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The effect of acupuncture-related therapies in animal model of postmenopausal osteoporosis: a meta-analysis and data mining approach.

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Titel: The effect of acupuncture-related therapies in animal model of postmenopausal osteoporosis: a meta-analysis and data mining approach.
Autoren: Yu G; Shenzhen Bao'an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China.; Clinical Medical School of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Gao Y; Clinical Medical School of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Song H; Clinical Medical School of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Chen G; Shenzhen Bao'an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China., Xu Y; Clinical Medical School of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Quelle: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2025 Oct 15; Vol. 16, pp. 1617154. Date of Electronic Publication: 2025 Oct 15 (Print Publication: 2025).
Publikationsart: Journal Article; Meta-Analysis; Systematic Review
Sprache: English
Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
Imprint Name(s): Original Publication: [Lausanne : Frontiers Research Foundation]
MeSH-Schlagworte: Acupuncture Therapy*/methods , Osteoporosis, Postmenopausal*/therapy , Data Mining*/methods, Animals ; Disease Models, Animal ; Female ; Bone Density ; Humans ; Acupuncture Points
Abstract: Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Purpose: This meta-analysis and data mining aimed to investigate the effectiveness of Acupuncture-Related Therapies for animal models with Postmenopausal Osteoporosis (POMP) and to summarize the acupoints involved.
Methods: This systematic review was conducted a comprehensive search of animal experiments using acupuncture-related therapies for the treatment of PMOP up to April 1, 2025. The primary outcome was bone mineral density (BMD). The secondary outcome indicators were estradiol(E 2 ), blood calcium, osteocalcin(OC) and alkaline phosphatas(ALP).Meta-analysis was used to evaluate its efficacy, and data mining was used to explore the protocol for acupoint selection.
Results: 27 Animal Experiments encompassing 548 animals with PMOP were analyzed. Meta-analysis displayed that compared with the conventional drug group, the acupuncture-related therapy group significantly increased the Estradiol (mean difference [MD] 2.37,95% confidence interval [95%CI] 1.15 to 3.58), Femoral BMD (mean difference [MD] 1.25,95% confidence interval [95%CI] 0.65 to 1.87), lumbar BMD (mean difference [MD] 1.88,95% confidence interval [95%CI] 1.27 to 2.49), Tibia BMD (mean difference [MD] 1.63,95% confidence interval [95%CI] 0.56 to 2.69). Data mining revealed that Zusanli (ST36), Shenshu (BL23), Guanyuan (CV4), and Sanyinjiao (SP6) were the core acupoints for PMOP treated by Acupuncture-Related Therapies.
Conclusion: Acupuncture improved BMD and estrogen levels in animal models of PMOP. ST36, BL23, CV4, and SP6 are the core acupoints for acupuncture in PMOP, and this program is expected to become a supplementary treatment for PMOP.
(Copyright © 2025 Yu, Gao, Song, Chen and Xu.)
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Contributed Indexing: Keywords: acupoint; acupuncture; data mining; meta-analysis; postmenopausal osteoporosis
Entry Date(s): Date Created: 20251031 Date Completed: 20251031 Latest Revision: 20251102
Update Code: 20251102
PubMed Central ID: PMC12568401
DOI: 10.3389/fendo.2025.1617154
PMID: 41169461
Datenbank: MEDLINE
Beschreibung
Abstract:Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br />Purpose: This meta-analysis and data mining aimed to investigate the effectiveness of Acupuncture-Related Therapies for animal models with Postmenopausal Osteoporosis (POMP) and to summarize the acupoints involved.<br />Methods: This systematic review was conducted a comprehensive search of animal experiments using acupuncture-related therapies for the treatment of PMOP up to April 1, 2025. The primary outcome was bone mineral density (BMD). The secondary outcome indicators were estradiol(E <subscript>2</subscript> ), blood calcium, osteocalcin(OC) and alkaline phosphatas(ALP).Meta-analysis was used to evaluate its efficacy, and data mining was used to explore the protocol for acupoint selection.<br />Results: 27 Animal Experiments encompassing 548 animals with PMOP were analyzed. Meta-analysis displayed that compared with the conventional drug group, the acupuncture-related therapy group significantly increased the Estradiol (mean difference [MD] 2.37,95% confidence interval [95%CI] 1.15 to 3.58), Femoral BMD (mean difference [MD] 1.25,95% confidence interval [95%CI] 0.65 to 1.87), lumbar BMD (mean difference [MD] 1.88,95% confidence interval [95%CI] 1.27 to 2.49), Tibia BMD (mean difference [MD] 1.63,95% confidence interval [95%CI] 0.56 to 2.69). Data mining revealed that Zusanli (ST36), Shenshu (BL23), Guanyuan (CV4), and Sanyinjiao (SP6) were the core acupoints for PMOP treated by Acupuncture-Related Therapies.<br />Conclusion: Acupuncture improved BMD and estrogen levels in animal models of PMOP. ST36, BL23, CV4, and SP6 are the core acupoints for acupuncture in PMOP, and this program is expected to become a supplementary treatment for PMOP.<br /> (Copyright © 2025 Yu, Gao, Song, Chen and Xu.)
ISSN:1664-2392
DOI:10.3389/fendo.2025.1617154