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Recent Developments in Borrowing Hydrogen Methodology in N-alkylation of Amines.

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Title: Recent Developments in Borrowing Hydrogen Methodology in N-alkylation of Amines.
Authors: Yadav S; Department of Chemistry, Faculty of Science, University of Lucknow, Lucknow, 226 007, India., Pal D; Department of Chemistry, Faculty of Science, University of Lucknow, Lucknow, 226 007, India., Maurya SK; Department of Chemistry, Faculty of Science, University of Lucknow, Lucknow, 226 007, India. sushilncl@gmail.com.
Source: Topics in current chemistry (Cham) [Top Curr Chem (Cham)] 2025 Oct 09; Vol. 383 (4), pp. 46. Date of Electronic Publication: 2025 Oct 09.
Publication Type: Journal Article; Review
Language: English
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 101691301 Publication Model: Electronic Cited Medium: Internet ISSN: 2364-8961 (Electronic) Linking ISSN: 23648961 NLM ISO Abbreviation: Top Curr Chem (Cham) Subsets: MEDLINE
Imprint Name(s): Original Publication: Cham : Springer, [2016]-
MeSH Terms: Amines*/chemistry , Amines*/chemical synthesis , Hydrogen*/chemistry, Alkylation ; Catalysis ; Molecular Structure
Abstract: In modern organic synthesis, the catalytic borrowing hydrogen methodology has emerged as a transformative strategy for the N-alkylation of amines with water as the only byproduct. Here, we have highlighted the recent developments over the period (approximately) from 2014 to 2024. We have discussed all the emerging catalytic systems, such as the use of non-metallic, homogeneous, heterogeneous, and electrocatalysts using noble and non-noble metals, with an emphasis on advancements that expand reaction scope, improve selectivity, and enhance selectivity. Ultimately, we aim to provide a comprehensive overview of catalytic N-alkylation processes, focusing on sustainable, efficient methodologies for a greener approach.
(© 2025. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
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Contributed Indexing: Keywords: N-alkylation of amines; Borrowing hydrogen methodology; Heterogeneous catalysis; Homogeneous catalysis
Substance Nomenclature: 0 (Amines)
7YNJ3PO35Z (Hydrogen)
Entry Date(s): Date Created: 20251009 Date Completed: 20251009 Latest Revision: 20251204
Update Code: 20251205
DOI: 10.1007/s41061-025-00523-x
PMID: 41066029
Database: MEDLINE
Description
Abstract:In modern organic synthesis, the catalytic borrowing hydrogen methodology has emerged as a transformative strategy for the N-alkylation of amines with water as the only byproduct. Here, we have highlighted the recent developments over the period (approximately) from 2014 to 2024. We have discussed all the emerging catalytic systems, such as the use of non-metallic, homogeneous, heterogeneous, and electrocatalysts using noble and non-noble metals, with an emphasis on advancements that expand reaction scope, improve selectivity, and enhance selectivity. Ultimately, we aim to provide a comprehensive overview of catalytic N-alkylation processes, focusing on sustainable, efficient methodologies for a greener approach.<br /> (© 2025. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
ISSN:2364-8961
DOI:10.1007/s41061-025-00523-x