Reservoir host community and vector density predict human tick-borne diseases across the Eastern United States.
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| Názov: | Reservoir host community and vector density predict human tick-borne diseases across the Eastern United States. |
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| Autori: | Martins PM; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA. paulomateusms@gmail.com.; 100 Galvin Life Sciences, University of Notre Dame, Notre Dame, IN, 46556, USA. paulomateusms@gmail.com., Mahon MB; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA., Rohr JR; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA. |
| Zdroj: | Scientific reports [Sci Rep] 2025 Nov 05; Vol. 15 (1), pp. 38794. Date of Electronic Publication: 2025 Nov 05. |
| Spôsob vydávania: | Journal Article |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| Výrazy zo slovníka MeSH: | Tick-Borne Diseases*/epidemiology , Tick-Borne Diseases*/transmission , Disease Reservoirs* , Arachnid Vectors*, Humans ; Animals ; United States/epidemiology ; Lyme Disease/epidemiology ; Lyme Disease/transmission ; Anaplasmosis/epidemiology ; Anaplasmosis/transmission ; Babesiosis/epidemiology ; Babesiosis/transmission ; Ticks/microbiology ; Deer/parasitology ; Incidence ; Ehrlichiosis/epidemiology ; Ehrlichiosis/transmission |
| Abstrakt: | Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Tick-borne disease (TBD) incidence is rising globally, underscoring the need for prevention strategies that consider ecological drivers of transmission. We analyzed associations between human reported cases of four TBDs and ecological and climatic factors across 24 eastern U.S. counties. Mean reported cases per 100,000 people were 0.0274 for Lyme disease, 0.0045 for anaplasmosis, 0.0012 for ehrlichiosis, and 0.0005 for babesiosis. Babesiosis was negatively associated with mean annual temperature, whereas ehrlichiosis increased with nymphal tick density. Anaplasmosis was positively linked to tick density, with the abundance of competent hosts mediating the effects of small-mammal richness. Lyme disease was positively associated with deer density and negatively associated with precipitation, temperature, and small-mammal richness. We also found a positive interaction between competent host abundance and tick density as drivers of Lyme disease. Our results support the dilution-effect hypothesis for Lyme disease and a mediating effect of host composition for anaplasmosis dilution or amplification. Our findings highlight that ecological context strongly shapes TBD risk, suggesting that the effectiveness of intervention strategies depends on interactions among ticks, hosts, and climate. (© 2025. The Author(s).) |
| References: | Trends Parasitol. 2016 Aug;32(8):646-656. (PMID: 27260548) Ecol Lett. 2015 Oct;18(10):1119-33. (PMID: 26261049) J Med Entomol. 2012 Jan;49(1):11-22. (PMID: 22308766) Philos Trans R Soc Lond B Biol Sci. 2015 Apr 5;370(1665):. (PMID: 25688022) Ecology. 2018 Jul;99(7):1562-1573. (PMID: 29738078) Philos Trans R Soc Lond B Biol Sci. 2017 Jun 5;372(1722):. (PMID: 28438920) Ticks Tick Borne Dis. 2019 Apr;10(3):553-563. (PMID: 30709659) Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):567-71. (PMID: 12525705) PLoS One. 2015 Feb 04;10(2):e0116767. (PMID: 25650808) JAMA. 2016 Apr 26;315(16):1767-77. (PMID: 27115378) Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10942-7. (PMID: 22711825) Emerg Infect Dis. 2022 May;28(5):957-966. (PMID: 35447066) J Med Entomol. 2008 Jan;45(1):139-47. (PMID: 18283955) Ticks Tick Borne Dis. 2023 Nov;14(6):102233. (PMID: 37494882) Clin Infect Dis. 2020 Jul 11;71(2):440-452. (PMID: 31773171) Trends Ecol Evol. 2013 Apr;28(4):239-47. (PMID: 23182683) JAMA Neurol. 2024 Feb 1;81(2):188-189. (PMID: 38147320) PLoS One. 2019 Jan 4;14(1):e0210280. (PMID: 30608986) Parasitology. 2012 Jun;139(7):847-63. (PMID: 22336330) Parasit Vectors. 2015 Mar 15;8:161. (PMID: 25889086) Can J Infect Dis Med Microbiol. 2019 Sep 16;2019:9817930. (PMID: 31636771) Nat Commun. 2019 Nov 6;10(1):5032. (PMID: 31695043) PLoS Biol. 2021 Jan 28;19(1):e3001066. (PMID: 33507921) J Med Entomol. 2006 Mar;43(2):166-76. (PMID: 16619595) PLoS One. 2019 Jan 2;14(1):e0209082. (PMID: 30601855) PeerJ. 2020 Jan 22;8:e8262. (PMID: 32002322) J Med Entomol. 2014 Jul;51(4):777-84. (PMID: 25118409) Lancet. 2012 Dec 1;380(9857):1946-55. (PMID: 23200503) Am J Prev Med. 2009 Sep;37(3):201-6. (PMID: 19595558) Am J Trop Med Hyg. 2014 Aug;91(2):302-9. (PMID: 24865688) Emerg Infect Dis. 2010 Mar;16(3):433-40. (PMID: 20202418) Psychometrika. 2013 Oct;78(4):685-709. (PMID: 24092484) Eur J Public Health. 2015 Dec;25(6):1071-8. (PMID: 26082446) J R Soc Interface. 2017 Sep;14(134):. (PMID: 28904005) Am J Trop Med Hyg. 2012 Jun;86(6):1062-71. (PMID: 22665620) Clin Infect Dis. 2014 Sep 1;59(5):676-81. (PMID: 24879782) Nat Ecol Evol. 2020 Jan;4(1):24-33. (PMID: 31819238) Glob Chang Biol. 2021 Feb;27(4):738-754. (PMID: 33150704) Microorganisms. 2023 Dec 27;12(1):. (PMID: 38257877) Parasit Vectors. 2021 Sep 30;14(1):509. (PMID: 34593023) Ticks Tick Borne Dis. 2024 May;15(3):102316. (PMID: 38325243) |
| Contributed Indexing: | Keywords: Disease ecology; Diversity-disease; Reservoir community competence; Tick-borne disease; Zoonoses |
| Entry Date(s): | Date Created: 20251105 Date Completed: 20251105 Latest Revision: 20251108 |
| Update Code: | 20251108 |
| PubMed Central ID: | PMC12589401 |
| DOI: | 10.1038/s41598-025-22637-4 |
| PMID: | 41193551 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Competing Interests: Declarations. Competing interests: The authors declare no competing interests.<br />Tick-borne disease (TBD) incidence is rising globally, underscoring the need for prevention strategies that consider ecological drivers of transmission. We analyzed associations between human reported cases of four TBDs and ecological and climatic factors across 24 eastern U.S. counties. Mean reported cases per 100,000 people were 0.0274 for Lyme disease, 0.0045 for anaplasmosis, 0.0012 for ehrlichiosis, and 0.0005 for babesiosis. Babesiosis was negatively associated with mean annual temperature, whereas ehrlichiosis increased with nymphal tick density. Anaplasmosis was positively linked to tick density, with the abundance of competent hosts mediating the effects of small-mammal richness. Lyme disease was positively associated with deer density and negatively associated with precipitation, temperature, and small-mammal richness. We also found a positive interaction between competent host abundance and tick density as drivers of Lyme disease. Our results support the dilution-effect hypothesis for Lyme disease and a mediating effect of host composition for anaplasmosis dilution or amplification. Our findings highlight that ecological context strongly shapes TBD risk, suggesting that the effectiveness of intervention strategies depends on interactions among ticks, hosts, and climate.<br /> (© 2025. The Author(s).) |
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| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-025-22637-4 |