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The human FOXM1 homolog promotes basal progenitor cell proliferation and cortical folding in mouse.

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Title: The human FOXM1 homolog promotes basal progenitor cell proliferation and cortical folding in mouse.
Authors: Wang, Wenwen, Su, Libo, Ji, Fen, Zhang, Dongming, Wang, Yanyan, Zhao, Jinyue, Jiao, Ross Dingyan, Zhang, Mengtian, Huang, Enyu, Jiang, Hong, Zhang, Jingjing, Jiao, Jianwei
Source: EMBO Reports; 3/3/2022, Vol. 23 Issue 3, p1-15, 15p
Abstract: Cortical expansion and folding are key processes in human brain development and evolution and are considered to be principal elements of intellectual ability. How cortical folding has evolved and is induced during embryo development is not well understood. Here, we show that the expression of human FOXM1 promotes basal progenitor cell proliferation and induces cortical thickening and folding in mice. Human‐specific protein sequences further promote the generation of basal progenitor cells. Human FOXM1 increases the proliferation of neural progenitors by binding to the Lin28a promoter and increasing Lin28a expression. Furthermore, overexpression of LIN28A rescues the proliferation of human FOXM1 knockout neural progenitor cells. Together, our findings demonstrate that a human gene can increase the number of basal progenitor cells in mice, leading to brain size increase and gyrification, and may thus contribute to evolutionary brain development and cortical expansion. SYNOPSIS: The human gene FOXM1 promotes the proliferation of basal progenitor cells in mice, leading to brain size increase and gyrification. It may thus contribute to the underlying mechanisms of brain development and evolution. FOXM1 expression in mice leads to cortical expansion and folding and promotes basal progenitor proliferation.Human‐specific exon9 contributes to the generation of basal progenitor cells.FOXM1 promotes neurogenesis and cortical expansion by targeting the Lin28a promoter and inducing Lin28a expression.FOXM1 and LIN28A promote human neural precursor cell proliferation. [ABSTRACT FROM AUTHOR]
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Database: Complementary Index
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Abstract:Cortical expansion and folding are key processes in human brain development and evolution and are considered to be principal elements of intellectual ability. How cortical folding has evolved and is induced during embryo development is not well understood. Here, we show that the expression of human FOXM1 promotes basal progenitor cell proliferation and induces cortical thickening and folding in mice. Human‐specific protein sequences further promote the generation of basal progenitor cells. Human FOXM1 increases the proliferation of neural progenitors by binding to the Lin28a promoter and increasing Lin28a expression. Furthermore, overexpression of LIN28A rescues the proliferation of human FOXM1 knockout neural progenitor cells. Together, our findings demonstrate that a human gene can increase the number of basal progenitor cells in mice, leading to brain size increase and gyrification, and may thus contribute to evolutionary brain development and cortical expansion. SYNOPSIS: The human gene FOXM1 promotes the proliferation of basal progenitor cells in mice, leading to brain size increase and gyrification. It may thus contribute to the underlying mechanisms of brain development and evolution. FOXM1 expression in mice leads to cortical expansion and folding and promotes basal progenitor proliferation.Human‐specific exon9 contributes to the generation of basal progenitor cells.FOXM1 promotes neurogenesis and cortical expansion by targeting the Lin28a promoter and inducing Lin28a expression.FOXM1 and LIN28A promote human neural precursor cell proliferation. [ABSTRACT FROM AUTHOR]
ISSN:1469221X
DOI:10.15252/embr.202153602