Compliance and Satisfaction With a Protocol for Identifying Novel Targets to Support Postpartum Opioid Use Disorder Recovery: Prospective Cohort Study.
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| Titel: | Compliance and Satisfaction With a Protocol for Identifying Novel Targets to Support Postpartum Opioid Use Disorder Recovery: Prospective Cohort Study. |
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| Autoren: | Allen AM; University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR, 72205, United States, 1 5013647377.; Arkansas Children's Research Institute, Little Rock, AR, United States.; Department of Family and Community Medicine, University of Arizona, Tucson, AZ, United States., Linde-Krieger LB; Department of Family and Community Medicine, University of Arizona, Tucson, AZ, United States.; School of Social Work Tucson, Arizona State University, Tucson, AZ, United States., Deschenes J; Department of Family and Community Medicine, University of Arizona, Tucson, AZ, United States., Mallahan S; Clinical Translational Sciences, University of Arizona, Tucson, AZ, United States., Harris A; Department of Family and Community Medicine, University of Arizona, Tucson, AZ, United States., Felix M; Department of Family and Community Medicine, University of Arizona, Tucson, AZ, United States., Chalke A; Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, United States., Anderson A; Department of Family and Community Medicine, University of Arizona, Tucson, AZ, United States., Sharma P; Department of Family and Community Medicine, University of Arizona, Tucson, AZ, United States., King KM; Laboratory for the Evolutionary Endocrinology of Primates, School of Anthropology, University of Arizona, Tucson, AZ, United States., Grant MT; New York Consortium in Evolutionary Primatology, The Graduate Center, CUNY, New York, NY, United States., Baurley J; Biorealm LLC, Monument, CO, United States., Rankin L; School of Social Work Tucson, Arizona State University, Tucson, AZ, United States., Tecot S; Laboratory for the Evolutionary Endocrinology of Primates, School of Anthropology, University of Arizona, Tucson, AZ, United States. |
| Quelle: | JMIR formative research [JMIR Form Res] 2025 Nov 20; Vol. 9, pp. e77899. Date of Electronic Publication: 2025 Nov 20. |
| Publikationsart: | Journal Article |
| Sprache: | English |
| Info zur Zeitschrift: | Publisher: JMIR Publications Country of Publication: Canada NLM ID: 101726394 Publication Model: Electronic Cited Medium: Internet ISSN: 2561-326X (Electronic) Linking ISSN: 2561326X NLM ISO Abbreviation: JMIR Form Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Toronto, ON, Canada : JMIR Publications, [2017]- |
| MeSH-Schlagworte: | Opioid-Related Disorders*/psychology , Opioid-Related Disorders*/therapy , Postpartum Period*/psychology , Patient Satisfaction*/statistics & numerical data , Patient Compliance*/statistics & numerical data , Patient Compliance*/psychology, Humans ; Female ; Prospective Studies ; Adult ; Pregnancy |
| Abstract: | Background: Although treatment for opioid use disorder (OUD) often yields high adherence during pregnancy, the risk of returning to opioid misuse during postpartum is high. There are currently no relapse prevention programs tailored to this unique time period. Using a prospective cohort study, we seek to preliminarily identify hormones or infant caregiving approaches as novel predictors of postpartum opioid misuse. Objective: As a first step in dissemination of results, this report contains a detailed account of the protocol, as well as recruitment, retention, compliance, and participant satisfaction. Methods: Participants were individuals with OUD (OUD+) and those without (OUD-) who were followed from late pregnancy (≥36 gestational wk) to postpartum month 5. From childbirth to postpartum week 12, participants completed daily surveys (capturing use, craving, interactions with infant) and weekly face-to-face visits (including collection of biological samples for hormone assays). Follow-up visits using the same procedures occurred at postpartum month 4 and 5. Results: Most participants (50 OUD+, 20 OUD-) notified the study staff of childbirth (n=63, 93%), completed at least 1 postpartum clinic visit (n=62, 87%), and completed follow-up (n=51, 73%). Compliance with procedures ranged from 81% for weekly surveys to 63% for weekly dried blood spots, generally with lower compliance among OUD+ and at later time points. Among a subgroup of participants (n=31), regardless of group and time point, reported high study satisfaction (eg, on a scale where 0 is "not at all" and 3 is "extremely," on average, participants reported 2.9±0.4 for their willingness to complete this study again at week 12 postpartum). Conclusions: This prospective cohort study was well tolerated despite the challenging postpartum period. Data collected will provide ample opportunities to identify novel risk or protective factors to inform the development of new relapse prevention intervention programs specific to the needs of those with OUD during early postpartum. (© Alicia M Allen, Linnea B Linde-Krieger, Jendar Deschenes, Stephanie Mallahan, Alexandra Harris, Mariana Felix, Arushi Chalke, Alma Anderson, Priyanka Sharma, Katherine M King, Maddy T Grant, James Baurley, Lela Rankin, Stacey Tecot. Originally published in JMIR Formative Research (https://formative.jmir.org).) |
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| Grant Information: | DP2 HD105541 United States HD NICHD NIH HHS; UL1 TR000445 United States TR NCATS NIH HHS |
| Contributed Indexing: | Keywords: cohort study; ecological momentary assessment; hormones; opioid use disorder; postpartum period; pregnancy |
| Entry Date(s): | Date Created: 20251120 Date Completed: 20251120 Latest Revision: 20251124 |
| Update Code: | 20251124 |
| PubMed Central ID: | PMC12633836 |
| DOI: | 10.2196/77899 |
| PMID: | 41264808 |
| Datenbank: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstract: | Background: Although treatment for opioid use disorder (OUD) often yields high adherence during pregnancy, the risk of returning to opioid misuse during postpartum is high. There are currently no relapse prevention programs tailored to this unique time period. Using a prospective cohort study, we seek to preliminarily identify hormones or infant caregiving approaches as novel predictors of postpartum opioid misuse.<br />Objective: As a first step in dissemination of results, this report contains a detailed account of the protocol, as well as recruitment, retention, compliance, and participant satisfaction.<br />Methods: Participants were individuals with OUD (OUD+) and those without (OUD-) who were followed from late pregnancy (≥36 gestational wk) to postpartum month 5. From childbirth to postpartum week 12, participants completed daily surveys (capturing use, craving, interactions with infant) and weekly face-to-face visits (including collection of biological samples for hormone assays). Follow-up visits using the same procedures occurred at postpartum month 4 and 5.<br />Results: Most participants (50 OUD+, 20 OUD-) notified the study staff of childbirth (n=63, 93%), completed at least 1 postpartum clinic visit (n=62, 87%), and completed follow-up (n=51, 73%). Compliance with procedures ranged from 81% for weekly surveys to 63% for weekly dried blood spots, generally with lower compliance among OUD+ and at later time points. Among a subgroup of participants (n=31), regardless of group and time point, reported high study satisfaction (eg, on a scale where 0 is "not at all" and 3 is "extremely," on average, participants reported 2.9±0.4 for their willingness to complete this study again at week 12 postpartum).<br />Conclusions: This prospective cohort study was well tolerated despite the challenging postpartum period. Data collected will provide ample opportunities to identify novel risk or protective factors to inform the development of new relapse prevention intervention programs specific to the needs of those with OUD during early postpartum.<br /> (© Alicia M Allen, Linnea B Linde-Krieger, Jendar Deschenes, Stephanie Mallahan, Alexandra Harris, Mariana Felix, Arushi Chalke, Alma Anderson, Priyanka Sharma, Katherine M King, Maddy T Grant, James Baurley, Lela Rankin, Stacey Tecot. Originally published in JMIR Formative Research (https://formative.jmir.org).) |
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| ISSN: | 2561-326X |
| DOI: | 10.2196/77899 |