Increased risk of thromboembolism in patients with anorexia nervosa: a Danish nationwide registry-based study.
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| Title: | Increased risk of thromboembolism in patients with anorexia nervosa: a Danish nationwide registry-based study. |
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| Authors: | Egedal JM; Center for Eating Disorders, Department of Endocrinology, Odense University Hospital, J.B. Winsløws Vej 4, Odense, DK-5000, Denmark. Jeanie.Meincke.Egedal@rsyd.dk.; Research Unit for Medical Endocrinology, Odense University Hospital, Odense, Denmark. Jeanie.Meincke.Egedal@rsyd.dk.; Research Unit, Child and Adolescent Psychiatry, Mental Health Services in the Region of Southern Denmark, Odense, Denmark. Jeanie.Meincke.Egedal@rsyd.dk.; Mental Health Services, Vejle, Region of Southern Denmark, Denmark. Jeanie.Meincke.Egedal@rsyd.dk.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark. Jeanie.Meincke.Egedal@rsyd.dk., Larsen PV; Mental Health Services, Vejle, Region of Southern Denmark, Denmark., Hallas J; Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark., Sjögren JM; Institute for Clinical Science, Department of Psychiatry, Umeå University, Umeå, Sweden.; National Highly Specialized Unit for Severe Eating Disorders, Umeå, Region West Norrland, Sweden., Bladbjerg EM; Department of Clinical Biochemistry, Unit for Thrombosis Research, University Hospital of Southern Denmark, Esbjerg, Denmark.; Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark., Støving RK; Center for Eating Disorders, Department of Endocrinology, Odense University Hospital, J.B. Winsløws Vej 4, Odense, DK-5000, Denmark.; Research Unit for Medical Endocrinology, Odense University Hospital, Odense, Denmark.; Research Unit, Child and Adolescent Psychiatry, Mental Health Services in the Region of Southern Denmark, Odense, Denmark.; Mental Health Services, Vejle, Region of Southern Denmark, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark. |
| Source: | BMC medicine [BMC Med] 2025 Nov 18; Vol. 23 (1), pp. 640. Date of Electronic Publication: 2025 Nov 18. |
| Publication Type: | Journal Article; Observational Study |
| Language: | English |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [London] : BioMed Central, 2003- |
| MeSH Terms: | Anorexia Nervosa*/complications , Anorexia Nervosa*/epidemiology , Thromboembolism*/epidemiology , Thromboembolism*/etiology, Humans ; Denmark/epidemiology ; Female ; Registries ; Male ; Adolescent ; Young Adult ; Adult ; Risk Factors ; Cohort Studies ; Venous Thromboembolism/epidemiology |
| Abstract: | Competing Interests: Declarations. Ethics approval and consent to participate: Data were available in Statistics Denmark in a pseudonymized form. Approval of the study was given by the Danish Data Protection Agency (file no. 15/280490). By Danish law, ethical approval is not needed for registry-based studies. Access to the data requires application to the Danish authorities and individual approval of data handling. Consent for publication: All authors consent to the publication of this manuscript. As this study is based on anonymized registry data, individual patient consent for publication was not required. Competing interests: The authors declare no competing interests. Background: Case reports suggest an increased risk of both venous thromboembolism and arterial thromboembolism in patients with anorexia nervosa (AN), even in the absence of known risk factors. Population-based studies on thromboembolism in patients with AN are missing. This study aims to establish the association in a registry-based nation-wide data set from Denmark. Methods: This nationwide, observational registry-based cohort study used mandatory health care registries to identify the risk of thromboembolism in a cohort of patients with AN and in population controls matched on date of birth, area of residence, and sex. Thromboembolic outcomes were validated using specific criteria. The two groups were compared using Fine-Gray regression models. Results: In total, 12,676 patients (mean age 18.3 and 93.5% female) were matched with 63,049 controls. Median follow-up time was 9.5 years. For venous thromboembolism, the cumulative risk during the full follow-up period was 0.88% (n = 112) in the AN group and 0.12% (n = 79) in the control group with a subhazard ratio of 7.1 [5.3-9.5]. For arterial thromboembolism, the cumulative risk during the full follow-up period was 0.54% (n = 68) in the AN group and 0.05% (n = 36) in the control group (subhazard ratio 9.5 [6.4-14.1]). Conclusions: Patients with AN have a substantially increased risk of both arterial and venous thromboembolism, compared to the background population. (© 2025. The Author(s).) |
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| Contributed Indexing: | Keywords: Anorexia nervosa; Arterial thromboembolism; Thromboembolic risk; Venous thromboembolism |
| Entry Date(s): | Date Created: 20251119 Date Completed: 20251119 Latest Revision: 20251123 |
| Update Code: | 20251123 |
| PubMed Central ID: | PMC12625379 |
| DOI: | 10.1186/s12916-025-04479-z |
| PMID: | 41254583 |
| Database: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstract: | Competing Interests: Declarations. Ethics approval and consent to participate: Data were available in Statistics Denmark in a pseudonymized form. Approval of the study was given by the Danish Data Protection Agency (file no. 15/280490). By Danish law, ethical approval is not needed for registry-based studies. Access to the data requires application to the Danish authorities and individual approval of data handling. Consent for publication: All authors consent to the publication of this manuscript. As this study is based on anonymized registry data, individual patient consent for publication was not required. Competing interests: The authors declare no competing interests.<br />Background: Case reports suggest an increased risk of both venous thromboembolism and arterial thromboembolism in patients with anorexia nervosa (AN), even in the absence of known risk factors. Population-based studies on thromboembolism in patients with AN are missing. This study aims to establish the association in a registry-based nation-wide data set from Denmark.<br />Methods: This nationwide, observational registry-based cohort study used mandatory health care registries to identify the risk of thromboembolism in a cohort of patients with AN and in population controls matched on date of birth, area of residence, and sex. Thromboembolic outcomes were validated using specific criteria. The two groups were compared using Fine-Gray regression models.<br />Results: In total, 12,676 patients (mean age 18.3 and 93.5% female) were matched with 63,049 controls. Median follow-up time was 9.5 years. For venous thromboembolism, the cumulative risk during the full follow-up period was 0.88% (n = 112) in the AN group and 0.12% (n = 79) in the control group with a subhazard ratio of 7.1 [5.3-9.5]. For arterial thromboembolism, the cumulative risk during the full follow-up period was 0.54% (n = 68) in the AN group and 0.05% (n = 36) in the control group (subhazard ratio 9.5 [6.4-14.1]).<br />Conclusions: Patients with AN have a substantially increased risk of both arterial and venous thromboembolism, compared to the background population.<br /> (© 2025. The Author(s).) |
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| ISSN: | 1741-7015 |
| DOI: | 10.1186/s12916-025-04479-z |