Thoracolumbar disc herniation in Scheuermann's disease: distinct clinical characteristics in elderly and adolescent patients.
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| Titel: | Thoracolumbar disc herniation in Scheuermann's disease: distinct clinical characteristics in elderly and adolescent patients. |
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| Autoren: | Xu Z; Department of Orthopedics, Peking University Third Hospital, No 49. North Garden Street, Hai Dian District, Beijing, 100191, China.; Beijing Key Laboratory of Spinal Disease Research, Peking University Third Hospital, 49 North Garden Road, Beijing, 100191, China., Zhou S; Department of Orthopedics, Peking University Third Hospital, No 49. North Garden Street, Hai Dian District, Beijing, 100191, China.; Beijing Key Laboratory of Spinal Disease Research, Peking University Third Hospital, 49 North Garden Road, Beijing, 100191, China., Hu Y; Department of Orthopedics, Peking University Third Hospital, No 49. North Garden Street, Hai Dian District, Beijing, 100191, China.; Beijing Key Laboratory of Spinal Disease Research, Peking University Third Hospital, 49 North Garden Road, Beijing, 100191, China., Yuan L; Department of Orthopedics, Peking University Third Hospital, No 49. North Garden Street, Hai Dian District, Beijing, 100191, China.; Beijing Key Laboratory of Spinal Disease Research, Peking University Third Hospital, 49 North Garden Road, Beijing, 100191, China., Chen G; Department of Orthopedics, Peking University Third Hospital, No 49. North Garden Street, Hai Dian District, Beijing, 100191, China.; Beijing Key Laboratory of Spinal Disease Research, Peking University Third Hospital, 49 North Garden Road, Beijing, 100191, China., Jiang S; Department of Orthopedics, Peking University Third Hospital, No 49. North Garden Street, Hai Dian District, Beijing, 100191, China.; Beijing Key Laboratory of Spinal Disease Research, Peking University Third Hospital, 49 North Garden Road, Beijing, 100191, China., Guo X; Department of Orthopedics, Peking University Third Hospital, No 49. North Garden Street, Hai Dian District, Beijing, 100191, China.; Beijing Key Laboratory of Spinal Disease Research, Peking University Third Hospital, 49 North Garden Road, Beijing, 100191, China., Zhong W; Department of Orthopedics, Peking University Third Hospital, No 49. North Garden Street, Hai Dian District, Beijing, 100191, China.; Beijing Key Laboratory of Spinal Disease Research, Peking University Third Hospital, 49 North Garden Road, Beijing, 100191, China., Li W; Department of Orthopedics, Peking University Third Hospital, No 49. North Garden Street, Hai Dian District, Beijing, 100191, China.; Beijing Key Laboratory of Spinal Disease Research, Peking University Third Hospital, 49 North Garden Road, Beijing, 100191, China., Zhou F; Department of Orthopedics, Peking University Third Hospital, No 49. North Garden Street, Hai Dian District, Beijing, 100191, China. zhoufeifei@pku.edu.cn.; Beijing Key Laboratory of Spinal Disease Research, Peking University Third Hospital, 49 North Garden Road, Beijing, 100191, China. zhoufeifei@pku.edu.cn., Sun C; Department of Orthopedics, Peking University Third Hospital, No 49. North Garden Street, Hai Dian District, Beijing, 100191, China. sunchuiguo@163.com.; Beijing Key Laboratory of Spinal Disease Research, Peking University Third Hospital, 49 North Garden Road, Beijing, 100191, China. sunchuiguo@163.com. |
| Quelle: | BMC musculoskeletal disorders [BMC Musculoskelet Disord] 2025 Nov 24; Vol. 26 (1), pp. 1068. Date of Electronic Publication: 2025 Nov 24. |
| Publikationsart: | Journal Article |
| Sprache: | English |
| Info zur Zeitschrift: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968565 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2474 (Electronic) Linking ISSN: 14712474 NLM ISO Abbreviation: BMC Musculoskelet Disord Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2000- |
| MeSH-Schlagworte: | Intervertebral Disc Displacement*/surgery , Intervertebral Disc Displacement*/etiology , Intervertebral Disc Displacement*/diagnostic imaging , Intervertebral Disc Displacement*/epidemiology , Thoracic Vertebrae*/diagnostic imaging , Thoracic Vertebrae*/surgery , Thoracic Vertebrae*/pathology , Lumbar Vertebrae*/diagnostic imaging , Lumbar Vertebrae*/surgery , Lumbar Vertebrae*/pathology , Scheuermann Disease*/complications , Scheuermann Disease*/diagnostic imaging , Scheuermann Disease*/epidemiology , Scheuermann Disease*/surgery, Humans ; Male ; Female ; Retrospective Studies ; Aged ; Adolescent ; Middle Aged ; Young Adult ; Adult ; Age Factors ; Ligamentum Flavum/pathology ; Intervertebral Disc Degeneration |
| Abstract: | Competing Interests: Declarations. Ethics approval and consent to participate: The Ethical Committee of Peking University Third Hospital approved this research (IRB00006761-M2023267). The need of consent from participate was waived with exemption from informed consent because this research is a retrospective study. This research is in compliance with the Helsinki Declaration. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Background: Scheuermann's disease always occurs in adolescent, and it is uncommon for elderly individuals. The aim of this research is to investigate the different potential pathogenic mechanisms and clinical characteristics of thoracolumbar disc herniation (TLDH) in Scheuermann's disease between elderly and adolescent patients. Methods: We retrospectively analyzed data from patients with Scheuermann's disease who underwent surgical treatment for TLDH from a single center between June 2013 and June 2023. Patients were divided into two groups: elderly (≥ 65 years) and adolescent (≤ 20 years), with 24 patients in each group. Data, including medical records and imaging parameters, were independently collected and analyzed by two doctors. Results: The elderly group exhibited significantly lower preoperative modified Japanese Orthopaedic Association (mJOA) scores (5.58 ± 2.38 vs. 7.25 ± 2.19, P = 0.009) and longer symptom duration (48.29 ± 62.32 vs. 8.37 ± 13.19 months, P < 0.001) compared to the adolescent group. The elderly group also had a higher prevalence of diabetes mellitus (6/24 vs. 0/24, P = 0.029), fewer Schmorl's nodes, more severe intervertebral disc degeneration, and a higher frequency of intervertebral disc vacuum phenomena. Additionally, elderly patients exhibited more frequent localized ossification or hypertrophy of the ligamentum flavum in the thoracolumbar region. Conclusion: The later onset of TLDH in Scheuermann's disease among elderly patients is likely due to a combination of genetically determined higher endplate strength and age-related degenerative factors. Elderly patients also commonly show localized ossification or hypertrophy of the ligamentum flavum, which may contribute to more severe symptoms. (© 2025. The Author(s).) |
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| Grant Information: | Y77477-03 Peking University Third Hospital Talent Incubation Fund; BYSYDL2022009 The Peking University Third Hospital Clinical Cohort Project; 7252164 Natural Science Foundation of Beijing Municipality |
| Contributed Indexing: | Keywords: Elderly; Pathogenesis; Scheuermann’s disease; Thoracolumbar disc herniation |
| Entry Date(s): | Date Created: 20251125 Date Completed: 20251125 Latest Revision: 20251128 |
| Update Code: | 20251128 |
| PubMed Central ID: | PMC12642369 |
| DOI: | 10.1186/s12891-025-09292-6 |
| PMID: | 41286794 |
| Datenbank: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstract: | Competing Interests: Declarations. Ethics approval and consent to participate: The Ethical Committee of Peking University Third Hospital approved this research (IRB00006761-M2023267). The need of consent from participate was waived with exemption from informed consent because this research is a retrospective study. This research is in compliance with the Helsinki Declaration. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.<br />Background: Scheuermann's disease always occurs in adolescent, and it is uncommon for elderly individuals. The aim of this research is to investigate the different potential pathogenic mechanisms and clinical characteristics of thoracolumbar disc herniation (TLDH) in Scheuermann's disease between elderly and adolescent patients.<br />Methods: We retrospectively analyzed data from patients with Scheuermann's disease who underwent surgical treatment for TLDH from a single center between June 2013 and June 2023. Patients were divided into two groups: elderly (≥ 65 years) and adolescent (≤ 20 years), with 24 patients in each group. Data, including medical records and imaging parameters, were independently collected and analyzed by two doctors.<br />Results: The elderly group exhibited significantly lower preoperative modified Japanese Orthopaedic Association (mJOA) scores (5.58 ± 2.38 vs. 7.25 ± 2.19, P = 0.009) and longer symptom duration (48.29 ± 62.32 vs. 8.37 ± 13.19 months, P < 0.001) compared to the adolescent group. The elderly group also had a higher prevalence of diabetes mellitus (6/24 vs. 0/24, P = 0.029), fewer Schmorl's nodes, more severe intervertebral disc degeneration, and a higher frequency of intervertebral disc vacuum phenomena. Additionally, elderly patients exhibited more frequent localized ossification or hypertrophy of the ligamentum flavum in the thoracolumbar region.<br />Conclusion: The later onset of TLDH in Scheuermann's disease among elderly patients is likely due to a combination of genetically determined higher endplate strength and age-related degenerative factors. Elderly patients also commonly show localized ossification or hypertrophy of the ligamentum flavum, which may contribute to more severe symptoms.<br /> (© 2025. The Author(s).) |
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| ISSN: | 1471-2474 |
| DOI: | 10.1186/s12891-025-09292-6 |