"The cytokine profiles of the inflammatory response in chronic granulomatous encephalitis caused by Mycobacterium tuberculosis do not influence the patient's clinical presentation".
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| Title: | "The cytokine profiles of the inflammatory response in chronic granulomatous encephalitis caused by Mycobacterium tuberculosis do not influence the patient's clinical presentation". |
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| Authors: | Rivas-Castro A; Red MEDICI, Carrera de Médico Cirujano, FESI, UNAM, State of Mexico, Mexico; Centro de Innovación Educativa en Medicina y Simulación Clínica (CIEMSiC), Facultad Mexicana de Medicina, Universidad La Salle, Mexico City, Mexico., Manzano Espinosa IR; Red MEDICI, Carrera de Médico Cirujano, FESI, UNAM, State of Mexico, Mexico., Sepúlveda DV; Departamento de Neuropatología, Hospital General de México 'Dr. Eduardo Liceaga', Mexico City, Mexico., Martínez EPS; UMFH Clínica 22 'El Dorado' / Hospital General de Culiacán, Sinaloa, Mexico., Choreño-Parra JA; Departamento de Enseñanza, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, 14080, Mexico City, Mexico., Gama YS; Harvard Medical School, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Alonso Villaseñor AS; Facultad Mexicana de Medicina, Universidad La Salle, Mexico City, Mexico., Argueta Muñoz FD; Centro de Simulación Clínica y Laboratorios, Universidad de la Salud, Mexico City, Mexico., Gómez Apo E; Departamento de Neuropatología del Servicio de Anatomía Patológica, Hospital General de México 'Dr. Eduardo Liceaga', México; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico., Salinas-Lara C; Red MEDICI, Carrera de Médico Cirujano, FESI, UNAM, State of Mexico, Mexico; Departamento de Neuropatología, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, México. Electronic address: citlalsalinas69@gmail.com., Sánchez-Garibay C; Red MEDICI, Carrera de Médico Cirujano, FESI, UNAM, State of Mexico, Mexico; Departamento de Neuropatología, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, México. Electronic address: carlos.s.garibay@live.com.mx., Tena Suck ML; Departamento de Neuropatología, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, México. |
| Source: | Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2025 Dec; Vol. 155, pp. 102700. Date of Electronic Publication: 2025 Oct 23. |
| Publication Type: | Journal Article; Observational Study |
| Language: | English |
| Journal Info: | Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 100971555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-281X (Electronic) Linking ISSN: 14729792 NLM ISO Abbreviation: Tuberculosis (Edinb) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Edinburgh, New York : Churchill Livingstone, c2001- |
| MeSH Terms: | Cytokines*/analysis , Cytokines*/immunology , Cytokines*/metabolism , Mycobacterium tuberculosis*/immunology , Mycobacterium tuberculosis*/pathogenicity , Tuberculosis, Central Nervous System*/immunology , Tuberculosis, Central Nervous System*/microbiology , Tuberculosis, Central Nervous System*/diagnosis , Tuberculosis, Central Nervous System*/pathology , Tuberculosis, Central Nervous System*/metabolism , Inflammation Mediators*/metabolism , Brain*/immunology , Brain*/pathology , Brain*/microbiology, Humans ; Cross-Sectional Studies ; Male ; Retrospective Studies ; Female ; Adult ; Middle Aged ; Young Adult ; Severity of Illness Index ; Biopsy ; Adolescent ; Host-Pathogen Interactions ; Aged |
| Abstract: | Competing Interests: Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Introduction: Central nervous system tuberculosis (CNS-TB) is the most lethal form of tuberculosis, characterized by severe clinical manifestations and distinctive histopathological changes. Although several cytokines are implicated in the immune response to Mycobacterium tuberculosis, their relationship with disease severity and histological alterations remains unclear. This study aimed to evaluate the associations between cytokine expression, histopathological changes, and clinical features in patients with CNS-TB. Methods: We conducted a retrospective, observational, cross-sectional, descriptive study of 25 biopsies that fulfilled criteria for CNS-TB at the National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez." Cases were classified according to the Suzaan Marais criteria. Immunohistochemistry was performed to assess IL-1β, IL-4, IL-10, IL-17, IL-23, TNF-α, and IFN-γ expression in meningeal and parenchymal tissues. Results: Strong expression of IL-1β, IL-17, IL-23, and TNF-α was observed in glial cells, vascular endothelial cells, and macrophages, particularly within inflammatory and vascular lesions. Conclusions: Although no direct correlation was found between cytokine expression and clinical severity, the findings support a predominant pro-inflammatory response mediated by IL-1β, IL-17, IL-23, and TNF-α, associated with tissue and vascular damage. The elevated cytokine expression in foam cells suggests a potential role in local immune regulation in CNS-TB. (Copyright © 2025 Elsevier Ltd. All rights reserved.) |
| Contributed Indexing: | Keywords: Central nervous system tuberculosis; Cytokines; Foam cells; Vascular disturbances |
| Substance Nomenclature: | 0 (Cytokines) 0 (Inflammation Mediators) |
| Entry Date(s): | Date Created: 20251028 Date Completed: 20251202 Latest Revision: 20251202 |
| Update Code: | 20251203 |
| DOI: | 10.1016/j.tube.2025.102700 |
| PMID: | 41151465 |
| Database: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstract: | Competing Interests: Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br />Introduction: Central nervous system tuberculosis (CNS-TB) is the most lethal form of tuberculosis, characterized by severe clinical manifestations and distinctive histopathological changes. Although several cytokines are implicated in the immune response to Mycobacterium tuberculosis, their relationship with disease severity and histological alterations remains unclear. This study aimed to evaluate the associations between cytokine expression, histopathological changes, and clinical features in patients with CNS-TB.<br />Methods: We conducted a retrospective, observational, cross-sectional, descriptive study of 25 biopsies that fulfilled criteria for CNS-TB at the National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez." Cases were classified according to the Suzaan Marais criteria. Immunohistochemistry was performed to assess IL-1β, IL-4, IL-10, IL-17, IL-23, TNF-α, and IFN-γ expression in meningeal and parenchymal tissues.<br />Results: Strong expression of IL-1β, IL-17, IL-23, and TNF-α was observed in glial cells, vascular endothelial cells, and macrophages, particularly within inflammatory and vascular lesions.<br />Conclusions: Although no direct correlation was found between cytokine expression and clinical severity, the findings support a predominant pro-inflammatory response mediated by IL-1β, IL-17, IL-23, and TNF-α, associated with tissue and vascular damage. The elevated cytokine expression in foam cells suggests a potential role in local immune regulation in CNS-TB.<br /> (Copyright © 2025 Elsevier Ltd. All rights reserved.) |
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| ISSN: | 1873-281X |
| DOI: | 10.1016/j.tube.2025.102700 |