Humans and microbes: A systems theory perspective on coevolution.
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| Názov: | Humans and microbes: A systems theory perspective on coevolution. |
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| Autori: | Melkikh AV; Ural Federal University, Yekaterinburg, Russia. Electronic address: melkikh2014@gmail.com. |
| Zdroj: | Bio Systems [Biosystems] 2025 Dec; Vol. 258, pp. 105639. Date of Electronic Publication: 2025 Oct 30. |
| Spôsob vydávania: | Journal Article; Review |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 0430773 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8324 (Electronic) Linking ISSN: 03032647 NLM ISO Abbreviation: Biosystems Subsets: MEDLINE |
| Imprint Name(s): | Publication: Limerick : Elsevier Science Ireland Original Publication: Amsterdam, North-Holland Pub. Co. |
| Výrazy zo slovníka MeSH: | Systems Theory* , Biological Evolution* , Adaptation, Physiological*/genetics , Evolution, Molecular* , Biological Coevolution*, Humans ; Bacteria/genetics ; Gene Transfer, Horizontal ; Mutation ; Fungi/genetics |
| Abstrakt: | Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The issue of rapid adaptation of microorganisms to changing environments is examined. The mechanism of adaptive mutations is analyzed. The possibility that horizontal gene transfer is a random process is discussed. Bacteria, unicellular fungi, and other microorganisms successfully adapt to fast-changing conditions (such as exposure to drugs) because their evolution is not a random process. Adaptation to antibiotics, adaptive mutations, and related phenomena occur because microbial evolution is inherently directed and purposefully oriented toward potential external changes. Rejecting gene-centricity plays a crucial role in understanding the coevolution of humans and pathogens. This means that beyond genes, there exists a higher-level system-an organism with its own unique properties that cannot be reduced to genes. The problem of human adaptation to infectious agents (viruses, bacteria, and protozoa) is also analyzed. Based on general systems theory, it is concluded that humans and pathogens coevolve in a controlled manner. (Copyright © 2025 Elsevier B.V. All rights reserved.) |
| Contributed Indexing: | Keywords: Bacteria; Directed evolution; Drug resistance; Horizontal gene transfer; Systems theory; Viruses |
| Entry Date(s): | Date Created: 20251101 Date Completed: 20251116 Latest Revision: 20251116 |
| Update Code: | 20251117 |
| DOI: | 10.1016/j.biosystems.2025.105639 |
| PMID: | 41176022 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br />The issue of rapid adaptation of microorganisms to changing environments is examined. The mechanism of adaptive mutations is analyzed. The possibility that horizontal gene transfer is a random process is discussed. Bacteria, unicellular fungi, and other microorganisms successfully adapt to fast-changing conditions (such as exposure to drugs) because their evolution is not a random process. Adaptation to antibiotics, adaptive mutations, and related phenomena occur because microbial evolution is inherently directed and purposefully oriented toward potential external changes. Rejecting gene-centricity plays a crucial role in understanding the coevolution of humans and pathogens. This means that beyond genes, there exists a higher-level system-an organism with its own unique properties that cannot be reduced to genes. The problem of human adaptation to infectious agents (viruses, bacteria, and protozoa) is also analyzed. Based on general systems theory, it is concluded that humans and pathogens coevolve in a controlled manner.<br /> (Copyright © 2025 Elsevier B.V. All rights reserved.) |
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| ISSN: | 1872-8324 |
| DOI: | 10.1016/j.biosystems.2025.105639 |