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A Cohort Study on Alzheimer's Disease in Relation to Residential Magnetic Fields From Indoor Transformer Stations.

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Titel: A Cohort Study on Alzheimer's Disease in Relation to Residential Magnetic Fields From Indoor Transformer Stations.
Autoren: Liimatainen A; Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Pohjois-Savo, Finland.; Radiation Practices Regulation, Radiation and Nuclear Safety Authority, Vantaa, Uusimaa, Finland., Roivainen P; Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Pohjois-Savo, Finland., Juutilainen J; Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Pohjois-Savo, Finland., Höytö A; Radiation Practices Regulation, Radiation and Nuclear Safety Authority, Vantaa, Uusimaa, Finland., Naarala J; Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Pohjois-Savo, Finland.
Quelle: Bioelectromagnetics [Bioelectromagnetics] 2025 Dec; Vol. 46 (8), pp. e70031.
Publikationsart: Journal Article
Sprache: English
Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8008281 Publication Model: Print Cited Medium: Internet ISSN: 1521-186X (Electronic) Linking ISSN: 01978462 NLM ISO Abbreviation: Bioelectromagnetics Subsets: MEDLINE
Imprint Name(s): Publication: New York, NY : Wiley-Liss
Original Publication: New York, Liss.
MeSH-Schlagworte: Alzheimer Disease*/epidemiology , Alzheimer Disease*/etiology , Magnetic Fields*/adverse effects , Environmental Exposure*/adverse effects , Housing*, Humans ; Male ; Female ; Aged ; Cohort Studies ; Proportional Hazards Models ; Middle Aged ; Aged, 80 and over
Abstract: Meta-analyses of epidemiological studies have suggested that Alzheimer's disease (AD) may be linked with exposure to extremely low frequency (ELF) magnetic fields (MF). This is the first study investigating the association of AD with exposure to residential ELF MFs from indoor transformer stations, using a study design that avoids shortcomings of previous studies. All cohort members had lived in buildings with indoor transformer stations. MF exposure was assessed based on the location of their apartment in relation to the transformer room. AD patients were identified from Drug Purchase Register and Drug Reimbursement Register. Out of the 155,562 individuals, 5652 (111,357 person-years of follow-up) living in apartments next to transformer stations were considered as exposed, while 115,772 (2,289,526 person-years of follow-up) individuals living on higher floors of the same buildings were considered as referents. Associations between MF exposure and AD were examined using Cox proportional hazard models. The hazard ratio (HR) was 1.02 (95% confidence interval: 0.85-1.22), indicating that the risk of AD is not associated with residential ELF MFs present in apartments next to transformer stations. The duration of residence did not essentially change the HR. The risk of AD was slightly but not statistically significantly higher (HR 1.22, 95% confidence interval: 0.94-1.57) for those whose residence started before the age of 50 years. The results did not support positive findings from previous studies that have reported a link between AD and occupational or residential MF exposure. Bioelectromagnetics. 00:00-00, 2025.
(© 2025 The Author(s). Bioelectromagnetics published by Wiley Periodicals LLC on behalf of Bioelectromagnetics Society.)
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Grant Information: This work was supported by Radiation and Nuclear Safety Authority and Juho Vainio Foundation.
Contributed Indexing: Keywords: Alzheimer's disease; electromagnetic fields; environmental exposure; epidemiology; nonionizing radiation
Entry Date(s): Date Created: 20251031 Date Completed: 20251031 Latest Revision: 20251103
Update Code: 20251103
PubMed Central ID: PMC12576762
DOI: 10.1002/bem.70031
PMID: 41170624
Datenbank: MEDLINE
Beschreibung
Abstract:Meta-analyses of epidemiological studies have suggested that Alzheimer's disease (AD) may be linked with exposure to extremely low frequency (ELF) magnetic fields (MF). This is the first study investigating the association of AD with exposure to residential ELF MFs from indoor transformer stations, using a study design that avoids shortcomings of previous studies. All cohort members had lived in buildings with indoor transformer stations. MF exposure was assessed based on the location of their apartment in relation to the transformer room. AD patients were identified from Drug Purchase Register and Drug Reimbursement Register. Out of the 155,562 individuals, 5652 (111,357 person-years of follow-up) living in apartments next to transformer stations were considered as exposed, while 115,772 (2,289,526 person-years of follow-up) individuals living on higher floors of the same buildings were considered as referents. Associations between MF exposure and AD were examined using Cox proportional hazard models. The hazard ratio (HR) was 1.02 (95% confidence interval: 0.85-1.22), indicating that the risk of AD is not associated with residential ELF MFs present in apartments next to transformer stations. The duration of residence did not essentially change the HR. The risk of AD was slightly but not statistically significantly higher (HR 1.22, 95% confidence interval: 0.94-1.57) for those whose residence started before the age of 50 years. The results did not support positive findings from previous studies that have reported a link between AD and occupational or residential MF exposure. Bioelectromagnetics. 00:00-00, 2025.<br /> (© 2025 The Author(s). Bioelectromagnetics published by Wiley Periodicals LLC on behalf of Bioelectromagnetics Society.)
ISSN:1521-186X
DOI:10.1002/bem.70031