New estimation of S-coefficients for radionuclides C-11, N-13, O-15, and F-18 in male and female computational mesh-type phantom using DoseCalcs code.
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| Název: | New estimation of S-coefficients for radionuclides C-11, N-13, O-15, and F-18 in male and female computational mesh-type phantom using DoseCalcs code. |
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| Autoři: | El Ghalbzouri T; ERSN Laboratory, Department of Physics, Faculty of Sciences, University Abdelmalek Essaadi, Tetouan, Morocco. telghalbzouri@uae.ac.ma., Yerrou R; ERSN Laboratory, Department of Physics, Faculty of Sciences, University Abdelmalek Essaadi, Tetouan, Morocco., El Bakkali J; ERSN Laboratory, Department of Physics, Faculty of Sciences, University Abdelmalek Essaadi, Tetouan, Morocco.; Royal School of Military Health Service, Rabat, Morocco., El Bardouni T; ERSN Laboratory, Department of Physics, Faculty of Sciences, University Abdelmalek Essaadi, Tetouan, Morocco. |
| Zdroj: | Radiological physics and technology [Radiol Phys Technol] 2025 Oct 18. Date of Electronic Publication: 2025 Oct 18. |
| Publication Model: | Ahead of Print |
| Způsob vydávání: | Journal Article |
| Jazyk: | English |
| Informace o časopise: | Publisher: Springer Japan Country of Publication: Japan NLM ID: 101467995 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-0341 (Electronic) Linking ISSN: 18650333 NLM ISO Abbreviation: Radiol Phys Technol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Tokyo : Springer Japan |
| Abstrakt: | Accurate estimation of absorbed doses in organs/tissues is essential for effective internal dosimetry. This is especially the case for positron-emission tomography-utilized radiopharmaceuticals that contain positron-emitting radionuclides. To achieve this, it is essential to calculate S-coefficients (S), basic coefficients representing the absorbed dose in the target organ per unit of nuclear transformation in the source organ. In addition, as the evolution of computational phantoms from stylized, voxelized, to mesh-type models continues, updating the S-coefficients to correspond with the new phantom generation becomes required. We employed the DoseCalcs Monte Carlo platform to estimate S-coefficients for four positron-emitting radionuclides, namely, C-11, N-13, O-15, and F-18. Based on decay and energy data for emitted positrons that were obtained from ICRP Publication 107, the simulations involved 24 regions as internal radiation sources in the male and female mesh-type phantoms of the International Commission on Radiological Protection (ICRP). We calculated the S-coefficients for 25 radiosensitive target regions. The graphs of S-coefficients for all target INLINEMATH source pairs exhibit similar trends for the four radionuclides. We compared the results with the OpenDose database, which calculated S-coefficients for voxelized phantoms. The comparison showed that the S-coefficients and the OpenDose voxelized values were very close for most target regions in the mesh-type phantoms. However, discrepancies were observed in specific cases, such as thyroid INLINEMATH UBCs and liver INLINEMATH HeW. These discrepancies arise primarily from the differences in organs/tissues locations and shapes, as well as the differences in material composition, which is distributed across the large inter-distance between the source and target, contributing to significant variations. (© 2025. The Author(s), under exclusive licence to Japanese Society of Radiological Technology and Japan Society of Medical Physics.) |
| Competing Interests: | Declarations. Conflict of interest: The authors declare that they have no conflict of interest. Ethical approval: This research does not involve human participants and animals. |
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| Contributed Indexing: | Keywords: DoseCalcs; Geant4; Internal dosimetry; Mesh-type phantom; Monte Carlo; Positron-emitting radionuclide; S-coefficient |
| Entry Date(s): | Date Created: 20251018 Latest Revision: 20251018 |
| Update Code: | 20251018 |
| DOI: | 10.1007/s12194-025-00978-z |
| PMID: | 41108355 |
| Databáze: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Accurate estimation of absorbed doses in organs/tissues is essential for effective internal dosimetry. This is especially the case for positron-emission tomography-utilized radiopharmaceuticals that contain positron-emitting radionuclides. To achieve this, it is essential to calculate S-coefficients (S), basic coefficients representing the absorbed dose in the target organ per unit of nuclear transformation in the source organ. In addition, as the evolution of computational phantoms from stylized, voxelized, to mesh-type models continues, updating the S-coefficients to correspond with the new phantom generation becomes required. We employed the DoseCalcs Monte Carlo platform to estimate S-coefficients for four positron-emitting radionuclides, namely, C-11, N-13, O-15, and F-18. Based on decay and energy data for emitted positrons that were obtained from ICRP Publication 107, the simulations involved 24 regions as internal radiation sources in the male and female mesh-type phantoms of the International Commission on Radiological Protection (ICRP). We calculated the S-coefficients for 25 radiosensitive target regions. The graphs of S-coefficients for all target INLINEMATH source pairs exhibit similar trends for the four radionuclides. We compared the results with the OpenDose database, which calculated S-coefficients for voxelized phantoms. The comparison showed that the S-coefficients and the OpenDose voxelized values were very close for most target regions in the mesh-type phantoms. However, discrepancies were observed in specific cases, such as thyroid INLINEMATH UBCs and liver INLINEMATH HeW. These discrepancies arise primarily from the differences in organs/tissues locations and shapes, as well as the differences in material composition, which is distributed across the large inter-distance between the source and target, contributing to significant variations.<br /> (© 2025. The Author(s), under exclusive licence to Japanese Society of Radiological Technology and Japan Society of Medical Physics.) |
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| ISSN: | 1865-0341 |
| DOI: | 10.1007/s12194-025-00978-z |