Heterogeneous impact of fine particulate matter constituents on pulmonary tuberculosis onset: a multicenter time series study in Beijing.
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| Název: | Heterogeneous impact of fine particulate matter constituents on pulmonary tuberculosis onset: a multicenter time series study in Beijing. |
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| Autoři: | Li S; Department of Infectious Disease, Beijing Friendship Hospital, Capital Medical University, No.95 Yong 'an Road, Xicheng District, Beijing, 100050, China., Guo F; The second clinical medical college, Capital Medical University, Beijing, China., Wang C; Department of Infectious Disease, Beijing Friendship Hospital, Capital Medical University, No.95 Yong 'an Road, Xicheng District, Beijing, 100050, China., Liu R; Department of Research Ward, Beijing Chest Hospital, Capital Medical University, No. 97 Ma Chang, Tongzhou District, Beijing, 101149, China. Lrongmei@163.com., Qi W; Department of Infectious Disease, Beijing Friendship Hospital, Capital Medical University, No.95 Yong 'an Road, Xicheng District, Beijing, 100050, China. qi_wenjie@ccmu.edu.cn. |
| Zdroj: | BMC public health [BMC Public Health] 2025 Nov 24; Vol. 25 (1), pp. 4103. Date of Electronic Publication: 2025 Nov 24. |
| Způsob vydávání: | Journal Article; Multicenter Study |
| Jazyk: | English |
| Informace o časopise: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968562 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2458 (Electronic) Linking ISSN: 14712458 NLM ISO Abbreviation: BMC Public Health Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2001- |
| Výrazy ze slovníku MeSH: | Tuberculosis, Pulmonary*/epidemiology , Tuberculosis, Pulmonary*/etiology , Particulate Matter*/adverse effects , Particulate Matter*/analysis , Air Pollutants*/analysis , Air Pollutants*/adverse effects , Environmental Exposure*/adverse effects , Environmental Exposure*/analysis, Humans ; Beijing/epidemiology ; Male |
| Abstrakt: | Competing Interests: Declarations. Ethics approval and consent to participate: This study was approved by the Bioethics Committee of Beijing Friendship Hospital, Capital Medical University (Approval Reference: 2025-P2-170-01). All research was performed in accordance with the Declaration of Helsinki. As this study was a retrospective analysis based on anonymized surveillance data, the need for informed consent was waived by the ethics committee. Consent for publication: This manuscript does not contain any individual person’s data in any form. Therefore, consent for publication is not applicable. Competing interests: The authors declare no competing interests. Background: Epidemiological studies have implicated exposure to PM₂.₅ in the development of pulmonary tuberculosis (PTB); however, the key constituents driving this effect have not been clearly identified. Methods: A time-series analysis spanning 2019 to 2023 was performed across several centers in Beijing to assess the links between major PM Results: All five examined components demonstrated significant relationships with an elevated risk of PTB. Associations were not statistically significant on the same day (lag 0) or the next day (lag 1) after exposure. A clear risk increase was detected starting at a 2-day lag, which was no longer observable by lag 3. Per interquartile range (IQR) rise in the 3-day moving average (lag 0-2) of black carbon and organic matter, the relative risks (RRs) for PTB were 1.11 [95% confidence interval (CI): 1.03, 1.19] and 1.11 (95% CI: 1.03, 1.21), correspondingly. Together, these two components were the dominant drivers of the overall PM₂.₅ effect, contributing 41% and 39% of the joint risk, respectively. Conclusions: The results yield novel evidence that exposure to certain PM (© 2025. The Author(s).) |
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| Contributed Indexing: | Keywords: Fine particulate matter constituents; Fine particulate matter constituents variation; Multicenter study; Pulmonary tuberculosis; Time-series study |
| Substance Nomenclature: | 0 (Particulate Matter) 0 (Air Pollutants) |
| Entry Date(s): | Date Created: 20251125 Date Completed: 20251125 Latest Revision: 20251128 |
| Update Code: | 20251128 |
| PubMed Central ID: | PMC12642183 |
| DOI: | 10.1186/s12889-025-25116-7 |
| PMID: | 41286687 |
| Databáze: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Competing Interests: Declarations. Ethics approval and consent to participate: This study was approved by the Bioethics Committee of Beijing Friendship Hospital, Capital Medical University (Approval Reference: 2025-P2-170-01). All research was performed in accordance with the Declaration of Helsinki. As this study was a retrospective analysis based on anonymized surveillance data, the need for informed consent was waived by the ethics committee. Consent for publication: This manuscript does not contain any individual person’s data in any form. Therefore, consent for publication is not applicable. Competing interests: The authors declare no competing interests.<br />Background: Epidemiological studies have implicated exposure to PM₂.₅ in the development of pulmonary tuberculosis (PTB); however, the key constituents driving this effect have not been clearly identified.<br />Methods: A time-series analysis spanning 2019 to 2023 was performed across several centers in Beijing to assess the links between major PM <subscript>2.5</subscript> constituents and PTB risk. The effects of five specific components-namely organic matter, black carbon, nitrate, sulfate, and ammonium-were evaluated to pinpoint the most influential factors.<br />Results: All five examined components demonstrated significant relationships with an elevated risk of PTB. Associations were not statistically significant on the same day (lag 0) or the next day (lag 1) after exposure. A clear risk increase was detected starting at a 2-day lag, which was no longer observable by lag 3. Per interquartile range (IQR) rise in the 3-day moving average (lag 0-2) of black carbon and organic matter, the relative risks (RRs) for PTB were 1.11 [95% confidence interval (CI): 1.03, 1.19] and 1.11 (95% CI: 1.03, 1.21), correspondingly. Together, these two components were the dominant drivers of the overall PM₂.₅ effect, contributing 41% and 39% of the joint risk, respectively.<br />Conclusions: The results yield novel evidence that exposure to certain PM <subscript>2.5</subscript> constituents is demonstrated to elevate PTB risk, wherein black carbon and organic matter are established as the principal factors.<br /> (© 2025. The Author(s).) |
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| ISSN: | 1471-2458 |
| DOI: | 10.1186/s12889-025-25116-7 |