers suspected of having COVID-19 infection, family members or friends testing positive with COVID-19 significantly decreased the risk of having a child with NSOFC. Conclusions: This study suggests that NSOFC may be associated with maternal exposure to lifetime stress and COVID-19 fear in particular, with no direct effect of the COVID-19 infection itself. This highlights the importance of providing psychological support for expecting mothers during stressful events that affect populations such as the COVID-19 pandemic, in addition to the usual antenatal care. [ABSTRACT FROM AUTHOR]
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Datenbank: Complementary Index
Beschreibung
Abstract:Background: The environmental etiology of non-syndromic orofacial clefts (NSOFCs) is still under research. The aim of this case-control study is to assess COVID-19 associated factors that may be related to the risk of NSOFC in five Arab countries. These factors include COVID-19 infection, COVID-19 symptoms, family member or friends infected with COVID-19, stress, smoking, socioeconomic status and fear of COVID-19. Methods: The study took place in governmental hospitals in five Arab countries from November 2020 to November 2021. Controls are matched in the month of delivery and site of recruitment. A clinical examination was carried out using LASHAL classification. Maternal exposure to medication, illnesses, supplementation, COVID-19 infection during their pregestation and 1st trimester periods were evaluated using a validated questionnaire. Maternal exposure to stress was assessed using the Life Events scale, fear of covid-19 scale, family member or friend affected with covid-19 infection, pregnancy planning and threatened abortion. Results: The study recruited 1135 infants (386 NSOFC and 749 controls). Living in urban areas, maternal exposure to medications 3-months pregestation, maternal exposure to any of the prenatal life events and maternal fear of COVID-19 significantly increased the risk of having a child with NSOFC. On the other hand, mothers exposed to supplementation 3-months pregestation, mothers suspected of having COVID-19 infection, family members or friends testing positive with COVID-19 significantly decreased the risk of having a child with NSOFC. Conclusions: This study suggests that NSOFC may be associated with maternal exposure to lifetime stress and COVID-19 fear in particular, with no direct effect of the COVID-19 infection itself. This highlights the importance of providing psychological support for expecting mothers during stressful events that affect populations such as the COVID-19 pandemic, in addition to the usual antenatal care. [ABSTRACT FROM AUTHOR]
ISSN:14726831
DOI:10.1186/s12903-023-02934-y