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Bush medicine of the Mbabaram Aboriginal community in Far North Queensland demonstrates strong antioxidant and anti-inflammatory activities.

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Titel: Bush medicine of the Mbabaram Aboriginal community in Far North Queensland demonstrates strong antioxidant and anti-inflammatory activities.
Autoren: Turpin G; Australian Tropical Herbarium (ATH), James Cook University, Nguma Bada Campus, McGregor Road, Smithfield, QLD, 4878, Australia.; Queensland Herbarium and Biodiversity Science, Department of the Environment, Tourism, Science and Innovation (DETSI), Brisbane Botanic Gardens, Mount Coot-tha, Mount Cooth-Tha Road, Toowong, QLD, 4066, Australia.; College of Science and Engineering (CSE), James Cook University, McGregor Rd, Smithfield, Cairns, QLD, 4878, Australia.; Australian Institute of Tropical Health and Medicine (AITHM), James Cook University, McGregor Rd, Smithfield, Cairns, QLD, 4878, Australia.; ARC Centre of Excellence for Indigenous and Environmental Histories and Futures, James Cook University, Nguma-Bada Campus, McGregor Rd, Smithfield, Cairns, QLD, 4878, Australia., Yeshi K; College of Science and Engineering (CSE), James Cook University, McGregor Rd, Smithfield, Cairns, QLD, 4878, Australia.; Australian Institute of Tropical Health and Medicine (AITHM), James Cook University, McGregor Rd, Smithfield, Cairns, QLD, 4878, Australia., Crayn D; Australian Tropical Herbarium (ATH), James Cook University, Nguma Bada Campus, McGregor Road, Smithfield, QLD, 4878, Australia.; Queensland Herbarium and Biodiversity Science, Department of the Environment, Tourism, Science and Innovation (DETSI), Brisbane Botanic Gardens, Mount Coot-tha, Mount Cooth-Tha Road, Toowong, QLD, 4066, Australia.; ARC Centre of Excellence for Indigenous and Environmental Histories and Futures, James Cook University, Nguma-Bada Campus, McGregor Rd, Smithfield, Cairns, QLD, 4878, Australia.; Australian National Herbarium, Commonwealth Industrial and Scientific Research Organisation (CSIRO), Clunies Ross Street, ACT, Canberra, 2601, Australia., Guivarra K; Mbabaram Aboriginal Corporation (MAC), Shop 3, 30 Mabel Street, Atherton, QLD, 4883, Australia., Turpin V; Mbabaram Aboriginal Corporation (MAC), Shop 3, 30 Mabel Street, Atherton, QLD, 4883, Australia., Motlap S; Mbabaram Aboriginal Corporation (MAC), Shop 3, 30 Mabel Street, Atherton, QLD, 4883, Australia., Wangchuk P; College of Science and Engineering (CSE), James Cook University, McGregor Rd, Smithfield, Cairns, QLD, 4878, Australia. phurpa.wangchuk@jcu.edu.au.; Australian Institute of Tropical Health and Medicine (AITHM), James Cook University, McGregor Rd, Smithfield, Cairns, QLD, 4878, Australia. phurpa.wangchuk@jcu.edu.au.
Quelle: BMC complementary medicine and therapies [BMC Complement Med Ther] 2025 Oct 24; Vol. 25 (1), pp. 398. Date of Electronic Publication: 2025 Oct 24.
Publikationsart: Journal Article
Sprache: English
Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101761232 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-7671 (Electronic) Linking ISSN: 26627671 NLM ISO Abbreviation: BMC Complement Med Ther Subsets: MEDLINE
Imprint Name(s): Original Publication: London : BioMed Central, [2020]-
MeSH-Schlagworte: Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Antioxidants*/pharmacology , Antioxidants*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Plants, Medicinal*/chemistry, Humans ; Queensland ; Medicine, Traditional ; Leukocytes, Mononuclear/drug effects ; Ethnobotany
Abstract: Competing Interests: Declarations. Ethics approval and consent to participate: The human ethics approval (H8072) and the plant collection permits (BIBC20200417-2) were obtained from James Cook University Ethics Committee and the Department of Environment and Science, Queensland government, respectively. Informed consent was given by Mbabaram Aboriginal Community as per the human ethics approval (H8072). Competing interests: The authors declare no competing interests.
Introduction: The Mbabaram Aboriginal community lives in Atherton Tableland of Far North Queensland, Australia. While most of the knowledge had been lost due to colonial influences, this community still has remnants of traditional biocultural knowledge, which is critically endangered. They have been closely working with the Tropical Indigenous Ethnobotany Centre (Queensland Herbarium, James Cook University) in the areas of documenting traditional biocultural knowledge and biodiscovery projects. The current study investigated five medicinal plants used by the Mbabaram Aboriginal community for treating wounds, and inflammation-associated diseases.
Methods: In this study, crude extracts of five medicinal plants from the Mbabaram community (Breynia oblongifolia, Cajanus reticulatus, Dodonaea lanceolata, Exocarpos latifolius, and Coleus amoenus) were assessed for their phytochemical contents. The antioxidant activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Furthermore, crude extracts were evaluated for their effect on cell viability and anti-inflammatory activities using the human peripheral blood mononuclear cells (PBMC) assay.
Results: While some plants tested positive for flavonoids and saponins, B. oblongifolia and C. amoenus did not test positive for saponins. Only C. reticulatus and E. latifolius tested positive for alkaloids. The water extract of C. amoenus and the ethanol extract of B. oblongifolia exhibited the highest TPC with 99.88 ± 4.47 GAE/g extract and 128.36 ± 14.09 GAE/g extract, respectively. While the crude water extract of E. latifolius stems showed the best antioxidant activity with EC 50 value of 0.024 μg/mL, the water extract of B. oblongifolia leaf showed the best anti-inflammatory activity by significantly reducing the levels of four pro-inflammatory cytokines, namely IL-1β, IL-6, IL-8, and TNF, which are known for instigating IBD pathogenesis.
Conclusions: Of the five aqueous crude extracts studied here, E. latifolius stems showed the best antioxidant activity and B. oblongifolia leaf showed the best anti-inflammatory activity. This result validated the traditional uses of medicinal plants, which is used for treating inflammation-related conditions including wounds and sores. B. oblongifolia has potential to yield drug lead molecules for developing treatment for inflammation and sores/ulcers related diseases such as IBD.
(© 2025. The Author(s).)
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Grant Information: APP1183323 National Health and Medical Research Council; APP1183323 National Health and Medical Research Council; APP1183323 National Health and Medical Research Council; APP1183323 National Health and Medical Research Council; APP1183323 National Health and Medical Research Council
Contributed Indexing: Keywords: Anti-inflammatory; Anti-oxidant; Australia; Mbabaram Aboriginal Community; Medicinal plants; Phytochemicals; Queensland
Substance Nomenclature: 0 (Anti-Inflammatory Agents)
0 (Antioxidants)
0 (Plant Extracts)
Entry Date(s): Date Created: 20251024 Date Completed: 20251025 Latest Revision: 20251027
Update Code: 20251027
PubMed Central ID: PMC12551138
DOI: 10.1186/s12906-025-05042-2
PMID: 41136979
Datenbank: MEDLINE
Beschreibung
Abstract:Competing Interests: Declarations. Ethics approval and consent to participate: The human ethics approval (H8072) and the plant collection permits (BIBC20200417-2) were obtained from James Cook University Ethics Committee and the Department of Environment and Science, Queensland government, respectively. Informed consent was given by Mbabaram Aboriginal Community as per the human ethics approval (H8072). Competing interests: The authors declare no competing interests.<br />Introduction: The Mbabaram Aboriginal community lives in Atherton Tableland of Far North Queensland, Australia. While most of the knowledge had been lost due to colonial influences, this community still has remnants of traditional biocultural knowledge, which is critically endangered. They have been closely working with the Tropical Indigenous Ethnobotany Centre (Queensland Herbarium, James Cook University) in the areas of documenting traditional biocultural knowledge and biodiscovery projects. The current study investigated five medicinal plants used by the Mbabaram Aboriginal community for treating wounds, and inflammation-associated diseases.<br />Methods: In this study, crude extracts of five medicinal plants from the Mbabaram community (Breynia oblongifolia, Cajanus reticulatus, Dodonaea lanceolata, Exocarpos latifolius, and Coleus amoenus) were assessed for their phytochemical contents. The antioxidant activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Furthermore, crude extracts were evaluated for their effect on cell viability and anti-inflammatory activities using the human peripheral blood mononuclear cells (PBMC) assay.<br />Results: While some plants tested positive for flavonoids and saponins, B. oblongifolia and C. amoenus did not test positive for saponins. Only C. reticulatus and E. latifolius tested positive for alkaloids. The water extract of C. amoenus and the ethanol extract of B. oblongifolia exhibited the highest TPC with 99.88 ± 4.47 GAE/g extract and 128.36 ± 14.09 GAE/g extract, respectively. While the crude water extract of E. latifolius stems showed the best antioxidant activity with EC <subscript>50</subscript> value of 0.024 μg/mL, the water extract of B. oblongifolia leaf showed the best anti-inflammatory activity by significantly reducing the levels of four pro-inflammatory cytokines, namely IL-1β, IL-6, IL-8, and TNF, which are known for instigating IBD pathogenesis.<br />Conclusions: Of the five aqueous crude extracts studied here, E. latifolius stems showed the best antioxidant activity and B. oblongifolia leaf showed the best anti-inflammatory activity. This result validated the traditional uses of medicinal plants, which is used for treating inflammation-related conditions including wounds and sores. B. oblongifolia has potential to yield drug lead molecules for developing treatment for inflammation and sores/ulcers related diseases such as IBD.<br /> (© 2025. The Author(s).)
ISSN:2662-7671
DOI:10.1186/s12906-025-05042-2