Risk for neurocognitive impairment in Korean childhood cancer survivors.
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| Title: | Risk for neurocognitive impairment in Korean childhood cancer survivors. |
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| Authors: | Lee YS; Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., Jeong SM; Department of Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Sung KW; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., Lee JW; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., Baek HJ; Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea., Chung NG; Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Shin DW; Department of Family Medicine, Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, 06351, Seoul, Republic of Korea., Song YM; Department of Family Medicine, Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, 06351, Seoul, Republic of Korea. yunmisong@skku.edu. |
| Source: | Scientific reports [Sci Rep] 2025 Nov 14; Vol. 15 (1), pp. 39906. Date of Electronic Publication: 2025 Nov 14. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| MeSH Terms: | Cancer Survivors*/psychology , Cognitive Dysfunction*/epidemiology , Cognitive Dysfunction*/etiology , Neurocognitive Disorders*/epidemiology , Neurocognitive Disorders*/etiology , Neoplasms*/complications, Humans ; Male ; Female ; Adolescent ; Republic of Korea/epidemiology ; Child ; Young Adult ; Risk Factors ; Siblings ; Surveys and Questionnaires ; Adult ; Prevalence |
| Abstract: | Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Background Neurocognitive impairment is one of the serious treatment-related late complications of childhood cancer survivors (CCS). This study aimed to evaluate neurocognitive impairment of Korean CCS at their adolescent and young age for whom little was known. Method We recruited 720 Korean CCS diagnosed with primary cancer before the age of 19 years and 222 siblings of CCS. We measured neurocognitive function using the Korean version of Neurocognitive Questionnaire (K-NCQ) composed of four subdomains, with cut-off level of impairment set at the upper 10% of score distribution among sibling group. We evaluated the risk of neurocognitive impairment in CCS as compared with sibling by multiple logistic regression analysis. Results Average (standard deviation) ages of CCS at cancer diagnosis and at survey was 9.3 (5.3) and 17.6 (5.1) years, respectively. Compared with siblings, prevalence and adjusted odds ratio (95% confidence interval) of neurocognitive impairment were significantly higher in CCS with CNS solid tumor for task efficiency (31.5% vs. 16.2%, 2.58(1.47, 4.50)) and organization (24.1% vs. 13.5%, 2.70(1.44, 5.07)) subdomains. Consistent findings were observed in the subgroup analysis of 156 CCS with sibling participants and their siblings (n = 183). However, CCS with non-CNS solid tumor or hematologic malignancy showed no increased risk of impairment for four subdomains of K-NCQ. Conclusion Young-aged Korean CNS solid tumor survivors may have a higher risk of neurocognitive impairment for task efficiency and organization subdomains. However, neurocognitive function for memory and emotional regulation subdomains did not differ between CCS and siblings. (© 2025. The Author(s).) |
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| Grant Information: | 1720270 the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea; 1720270 the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea; 1720270 the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea |
| Contributed Indexing: | Keywords: Cancer survivors; Child; Neurocognitive disorders; Republic of korea |
| Entry Date(s): | Date Created: 20251114 Date Completed: 20251114 Latest Revision: 20251117 |
| Update Code: | 20251117 |
| PubMed Central ID: | PMC12618568 |
| DOI: | 10.1038/s41598-025-23709-1 |
| PMID: | 41238667 |
| Database: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstract: | Competing Interests: Declarations. Competing interests: The authors declare no competing interests.<br />Background Neurocognitive impairment is one of the serious treatment-related late complications of childhood cancer survivors (CCS). This study aimed to evaluate neurocognitive impairment of Korean CCS at their adolescent and young age for whom little was known. Method We recruited 720 Korean CCS diagnosed with primary cancer before the age of 19 years and 222 siblings of CCS. We measured neurocognitive function using the Korean version of Neurocognitive Questionnaire (K-NCQ) composed of four subdomains, with cut-off level of impairment set at the upper 10% of score distribution among sibling group. We evaluated the risk of neurocognitive impairment in CCS as compared with sibling by multiple logistic regression analysis. Results Average (standard deviation) ages of CCS at cancer diagnosis and at survey was 9.3 (5.3) and 17.6 (5.1) years, respectively. Compared with siblings, prevalence and adjusted odds ratio (95% confidence interval) of neurocognitive impairment were significantly higher in CCS with CNS solid tumor for task efficiency (31.5% vs. 16.2%, 2.58(1.47, 4.50)) and organization (24.1% vs. 13.5%, 2.70(1.44, 5.07)) subdomains. Consistent findings were observed in the subgroup analysis of 156 CCS with sibling participants and their siblings (n = 183). However, CCS with non-CNS solid tumor or hematologic malignancy showed no increased risk of impairment for four subdomains of K-NCQ. Conclusion Young-aged Korean CNS solid tumor survivors may have a higher risk of neurocognitive impairment for task efficiency and organization subdomains. However, neurocognitive function for memory and emotional regulation subdomains did not differ between CCS and siblings.<br /> (© 2025. The Author(s).) |
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| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-025-23709-1 |