Ambient PM 2.5 and O 3 and their combined effects on the onset of acute cardiovascular events: a time-stratified case-crossover study in Jining, China (2015-2023).
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| Názov: | Ambient PM |
|---|---|
| Autori: | Song SH; Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, 44# Wenhuaxi Road, Lixia District, Jinan, Shandong, 250012, China., Tong M; National Centre for Epidemiology and Population Health, The Australian National University, Canberra, ACT, 2601, Australia., Wang M; Jining Center for Disease Control and Prevention, Jining, Shandong, China., Li SF; Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, 44# Wenhuaxi Road, Lixia District, Jinan, Shandong, 250012, China., Cheng CL; Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, 44# Wenhuaxi Road, Lixia District, Jinan, Shandong, 250012, China., Xi R; Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, 44# Wenhuaxi Road, Lixia District, Jinan, Shandong, 250012, China., Gao Q; Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, 44# Wenhuaxi Road, Lixia District, Jinan, Shandong, 250012, China., Li R; Jining Center for Disease Control and Prevention, Jining, Shandong, China., Liang YM; Jining Center for Disease Control and Prevention, Jining, Shandong, China., Li XJ; Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, 44# Wenhuaxi Road, Lixia District, Jinan, Shandong, 250012, China. xjli@sdu.edu.cn. |
| Zdroj: | BMC public health [BMC Public Health] 2025 Dec 05; Vol. 25 (1), pp. 4224. Date of Electronic Publication: 2025 Dec 05. |
| Spôsob vydávania: | Journal Article |
| Jazyk: | English |
| Informácie o časopise: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968562 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2458 (Electronic) Linking ISSN: 14712458 NLM ISO Abbreviation: BMC Public Health Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2001- |
| Výrazy zo slovníka MeSH: | Particulate Matter*/adverse effects , Particulate Matter*/analysis , Cardiovascular Diseases*/epidemiology , Ozone*/adverse effects , Ozone*/analysis , Air Pollutants*/analysis , Air Pollutants*/adverse effects , Environmental Exposure*/adverse effects, Humans ; China/epidemiology ; Male ; Female ; Cross-Over Studies ; Middle Aged ; Aged ; Adult |
| Abstrakt: | Background: The existing literature on the associations between short-term exposure to PM Methods: A time-stratified case-crossover study was implemented to examine 424,069 cases of ACE in Jining City, China, between 2015 and 2023. This study used each case as its own control. PM Results: Exposure to PM Conclusions: PM (© 2025. The Author(s).) |
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| Grant Information: | 2023YFC2604400, 2023YFC2604401 National Key Research and Development Program of China |
| Contributed Indexing: | Keywords: Acute cardiovascular events; Interaction; Ozone; Particulate matter |
| Substance Nomenclature: | 0 (Particulate Matter) 66H7ZZK23N (Ozone) 0 (Air Pollutants) |
| Entry Date(s): | Date Created: 20251205 Date Completed: 20251205 Latest Revision: 20251205 |
| Update Code: | 20251206 |
| DOI: | 10.1186/s12889-025-25166-x |
| PMID: | 41350666 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Background: The existing literature on the associations between short-term exposure to PM <subscript>2.5</subscript> and O <subscript>3</subscript> and acute cardiovascular events (ACE) has yielded inconclusive findings, and little is known about the potential interactions of PM <subscript>2.5</subscript> and O <subscript>3</subscript> . This study aims to analyze the impacts of PM <subscript>2.5</subscript> and O <subscript>3</subscript> on ACE onset and their potential interactions.<br />Methods: A time-stratified case-crossover study was implemented to examine 424,069 cases of ACE in Jining City, China, between 2015 and 2023. This study used each case as its own control. PM <subscript>2.5</subscript> and O <subscript>3</subscript> concentrations were allocated to each case and control day based on the home address of each individual. Quantitative effects of short-term exposure to PM <subscript>2.5</subscript> and O <subscript>3</subscript> on the onset of ACE and its subtypes, including acute myocardial infarction (AMI), stroke, and sudden cardiac death (SCD), were assessed using conditional logistic regression models. Subgroup analyses were performed to investigate the effect modification by gender, age, and season. Stratified analyses by co-pollutant exposures and synergy index (SI) were applied to test the interaction of PM <subscript>2.5</subscript> and O <subscript>3</subscript> .<br />Results: Exposure to PM <subscript>2.5</subscript> and O <subscript>3</subscript> was associated with an increased risk of ACE onset, particularly on the day of onset and the day before. Specifically, for each interquartile range (IQR) increase of 45.10 µg/m³in PM <subscript>2.5</subscript> at lag0-1 and 72.70 µg/m³in O <subscript>3</subscript> at lag0-1, the ORs were 1.023 (95% CI: 1.018-1.029) and 1.032 (95% CI: 1.020-1.044) for ACE. Similar results were observed for AMI and stroke, but not for SCD. PM <subscript>2.5</subscript> had more pronounced detrimental effects on older adults (age ≥ 65), males, and during cold seasons, while O <subscript>3</subscript> had more pronounced detrimental effects on older adults (age ≥ 65) and during warm seasons, with no significant gender difference for O <subscript>3</subscript> . No significant interaction between PM <subscript>2.5</subscript> and O <subscript>3</subscript> on ACE onset was found (SI [95% CI]: 1.50 [0.36-6.29]), though PM <subscript>2.5</subscript> or O <subscript>3</subscript> had more pronounced detrimental effects at lower concentrations of the other pollutants.<br />Conclusions: PM <subscript>2.5</subscript> and O <subscript>3</subscript> are risk factors for ACE onset, particularly on the day of onset and the day before. Moreover, we found no significant interaction of PM <subscript>2.5</subscript> and O <subscript>3</subscript> on ACE onset. Reducing PM <subscript>2.5</subscript> and O <subscript>3</subscript> concentrations and avoiding exposure to high levels of these pollutants in the early phase may mitigate ACE onset. Targeted policies aimed at reducing PM <subscript>2.5</subscript> and O <subscript>3</subscript> pollution should be developed to mitigate their adverse health effects among high-risk populations, including older adults and males.<br /> (© 2025. The Author(s).) |
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| ISSN: | 1471-2458 |
| DOI: | 10.1186/s12889-025-25166-x |