The association between retinal artery to vein ratio and fat distribution: a population-based cross-sectional study.
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| Názov: | The association between retinal artery to vein ratio and fat distribution: a population-based cross-sectional study. |
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| Autori: | Zhao Y; Department of Ophthalmology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital，Hangzhou Medical College, Hangzhou, Zhejiang, China., Huang D; Binjiang Institute of Zhejiang University, Hangzhou, Zhejiang, China., Jin H; The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, China., Dong Y; Department of Ophthalmology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital，Hangzhou Medical College, Hangzhou, Zhejiang, China., Shan J; The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, China., Zhang D; Jinzhou Medical University, Jinzhou, 121002, China., Qiu P; Eye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, No.1 West Lake Avenue, Hangzhou, Zhejiang, 310009, China., Hong C; Department of Ophthalmology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital，Hangzhou Medical College, Hangzhou, Zhejiang, China., Shen T; Department of Ophthalmology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital，Hangzhou Medical College, Hangzhou, Zhejiang, China. medicat@zju.edu.cn.; Eye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, No.1 West Lake Avenue, Hangzhou, Zhejiang, 310009, China. medicat@zju.edu.cn. |
| Zdroj: | BMC ophthalmology [BMC Ophthalmol] 2025 Oct 14; Vol. 25 (1), pp. 566. Date of Electronic Publication: 2025 Oct 14. |
| Spôsob vydávania: | Journal Article |
| Jazyk: | English |
| Informácie o časopise: | Publisher: BioMed Central Country of Publication: England NLM ID: 100967802 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2415 (Electronic) Linking ISSN: 14712415 NLM ISO Abbreviation: BMC Ophthalmol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2001- |
| Výrazy zo slovníka MeSH: | Body Fat Distribution* , Retinal Vein*/diagnostic imaging , Retinal Artery*/diagnostic imaging, Humans ; Middle Aged ; Female ; Adult ; Cross-Sectional Studies ; Male ; Aged ; Young Adult ; Aged, 80 and over ; Adolescent ; Absorptiometry, Photon ; Adipose Tissue ; Waist-Hip Ratio |
| Abstrakt: | Competing Interests: Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of the School of Public Health of Zhejiang University, and informed consent was obtained from all participant. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Objective: This study aims to investigate the association between the retinal artery to vein ratio (AVR) and body fat distribution, and to further evaluate the potential beneficial effects of optimized fat distribution on systemic vascular health. Methods: A total of 2,698 participants aged 18 to 80 from Lanxi cohort were enrolled. After applying inclusion and exclusion criteria, 2,045 participants were retained for the final analysis. Retinal vessel images were obtained through fundoscopy, and retinal AVR was automatically calculated using a clinically validated AI algorithm. Body fat was assessed by dual-energy x-ray absorptiometry (DXA). Adjusted multivariate linear regression models were used to identify the associations of retinal AVR with fat distribution. Results: Retinal AVR was negatively associated with waist-hip ratio (WHR), android fat mass percentage, android to gynoid fat ratio, and trunk fat mass percentage. Similar trends were observed when fat distribution indicators were categorized into quartiles (P for trend < 0.05). When stratified by age, a similar significant association was observed in the 45-60 age group. Conclusions: Retinal AVR was associated with fat distribution, with particularly correlations observed in middle-aged populations and those with metabolic abnormalities. And these associations differ based on the location of fat depots, indicating that exercise-induced fat redistribution is associated with vascular health. (© 2025. The Author(s).) |
| References: | J Clin Res Pediatr Endocrinol. 2014 Dec;6(4):227-32. (PMID: 25541893) IEEE Trans Med Imaging. 2019 Oct;38(10):2281-2292. (PMID: 30843824) Sci Rep. 2017 Sep 8;7(1):10955. (PMID: 28887474) Prog Retin Eye Res. 2014 Sep;42:44-84. (PMID: 24984227) Prog Cardiovasc Dis. 2018 Jul - Aug;61(2):151-156. (PMID: 29852198) Atherosclerosis. 2006 Nov;189(1):47-60. (PMID: 16580676) J Clin Endocrinol Metab. 2025 Jan 21;110(2):e372-e381. (PMID: 38529938) Science. 1993 Jan 1;259(5091):87-91. (PMID: 7678183) Lancet. 2001 Oct 6;358(9288):1134-40. (PMID: 11597667) Lancet Diabetes Endocrinol. 2015 Jun;3(6):437-449. (PMID: 25960160) Curr Pharm Des. 2010 Jun;16(17):1896-901. (PMID: 20370675) Metabolism. 1991 Dec;40(12):1323-6. (PMID: 1961129) Circulation. 2012 Sep 4;126(10):1301-13. (PMID: 22949540) Am J Epidemiol. 1995 Jun 15;141(12):1117-27. (PMID: 7771450) Invest Ophthalmol Vis Sci. 2015 Jan 08;56(2):705-10. (PMID: 25574054) Eat Weight Disord. 2021 Feb;26(1):27-35. (PMID: 31865598) Microcirculation. 2013 Oct;20(7):609-16. (PMID: 23517335) J Clin Endocrinol Metab. 2005 Mar;90(3):1434-9. (PMID: 15598678) Obes Facts. 2017;10(3):207-215. (PMID: 28564650) Hypertension. 2004 Oct;44(4):442-7. (PMID: 15302843) JPEN J Parenter Enteral Nutr. 2008 Nov-Dec;32(6):638-44. (PMID: 18974244) Clin Endocrinol (Oxf). 2015 Mar;82(3):377-87. (PMID: 24974911) Microcirculation. 2017 Nov;24(8):. (PMID: 28926162) N Engl J Med. 2017 Jul 6;377(1):13-27. (PMID: 28604169) J Obes Metab Syndr. 2017 Sep;26(3):172-180. (PMID: 31089514) Prog Retin Eye Res. 2022 Nov;91:101095. (PMID: 35760749) Med Sci Sports Exerc. 2003 Aug;35(8):1381-95. (PMID: 12900694) Lancet Diabetes Endocrinol. 2013 Oct;1(2):152-62. (PMID: 24622321) J Hypertens. 2024 Jun 1;42(6):1039-1047. (PMID: 38415366) Nat Rev Mol Cell Biol. 2019 Apr;20(4):242-258. (PMID: 30610207) Circ Res. 2020 May 22;126(11):1477-1500. (PMID: 32437302) Cell Metab. 2025 Mar 04;37(3):640-655.e4. (PMID: 39694039) Obesity (Silver Spring). 2015 Jul;23(7):1345-52. (PMID: 26054752) Biomed Res Int. 2014;2014:757461. (PMID: 24734243) Rev Endocr Metab Disord. 2022 Feb;23(1):5-12. (PMID: 34935088) Biomedicines. 2024 Sep 23;12(9):. (PMID: 39335664) Hypertens Res. 2016 Jun;39(6):423-9. (PMID: 26763853) Nutr Diabetes. 2013 Sep 30;3:e90. (PMID: 24080943) Int J Obes (Lond). 2014 Jan;38(1):69-75. (PMID: 23779050) Clin Exp Ophthalmol. 2018 Jul;46(5):531-552. (PMID: 29193621) Obesity (Silver Spring). 2018 Oct;26(10):1637-1643. (PMID: 30260089) Transl Vis Sci Technol. 2024 Nov 4;13(11):26. (PMID: 39570618) Lancet. 2014 Mar 15;383(9921):970-83. (PMID: 24269108) Osteoporos Int. 2011 Jan;22(1):113-9. (PMID: 20306018) AMIA Jt Summits Transl Sci Proc. 2018 May 18;2017:147-155. (PMID: 29888061) Curr Eye Res. 2023 Sep;48(9):843-849. (PMID: 37246501) Obesity (Silver Spring). 2020 Sep;28(9):1750-1760. (PMID: 32725961) Obes Rev. 2012 Mar;13(3):275-86. (PMID: 22106927) J Clin Invest. 2020 Nov 2;130(11):5688-5702. (PMID: 32701509) Prog Cardiovasc Dis. 2023 May-Jun;78:2-10. (PMID: 36481212) JAMA. 2002 Mar 6;287(9):1153-9. (PMID: 11879113) Expert Rev Cardiovasc Ther. 2008 Mar;6(3):343-68. (PMID: 18327995) J Digit Imaging. 2021 Jun;34(3):750-759. (PMID: 33885992) Int J Obes (Lond). 2015 Oct;39(10):1482-7. (PMID: 26028060) Nat Med. 2003 Jun;9(6):653-60. (PMID: 12778163) |
| Grant Information: | NO.2023C03089 Research and Development Plan of Zhejiang Science and Technology Department; No.2021C03103 Provincial key research and development plan of Zhejiang science and technology program; No.2025JK023 Zhejiang Science and Technology Plan for Disease Prevention and Control |
| Contributed Indexing: | Keywords: Android fat; DXA; Fat distribution; Retinal artery to vein ratio |
| Entry Date(s): | Date Created: 20251014 Date Completed: 20251015 Latest Revision: 20251017 |
| Update Code: | 20251017 |
| PubMed Central ID: | PMC12523189 |
| DOI: | 10.1186/s12886-025-04408-x |
| PMID: | 41087991 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Competing Interests: Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of the School of Public Health of Zhejiang University, and informed consent was obtained from all participant. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.<br />Objective: This study aims to investigate the association between the retinal artery to vein ratio (AVR) and body fat distribution, and to further evaluate the potential beneficial effects of optimized fat distribution on systemic vascular health.<br />Methods: A total of 2,698 participants aged 18 to 80 from Lanxi cohort were enrolled. After applying inclusion and exclusion criteria, 2,045 participants were retained for the final analysis. Retinal vessel images were obtained through fundoscopy, and retinal AVR was automatically calculated using a clinically validated AI algorithm. Body fat was assessed by dual-energy x-ray absorptiometry (DXA). Adjusted multivariate linear regression models were used to identify the associations of retinal AVR with fat distribution.<br />Results: Retinal AVR was negatively associated with waist-hip ratio (WHR), android fat mass percentage, android to gynoid fat ratio, and trunk fat mass percentage. Similar trends were observed when fat distribution indicators were categorized into quartiles (P for trend < 0.05). When stratified by age, a similar significant association was observed in the 45-60 age group.<br />Conclusions: Retinal AVR was associated with fat distribution, with particularly correlations observed in middle-aged populations and those with metabolic abnormalities. And these associations differ based on the location of fat depots, indicating that exercise-induced fat redistribution is associated with vascular health.<br /> (© 2025. The Author(s).) |
|---|---|
| ISSN: | 1471-2415 |
| DOI: | 10.1186/s12886-025-04408-x |