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Small RNAs big impact: a review on microRNA-mediated tolerance in wheat under terminal heat.

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Titel:	Small RNAs big impact: a review on microRNA-mediated tolerance in wheat under terminal heat.
Autoren:	Warkad S; Division of Biochemistry, New Delhi, India., Kumar A; Division of Biochemistry, New Delhi, India., Gampa M; Division of Biochemistry, New Delhi, India., Goswami S; Division of Biochemistry, New Delhi, India., T V; Division of Biochemistry, New Delhi, India., Kumar S; Division of Plant Physiology, ICAR-Indian Agricultural Research Institute, New Delhi, 110012, India., Dalal M; ICAR- National Institute of Plant Biotechnology, New Delhi, 110012, India., Mishra D; ICAR- Indian Agricultural Statistics Research Institute, New Delhi, 110012, India., Jha GK; ICAR- Indian Agricultural Statistics Research Institute, New Delhi, 110012, India., C V; Division of Plant Physiology, ICAR-Indian Agricultural Research Institute, New Delhi, 110012, India., Kumar RR; Division of Biochemistry, New Delhi, India. ranjeetranjaniari@gmail.com.
Quelle:	Functional & integrative genomics [Funct Integr Genomics] 2025 Nov 18; Vol. 25 (1), pp. 245. Date of Electronic Publication: 2025 Nov 18.
Publikationsart:	Journal Article; Review
Sprache:	English
Info zur Zeitschrift:	Publisher: Springer Country of Publication: Germany NLM ID: 100939343 Publication Model: Electronic Cited Medium: Internet ISSN: 1438-7948 (Electronic) Linking ISSN: 1438793X NLM ISO Abbreviation: Funct Integr Genomics Subsets: MEDLINE
Imprint Name(s):	Original Publication: Berlin : Springer, c2000-
MeSH-Schlagworte:	Triticum/genetics , Triticum/physiology , MicroRNAs/genetics , MicroRNAs/metabolism , Thermotolerance/genetics , Heat-Shock Response/genetics , RNA, Plant/genetics , RNA, Plant/metabolism, Gene Expression Regulation, Plant ; CRISPR-Cas Systems
Abstract:	Competing Interests: Declarations. Ethics: Not applicable. Competing interests: The authors declare no competing interests. MicroRNAs (miRNAs) are key regulators of gene expression in plant responses to abiotic stresses, including heat stress. High temperatures during the critical developmental stages of wheat (Triticum aestivum L.) drastically limit growth and production. Recent research has found that specific miRNAs regulate molecular complexes and physiological responses by targeting transcription factors, heat shock proteins, and signaling components, thereby modulating heat stress tolerance pathways. This review highlights current knowledge about heat-responsive miRNAs in wheat, including their validated targets and functional involvement in thermotolerance. In addition, we summarized the potential CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats /CRISPR associated protein 9) genome editing tool for precise alteration of miRNA genes or their targets, degradome profiling, the secondary structure of miRNA, and how interplay of miRNAs with HSFs and HSPs in target gene regulation to improve heat resilience. A comprehensive understanding of miRNA-regulated networks presents novel possibilities for developing climate-resilient wheat varieties, thereby ensuring food security in the face of global warming. (© 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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Grant Information:	CABin Indian Council of Agricultural Research; NICRA Indian Council of Agricultural Research
Contributed Indexing:	Keywords: Heat shock proteins (HSPs); Heat transcription factors (HSFs); MicroRNAs (miRNAs); Target gene regulation; Terminal heat stress; Thermotolerance; Wheat
Substance Nomenclature:	0 (MicroRNAs) 0 (RNA, Plant)
Entry Date(s):	Date Created: 20251117 Date Completed: 20251118 Latest Revision: 20251117
Update Code:	20251118
DOI:	10.1007/s10142-025-01749-0
PMID:	41249545
Datenbank:	MEDLINE

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Abstract:	Competing Interests: Declarations. Ethics: Not applicable. Competing interests: The authors declare no competing interests.<br />MicroRNAs (miRNAs) are key regulators of gene expression in plant responses to abiotic stresses, including heat stress. High temperatures during the critical developmental stages of wheat (Triticum aestivum L.) drastically limit growth and production. Recent research has found that specific miRNAs regulate molecular complexes and physiological responses by targeting transcription factors, heat shock proteins, and signaling components, thereby modulating heat stress tolerance pathways. This review highlights current knowledge about heat-responsive miRNAs in wheat, including their validated targets and functional involvement in thermotolerance. In addition, we summarized the potential CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats /CRISPR associated protein 9) genome editing tool for precise alteration of miRNA genes or their targets, degradome profiling, the secondary structure of miRNA, and how interplay of miRNAs with HSFs and HSPs in target gene regulation to improve heat resilience. A comprehensive understanding of miRNA-regulated networks presents novel possibilities for developing climate-resilient wheat varieties, thereby ensuring food security in the face of global warming.<br /> (© 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
ISSN:	1438-7948
DOI:	10.1007/s10142-025-01749-0