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Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis.

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Název: Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis.
Autoři: Walker, N F, Karim, F, Moosa, M Y S, Moodley, S, Mazibuko, M, Khan, K, Sterling, T R, Heijden, Y F van der, Grant, A D, Elkington, P T, Pym, A, Leslie, A, van der Heijden, Y F
Zdroj: Journal of Infectious Diseases; Sep2022, Vol. 226 Issue 5, p928-932, 5p
Témata: HIV infection complications, TUBERCULOSIS diagnosis, TUBERCULOSIS complications, SPUTUM, PROTEOLYTIC enzymes, MYCOBACTERIUM tuberculosis, RESEARCH funding
Abstrakt: Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decreased during treatment. Plasma MMP-8 was increased in sputum Mycobacterium tuberculosis culture-positive relative to culture-negative participants, before (median, 4993 pg/mL [interquartile range, 2542-9188] vs 698 [218-4060] pg/mL, respectively; P = .004) and after (3650 [1214-3888] vs 720 [551-1321] pg/mL; P = .008) 6 months of tuberculosis treatment. Consequently, plasma MMP-8 is a potential biomarker to enhance tuberculosis treatment monitoring and screen for possible culture positivity. [ABSTRACT FROM AUTHOR]
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Databáze: Complementary Index
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Abstrakt:Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decreased during treatment. Plasma MMP-8 was increased in sputum Mycobacterium tuberculosis culture-positive relative to culture-negative participants, before (median, 4993 pg/mL [interquartile range, 2542-9188] vs 698 [218-4060] pg/mL, respectively; P = .004) and after (3650 [1214-3888] vs 720 [551-1321] pg/mL; P = .008) 6 months of tuberculosis treatment. Consequently, plasma MMP-8 is a potential biomarker to enhance tuberculosis treatment monitoring and screen for possible culture positivity. [ABSTRACT FROM AUTHOR]
ISSN:00221899
DOI:10.1093/infdis/jiac160