Neural and molecular changes during a mind-body reconceptualization, meditation, and open label placebo healing intervention.
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| Názov: | Neural and molecular changes during a mind-body reconceptualization, meditation, and open label placebo healing intervention. |
|---|---|
| Autori: | Jinich-Diamant A; Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA.; Department of Cognitive Science, University of California San Diego, La Jolla, CA, USA., Simpson S; Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA., Zuniga-Hertz JP; Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA., Chitteti R; Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA., Schilling JM; Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA., Bonds JA; Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA., Case L; Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA., Chernov AV; Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA.; Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA., Dispenza J; Metamorphosis LLC, Ranier, WA, USA., Maree J; VitaMed Research, Palm Desert, CA, USA., Amkie Stahl NE; Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA., Licamele M; Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA., Fazlalipour N; Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA., Devulapalli S; Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA., Christov-Moore L; Institute for Advanced Consciousness Studies, Santa Monica, CA, USA., Reggente N; Institute for Advanced Consciousness Studies, Santa Monica, CA, USA., Poirier MA; Metamorphosis LLC, Ranier, WA, USA., Moeller-Bertram T; VitaMed Research, Palm Desert, CA, USA., Patel HH; Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA. hepatel@health.ucsd.edu.; Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA. hepatel@health.ucsd.edu. |
| Zdroj: | Communications biology [Commun Biol] 2025 Nov 06; Vol. 8 (1), pp. 1525. Date of Electronic Publication: 2025 Nov 06. |
| Spôsob vydávania: | Journal Article; Observational Study |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London, United Kingdom : Nature Publishing Group UK, [2018]- |
| Výrazy zo slovníka MeSH: | Meditation* , Mind-Body Therapies*/methods , Brain*/physiology , Brain*/metabolism , Brain*/diagnostic imaging, Humans ; Male ; Adult ; Female ; Magnetic Resonance Imaging ; MicroRNAs/genetics ; Middle Aged ; Young Adult |
| Abstrakt: | Competing Interests: Competing interests: The authors declare the following competing interest: J.D. is employed by Encephalon, Inc., which offers the meditation retreats. All other authors declare no competing interests. Mind-body interventions offer promising avenues for improving physical and mental health, yet the comprehensive biological effects of increasingly popular mind-body retreat interventions remain poorly understood. The neural and molecular effects of a 7-day retreat intervention combining meditation, reconceptualization, and open-label placebo healing rituals are investigated in an observational study on 20 healthy human participants randomly selected from 561 retreat participants. BOLD fMRI functional connectivity during rest and meditation and whole plasma proteomics, metabolomics, exosome-specific miRNA transcriptomics, and neurite growth and real-time metabolism cellular assays are compared pre- and post-intervention. Meditation decreases functional integration in the default mode (p = 0.00009) and salience networks (p = 0.000003) and decreases whole-brain modularity (p = 0.001). Compared to pre-intervention plasma, post plasma increases in vitro neurite outgrowth (p = 0.01), enhances glycolytic metabolism (p = 0.008), induces upregulation of BDNF (p = 0.001), inflammatory (p = 0.0001), anti-inflammatory (p = 0.03), and endogenous opioid (p = 0.03) pathways, and modulates tryptophan metabolism (p (© 2025. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.) |
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| Grant Information: | IK6 BX005229 United States BX BLRD VA |
| Substance Nomenclature: | 0 (MicroRNAs) |
| Entry Date(s): | Date Created: 20251106 Date Completed: 20251106 Latest Revision: 20251111 |
| Update Code: | 20251111 |
| PubMed Central ID: | PMC12592435 |
| DOI: | 10.1038/s42003-025-09088-3 |
| PMID: | 41198896 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Competing Interests: Competing interests: The authors declare the following competing interest: J.D. is employed by Encephalon, Inc., which offers the meditation retreats. All other authors declare no competing interests.<br />Mind-body interventions offer promising avenues for improving physical and mental health, yet the comprehensive biological effects of increasingly popular mind-body retreat interventions remain poorly understood. The neural and molecular effects of a 7-day retreat intervention combining meditation, reconceptualization, and open-label placebo healing rituals are investigated in an observational study on 20 healthy human participants randomly selected from 561 retreat participants. BOLD fMRI functional connectivity during rest and meditation and whole plasma proteomics, metabolomics, exosome-specific miRNA transcriptomics, and neurite growth and real-time metabolism cellular assays are compared pre- and post-intervention. Meditation decreases functional integration in the default mode (p = 0.00009) and salience networks (p = 0.000003) and decreases whole-brain modularity (p = 0.001). Compared to pre-intervention plasma, post plasma increases in vitro neurite outgrowth (p = 0.01), enhances glycolytic metabolism (p = 0.008), induces upregulation of BDNF (p = 0.001), inflammatory (p = 0.0001), anti-inflammatory (p = 0.03), and endogenous opioid (p = 0.03) pathways, and modulates tryptophan metabolism (p <subscript>FDR</subscript> = 0.03) and neurotransmission-associated exosome miRNA transcripts. This intensive non-pharmacological mind-body intervention produces broad short-term neural and plasma-based molecular changes associated with enhanced neuroplasticity, metabolic reprogramming, and modulation of functional cell signaling pathways, highlighting the potential of mind-body techniques to modulate neural circuits and pathways important to health and well-being.<br /> (© 2025. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.) |
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| ISSN: | 2399-3642 |
| DOI: | 10.1038/s42003-025-09088-3 |