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Relationship Between the Systemic Immune-Inflammation Index and Non-Dipper Blood Pressure Status in Normotensive Patients With Prediabetes.

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Název: Relationship Between the Systemic Immune-Inflammation Index and Non-Dipper Blood Pressure Status in Normotensive Patients With Prediabetes.
Autoři: Turan E; Department of Endocrinology, Faculty of Medicine, Samsun University, Samsun, Turkey., Turan Y; Department of Cardiology, Faculty of Medicine, Samsun University, Samsun, Turkey., Yolcu M; Department of Cardiology, Faculty of Medicine, İstanbul Yeni Yüzyıl University, İstanbul, Turkey., Kızılkaya H; Department of Internal Medicine, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey., Sivri S; Department of Cardiology, Samsun Education and Research Hospital, Samsun, Turkey., Karagöz A; Department of Cardiology, Faculty of Medicine, Samsun University, Samsun, Turkey.
Zdroj: Journal of clinical hypertension (Greenwich, Conn.) [J Clin Hypertens (Greenwich)] 2025 Dec; Vol. 27 (12), pp. e70189.
Způsob vydávání: Journal Article
Jazyk: English
Informace o časopise: Publisher: Wiley Periodicals Inc Country of Publication: United States NLM ID: 100888554 Publication Model: Print Cited Medium: Internet ISSN: 1751-7176 (Electronic) Linking ISSN: 15246175 NLM ISO Abbreviation: J Clin Hypertens (Greenwich) Subsets: MEDLINE
Imprint Name(s): Publication: : [Hoboken, NJ] : Wiley Periodicals Inc.
Original Publication: Greenwich, CT : Le Jacq Communication, Inc., c1999-
Výrazy ze slovníku MeSH: Prediabetic State*/physiopathology , Prediabetic State*/immunology , Prediabetic State*/blood , Blood Pressure*/physiology , Inflammation*/immunology , Inflammation*/blood , Inflammation*/physiopathology , Hypertension*/physiopathology, Humans ; Male ; Female ; Cross-Sectional Studies ; Middle Aged ; C-Reactive Protein/analysis ; C-Reactive Protein/metabolism ; Adult ; Cardiovascular Diseases ; Blood Pressure Determination/methods
Abstrakt: Prediabetes is the period in which serum glucose levels begin to rise but do not yet meet the criteria for diabetes. Non-dipper blood pressure (BP) is related to a significant increase in cardiovascular disease (CVD) and organ damage compared to those with dipper BP in hypertensive individuals. Inflammation plays a role in the development of atherosclerosis and CVD. The data on whether nighttime status is important in normotensive individuals are limited. We aimed to investigate the relationship between dipper and non-dipper BP status and inflammatory parameters in normotensive patients with prediabetes. The study had a cross-sectional design. Of the 208 prediabetic and normotensive individuals included in the study, 90 were in the dipper BP group, and 118 were in the non-dipper BP group. In all subjects, the collection of venous peripheral blood samples was performed on admission. The two groups exhibited similar clinical baseline characteristics. C-reactive protein (CRP) and systemic immune-inflammation index (SII) were significantly higher in the non-dipper BP group (CRP: 7.19 ± 4.01 vs. 6.20 ± 4.32 mg/L, p = 0.043; SII: 782.79 vs. 613.43, p = 0.014). In the logistic regression analysis, SII was independently associated with non-dipper BP status [OR = 1.001, CI (1.000-1.001), p = 0.017]. In prediabetic patients, non-dipper BP status may be associated with inflammation and, consequently, increased CVD risk, even in normotensive individuals. Identifying factors that increase the risk in prediabetic patients may be important in terms of improving their future cardiovascular health.
(© 2025 The Author(s). The Journal of Clinical Hypertension published by Wiley Periodicals LLC.)
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Contributed Indexing: Keywords: inflammation; normotensive non‐dipper status; prediabetes
Substance Nomenclature: 9007-41-4 (C-Reactive Protein)
Entry Date(s): Date Created: 20251130 Date Completed: 20251130 Latest Revision: 20251203
Update Code: 20251203
PubMed Central ID: PMC12665134
DOI: 10.1111/jch.70189
PMID: 41319114
Databáze: MEDLINE
Popis
Abstrakt:Prediabetes is the period in which serum glucose levels begin to rise but do not yet meet the criteria for diabetes. Non-dipper blood pressure (BP) is related to a significant increase in cardiovascular disease (CVD) and organ damage compared to those with dipper BP in hypertensive individuals. Inflammation plays a role in the development of atherosclerosis and CVD. The data on whether nighttime status is important in normotensive individuals are limited. We aimed to investigate the relationship between dipper and non-dipper BP status and inflammatory parameters in normotensive patients with prediabetes. The study had a cross-sectional design. Of the 208 prediabetic and normotensive individuals included in the study, 90 were in the dipper BP group, and 118 were in the non-dipper BP group. In all subjects, the collection of venous peripheral blood samples was performed on admission. The two groups exhibited similar clinical baseline characteristics. C-reactive protein (CRP) and systemic immune-inflammation index (SII) were significantly higher in the non-dipper BP group (CRP: 7.19 ± 4.01 vs. 6.20 ± 4.32 mg/L, p = 0.043; SII: 782.79 vs. 613.43, p = 0.014). In the logistic regression analysis, SII was independently associated with non-dipper BP status [OR = 1.001, CI (1.000-1.001), p = 0.017]. In prediabetic patients, non-dipper BP status may be associated with inflammation and, consequently, increased CVD risk, even in normotensive individuals. Identifying factors that increase the risk in prediabetic patients may be important in terms of improving their future cardiovascular health.<br /> (© 2025 The Author(s). The Journal of Clinical Hypertension published by Wiley Periodicals LLC.)
ISSN:1751-7176
DOI:10.1111/jch.70189