RNA interference-based therapeutics against aquatic viral diseases: Recent advances in fish and crustaceans (2010-2025).
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| Názov: | RNA interference-based therapeutics against aquatic viral diseases: Recent advances in fish and crustaceans (2010-2025). |
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| Autori: | Zhong C; Marine Science Research Institute of Shandong Province, Qingdao, 266104, China; Municipal Engineering Research Center of Aquatic Biological Quality Evaluation and Application, Qingdao, 266104, China., Jin N; Haide College, Ocean University of China, Qingdao, 266003, China., Liu M; Marine Science Research Institute of Shandong Province, Qingdao, 266104, China; Municipal Engineering Research Center of Aquatic Biological Quality Evaluation and Application, Qingdao, 266104, China., Ye H; Marine Science Research Institute of Shandong Province, Qingdao, 266104, China; Municipal Engineering Research Center of Aquatic Biological Quality Evaluation and Application, Qingdao, 266104, China., Diao J; Marine Science Research Institute of Shandong Province, Qingdao, 266104, China; Municipal Engineering Research Center of Aquatic Biological Quality Evaluation and Application, Qingdao, 266104, China. Electronic address: doro530@sina.com., Wang Y; Marine Science Research Institute of Shandong Province, Qingdao, 266104, China; Municipal Engineering Research Center of Aquatic Biological Quality Evaluation and Application, Qingdao, 266104, China. Electronic address: yzsshipin@126.com. |
| Zdroj: | Fish & shellfish immunology [Fish Shellfish Immunol] 2026 Jan; Vol. 168, pp. 110913. Date of Electronic Publication: 2025 Oct 07. |
| Spôsob vydávania: | Journal Article; Review |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Academic Press Country of Publication: England NLM ID: 9505220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9947 (Electronic) Linking ISSN: 10504648 NLM ISO Abbreviation: Fish Shellfish Immunol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London ; New York : Academic Press, c1991- |
| Výrazy zo slovníka MeSH: | Fish Diseases*/therapy , Fish Diseases*/virology , Fish Diseases*/immunology , RNA Interference* , Virus Diseases*/veterinary , Virus Diseases*/therapy , Crustacea*/virology , RNAi Therapeutics*/veterinary, Animals ; Fishes ; Aquaculture |
| Abstrakt: | Competing Interests: Declaration of competing interest The authors declare no conflict of interest. Viral diseases inflict severe economic losses on global aquaculture, driving the urgent need for sustainable and effective disease management strategies. Conventional chemical treatments are increasingly limited by environmental concerns, antibiotic resistance, and scarcity of specific antivirals. RNA interference (RNAi) has emerged as a pivotal functional genomics tool and a promising antiviral strategy. It utilizes synthetic RNA molecules that are designed to be complementary to viral mRNA sequences. This complementarity allows for the precise targeting and degradation of the viral mRNA, thereby silencing the gene expression. For instance, RNAi has shown significant potential in combating nervous necrosis virus (NNV) in grouper and white spot syndrome virus (WSSV) in penaeid shrimp. However, practical implementation of RNAi-based therapies in aquaculture remains constrained by off-target effects and challenges in achieving safe, efficient in vivo delivery of RNAi molecules. This review summarizes significant RNAi applications against viral diseases in fish and crustaceans (2010-2025), analyzes its strengths and limitations as both a research tool and a therapeutic platform, offering a perspective on innovative delivery strategies and a pathway for future development to bridge the gap between laboratory research and practical application in controlling aquatic viral pathogens. (Copyright © 2025 Elsevier Ltd. All rights reserved.) |
| Contributed Indexing: | Keywords: Antiviral therapy; Aquaculture; Fish and crustacean viruses; Gene silencing; RNA delivery; RNA interference |
| Entry Date(s): | Date Created: 20251008 Date Completed: 20251129 Latest Revision: 20251129 |
| Update Code: | 20251130 |
| DOI: | 10.1016/j.fsi.2025.110913 |
| PMID: | 41062005 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Competing Interests: Declaration of competing interest The authors declare no conflict of interest.<br />Viral diseases inflict severe economic losses on global aquaculture, driving the urgent need for sustainable and effective disease management strategies. Conventional chemical treatments are increasingly limited by environmental concerns, antibiotic resistance, and scarcity of specific antivirals. RNA interference (RNAi) has emerged as a pivotal functional genomics tool and a promising antiviral strategy. It utilizes synthetic RNA molecules that are designed to be complementary to viral mRNA sequences. This complementarity allows for the precise targeting and degradation of the viral mRNA, thereby silencing the gene expression. For instance, RNAi has shown significant potential in combating nervous necrosis virus (NNV) in grouper and white spot syndrome virus (WSSV) in penaeid shrimp. However, practical implementation of RNAi-based therapies in aquaculture remains constrained by off-target effects and challenges in achieving safe, efficient in vivo delivery of RNAi molecules. This review summarizes significant RNAi applications against viral diseases in fish and crustaceans (2010-2025), analyzes its strengths and limitations as both a research tool and a therapeutic platform, offering a perspective on innovative delivery strategies and a pathway for future development to bridge the gap between laboratory research and practical application in controlling aquatic viral pathogens.<br /> (Copyright © 2025 Elsevier Ltd. All rights reserved.) |
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| ISSN: | 1095-9947 |
| DOI: | 10.1016/j.fsi.2025.110913 |