Association of maternal biliary disease with hepatopancreatobiliary morbidity in offspring.
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| Názov: | Association of maternal biliary disease with hepatopancreatobiliary morbidity in offspring. |
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| Autori: | Auger N; University of Montreal Hospital Research Centre, Montreal, Quebec, Canada.; Institut national de santé publique du Québec, Montreal, Quebec, Canada.; Department of Medicine, School of Public Health, University of Montreal, Montreal, Quebec, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada., Magri A; Department of Medicine, McGill University, Montreal, Quebec, Canada., Kang-Auger S; Department of Medicine, McGill University, Montreal, Quebec, Canada., Jutras G; Division of Hepatology, Department of Medicine, University of Montreal Hospital Research Centre, Montreal, Quebec, Canada., Healy-Profitós J; University of Montreal Hospital Research Centre, Montreal, Quebec, Canada.; Institut national de santé publique du Québec, Montreal, Quebec, Canada., Bilodeau-Bertrand M; Institut national de santé publique du Québec, Montreal, Quebec, Canada., Côté-Corriveau G; University of Montreal Hospital Research Centre, Montreal, Quebec, Canada.; Institut national de santé publique du Québec, Montreal, Quebec, Canada.; Department of Pediatrics, Sainte-Justine University Hospital Center, Montreal, Quebec, Canada. |
| Zdroj: | Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2025 Dec; Vol. 81 (6), pp. 1422-1430. Date of Electronic Publication: 2025 Oct 06. |
| Spôsob vydávania: | Journal Article |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Wiley Country of Publication: United States NLM ID: 8211545 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-4801 (Electronic) Linking ISSN: 02772116 NLM ISO Abbreviation: J Pediatr Gastroenterol Nutr Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : [Hoboken, New Jersey] : Wiley Original Publication: [New York, N.Y.] : Raven Press, [c1982- |
| Výrazy zo slovníka MeSH: | Biliary Tract Diseases*/complications , Biliary Tract Diseases*/epidemiology , Pregnancy Complications*/epidemiology , Prenatal Exposure Delayed Effects*/epidemiology , Prenatal Exposure Delayed Effects*/etiology , Liver Diseases*/epidemiology , Liver Diseases*/etiology , Pancreatic Diseases*/epidemiology , Pancreatic Diseases*/etiology , Metabolism, Inborn Errors*/epidemiology , Metabolism, Inborn Errors*/etiology, Humans ; Female ; Retrospective Studies ; Pregnancy ; Male ; Adolescent ; Infant ; Infant, Newborn ; Child ; Quebec/epidemiology ; Child, Preschool ; Adult ; Risk Factors |
| Abstrakt: | Objectives: Maternal biliary disease is common, but the link with offspring hepatopancreatobiliary disease has not been studied. We assessed the association between maternal biliary disease and pediatric hepatopancreatobiliary morbidity. Methods: We conducted a retrospective cohort study of 1,271,864 children born between 2006 and 2022 in Quebec, Canada. The exposure was maternal biliary disease. Offspring outcomes included congenital hepatopancreatobiliary anomalies, inborn errors of metabolism, and hepatopancreatobiliary morbidity between birth and age 17 years. We estimated adjusted risk ratios (RR) and hazard ratios (HR) with 95% confidence intervals (CI) for the association of maternal biliary disease with child outcomes. Results: A total of 95,047 children (7.5%) had mothers with biliary disease. Compared with no exposure, maternal biliary disease was associated with an increased risk of bile duct defects (RR 1.67, 95% CI 1.10-2.52), liver defects (RR 1.47, 95% CI 1.05-2.06), and inborn errors of metabolism (RR 1.41, 95% CI 1.24-1.62) in offspring. Exposed children were more likely to be hospitalized for cholelithiasis, cholecystitis, or cholangitis (HR 2.58, 95% CI 2.14-3.12), acute pancreatitis (HR 1.83, 95% CI 1.38-2.43), and metabolic dysfunction-associated steatotic liver disease (HR 2.71, 95% CI 2.07-3.54). Conclusions: Maternal biliary disease is associated with hepatopancreatobiliary complications in offspring. (© 2025 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.) |
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| Grant Information: | 296785 Fonds de recherche du Québec-Santé; PJT-197772 Canada CAPMC CIHR; PJT-197772 Canada CAPMC CIHR |
| Contributed Indexing: | Keywords: biliary tract diseases; congenital abnormalities; liver diseases; pancreatic diseases |
| Entry Date(s): | Date Created: 20251007 Date Completed: 20251201 Latest Revision: 20251203 |
| Update Code: | 20251203 |
| PubMed Central ID: | PMC12666495 |
| DOI: | 10.1002/jpn3.70219 |
| PMID: | 41053991 |
| Databáza: | MEDLINE |
Nájsť tento článok vo Web of Science | Abstrakt: | Objectives: Maternal biliary disease is common, but the link with offspring hepatopancreatobiliary disease has not been studied. We assessed the association between maternal biliary disease and pediatric hepatopancreatobiliary morbidity.<br />Methods: We conducted a retrospective cohort study of 1,271,864 children born between 2006 and 2022 in Quebec, Canada. The exposure was maternal biliary disease. Offspring outcomes included congenital hepatopancreatobiliary anomalies, inborn errors of metabolism, and hepatopancreatobiliary morbidity between birth and age 17 years. We estimated adjusted risk ratios (RR) and hazard ratios (HR) with 95% confidence intervals (CI) for the association of maternal biliary disease with child outcomes.<br />Results: A total of 95,047 children (7.5%) had mothers with biliary disease. Compared with no exposure, maternal biliary disease was associated with an increased risk of bile duct defects (RR 1.67, 95% CI 1.10-2.52), liver defects (RR 1.47, 95% CI 1.05-2.06), and inborn errors of metabolism (RR 1.41, 95% CI 1.24-1.62) in offspring. Exposed children were more likely to be hospitalized for cholelithiasis, cholecystitis, or cholangitis (HR 2.58, 95% CI 2.14-3.12), acute pancreatitis (HR 1.83, 95% CI 1.38-2.43), and metabolic dysfunction-associated steatotic liver disease (HR 2.71, 95% CI 2.07-3.54).<br />Conclusions: Maternal biliary disease is associated with hepatopancreatobiliary complications in offspring.<br /> (© 2025 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.) |
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| ISSN: | 1536-4801 |
| DOI: | 10.1002/jpn3.70219 |