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Impact of the 21-Gene Recurrence Score Assay on Treatment Decisions and Cost in Patients with Node-Positive Breast Cancer: A Multicenter Study in Quebec.

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Názov: Impact of the 21-Gene Recurrence Score Assay on Treatment Decisions and Cost in Patients with Node-Positive Breast Cancer: A Multicenter Study in Quebec.
Autori: Hassan, Saima, Younan, Rami, Patocskai, Erica, Provencher, Louise, Poirier, Brigitte, Sideris, Luca, Dubé, Pierre, Mihalcioiu, Catalin, Chabot-Blanchet, Malorie, Guertin, Marie-Claude, Boileau, Jean-François, Robidoux, André
Zdroj: Oncologist; Oct2022, Vol. 27 Issue 10, p822-831, 10p, 5 Charts, 2 Graphs
Predmety: RESEARCH, SCIENTIFIC observation, CONFIDENCE, PROFESSIONS, CANCER chemotherapy, MEDICAL care costs, LYMPH nodes, ANTINEOPLASTIC agents, CANCER relapse, COST control, CANCER patients, ESTROGEN receptors, PRE-tests & post-tests, GENE expression profiling, QUESTIONNAIRES, DESCRIPTIVE statistics, COST effectiveness, DECISION making in clinical medicine, PHYSICIANS, HORMONE receptor positive breast cancer, LONGITUDINAL method, PROGESTERONE receptors
Geografický termín: QUEBEC (Province)
Abstrakt: Background The 21-gene Breast Recurrence Score (RS) assay, "the assay", has led to a paradigm shift for patients with hormone receptor-positive, node-negative early breast cancer and is emerging as an important tool to assist physician-patient decisions in foregoing chemotherapy in node-positive patients. We wanted to better understand the impact of the RS assay in node-positive patients upon physician treatment decisions and treatment cost in Quebec, Canada. Patients and Methods We conducted a multicenter, prospective observational trial for Estrogen/Progesterone Receptor (ER/PR)- positive, Human Epidermal Growth Factor Receptor 2 (HER2)-negative breast cancer patients with 1-3 positive lymph nodes. Physicians completed a questionnaire indicating treatment choice prior to and post availability of RS results. The primary endpoint was change in the physician's recommendation for chemotherapy prior to and post assay results. Secondary endpoints included change in physician's expressed level of confidence, and changes in estimated cost of recommended treatments prior to and post assay results. Results For the entire cohort, physician recommendation for chemotherapy was reduced by an absolute 67.1% by knowledge of the RS assay result (P <.0001). Physician recommendation of chemotherapy was decreased by 75.9% for patients RS result <14 (P <.0001); and 67.5% for patients with RS result 14-25 (P <.0001). Changes in treatment recommendations were associated with an overall reduction in cost by 73.7% per patient, and after incorporating the cost of the RS test, a cost benefit of $823 CAN at 6-month follow-up. Conclusion Altogether, we established that the assay led to a two-third reduction in the use of chemotherapy, and was a cost-effective approach for hormone receptor-positive, node-positive breast cancer. [ABSTRACT FROM AUTHOR]
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Databáza: Complementary Index
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Abstrakt:Background The 21-gene Breast Recurrence Score (RS) assay, "the assay", has led to a paradigm shift for patients with hormone receptor-positive, node-negative early breast cancer and is emerging as an important tool to assist physician-patient decisions in foregoing chemotherapy in node-positive patients. We wanted to better understand the impact of the RS assay in node-positive patients upon physician treatment decisions and treatment cost in Quebec, Canada. Patients and Methods We conducted a multicenter, prospective observational trial for Estrogen/Progesterone Receptor (ER/PR)- positive, Human Epidermal Growth Factor Receptor 2 (HER2)-negative breast cancer patients with 1-3 positive lymph nodes. Physicians completed a questionnaire indicating treatment choice prior to and post availability of RS results. The primary endpoint was change in the physician's recommendation for chemotherapy prior to and post assay results. Secondary endpoints included change in physician's expressed level of confidence, and changes in estimated cost of recommended treatments prior to and post assay results. Results For the entire cohort, physician recommendation for chemotherapy was reduced by an absolute 67.1% by knowledge of the RS assay result (P <.0001). Physician recommendation of chemotherapy was decreased by 75.9% for patients RS result <14 (P <.0001); and 67.5% for patients with RS result 14-25 (P <.0001). Changes in treatment recommendations were associated with an overall reduction in cost by 73.7% per patient, and after incorporating the cost of the RS test, a cost benefit of $823 CAN at 6-month follow-up. Conclusion Altogether, we established that the assay led to a two-third reduction in the use of chemotherapy, and was a cost-effective approach for hormone receptor-positive, node-positive breast cancer. [ABSTRACT FROM AUTHOR]
ISSN:10837159
DOI:10.1093/oncolo/oyac123