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An intraoperative study with ex vivo fluorescence confocal microscopy: diagnostic accuracy of the three visualization modalities.

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Title: An intraoperative study with ex vivo fluorescence confocal microscopy: diagnostic accuracy of the three visualization modalities.
Authors: Reggiani, C., Pellacani, G., Reggiani Bonetti, L., Zanelli, G., Azzoni, P., Chester, J., Kaleci, S., Ferrari, B., Bellini, P., Longo, C., Bertoni, L., Magnoni, C.
Source: Journal of the European Academy of Dermatology & Venereology; Jan2021, Vol. 35 Issue 1, pe92-e94, 3p
Subject Terms: FLUORESCENCE microscopy, VISUALIZATION, MOHS surgery, BASAL cell carcinoma
Abstract: I Ex vivo i fluorescence confocal microscopy (FCM) is an imaging technique that captures real-time digital images of freshly excised tissue with quasi-histopathological resolution. FCM reduces time to image acquisition compared to haematoxylin and eosin (H&E) frozen section analysis.1-3 FCM has been assessed for its application in intraoperative diagnosis of skin tumours, such as rare malignant adnexal, conjunctival and melanocytic tumours, and inflammatory skin diseases.4-7 A recent study estimated an 80% sensitivity and 96% specificity compared to H&E frozen sections for microscopically guided surgery with a previous generation FCM instrument3. The pathologists also achieved >=90% correct diagnoses with BW and H&E-like modalities, but interestingly only concluded 84% correct diagnoses with GW mode images. [Extracted from the article]
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Database: Complementary Index
Description
Abstract:I Ex vivo i fluorescence confocal microscopy (FCM) is an imaging technique that captures real-time digital images of freshly excised tissue with quasi-histopathological resolution. FCM reduces time to image acquisition compared to haematoxylin and eosin (H&E) frozen section analysis.1-3 FCM has been assessed for its application in intraoperative diagnosis of skin tumours, such as rare malignant adnexal, conjunctival and melanocytic tumours, and inflammatory skin diseases.4-7 A recent study estimated an 80% sensitivity and 96% specificity compared to H&E frozen sections for microscopically guided surgery with a previous generation FCM instrument3. The pathologists also achieved >=90% correct diagnoses with BW and H&E-like modalities, but interestingly only concluded 84% correct diagnoses with GW mode images. [Extracted from the article]
ISSN:09269959
DOI:10.1111/jdv.16831