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Mitochondrial damage-associated molecular patterns (mito-DAMPs): Determinants of hepatopathy progression and therapeutic implications.

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Bibliographic Details
Title: Mitochondrial damage-associated molecular patterns (mito-DAMPs): Determinants of hepatopathy progression and therapeutic implications.
Authors: Luo R; School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China., Yang Y; School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China., Zhang Y; School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China., Xue X; School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China., Guo M; School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China., Li X; School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address: xiaojiaoyang.li@bucm.edu.cn.
Source: Pharmacological research [Pharmacol Res] 2025 Nov; Vol. 221, pp. 107980. Date of Electronic Publication: 2025 Oct 04.
Publication Type: Journal Article; Review
Language: English
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE
Imprint Name(s): Publication: Oct. 2015- : Amsterdam ; Elsevier
Original Publication: London ; San Diego : Academic Press, c1989-
MeSH Terms: Liver Diseases*/metabolism , Liver Diseases*/drug therapy , Liver Diseases*/pathology , Liver Diseases*/immunology , Alarmins*/metabolism , Alarmins*/immunology , Mitochondria*/metabolism , Mitochondria*/pathology, Humans ; Animals ; Disease Progression
Abstract: Competing Interests: Declaration of Competing Interest The authors have declared no conflict of interest.
Liver diseases, as the primary representative disorders of the digestive tract, encompass metabolic dysfunction-associated steatotic liver disease (MASLD), liver fibrosis, and malignant liver or gallbladder cancers and pose a significant health challenge to millions of individuals worldwide. Meanwhile, to make matters worse, the incidence of MASLD, which can progress to end-stage liver disease, has gradually increased in recent years due to shifts in dietary practices and lifestyle choices. In the context of various liver diseases, endogenous danger signals released from damaged or dying cells, known as damage-associated molecular patterns (DAMPs), can be recognized by the innate immune system through pattern recognition receptors. This recognition subsequently leads to the recruitment of immune cells and the activation of an inflammatory cascade. Recently, mitochondria have garnered significant attention as a novel source of DAMPs, namely mito-DAMPs. Under stress conditions, various pro-inflammatory mediators, previously thought to play a crucial role in the pathogenesis of liver disease, are released from mitochondria, including mitochondrial DNA, reactive oxygen species, cytochrome c, adenosine triphosphate, cardiolipin and carbamoyl phosphate synthetase 1. Here, we emphasize the significance of these novel mito-DAMPs in the initiation and progression of various liver diseases and discuss the interplay among these molecules under different pathological environment. Our aim is to explore potential therapeutic targets and strategies in drug development that can be employed to combat liver diseases.
(Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Contributed Indexing: Keywords: Mito-DAMPs; liver diseases; mitochondria; mtDNA
Substance Nomenclature: 0 (Alarmins)
Entry Date(s): Date Created: 20251006 Date Completed: 20251103 Latest Revision: 20251107
Update Code: 20251107
DOI: 10.1016/j.phrs.2025.107980
PMID: 41052585
Database: MEDLINE
Description
Abstract:Competing Interests: Declaration of Competing Interest The authors have declared no conflict of interest.<br />Liver diseases, as the primary representative disorders of the digestive tract, encompass metabolic dysfunction-associated steatotic liver disease (MASLD), liver fibrosis, and malignant liver or gallbladder cancers and pose a significant health challenge to millions of individuals worldwide. Meanwhile, to make matters worse, the incidence of MASLD, which can progress to end-stage liver disease, has gradually increased in recent years due to shifts in dietary practices and lifestyle choices. In the context of various liver diseases, endogenous danger signals released from damaged or dying cells, known as damage-associated molecular patterns (DAMPs), can be recognized by the innate immune system through pattern recognition receptors. This recognition subsequently leads to the recruitment of immune cells and the activation of an inflammatory cascade. Recently, mitochondria have garnered significant attention as a novel source of DAMPs, namely mito-DAMPs. Under stress conditions, various pro-inflammatory mediators, previously thought to play a crucial role in the pathogenesis of liver disease, are released from mitochondria, including mitochondrial DNA, reactive oxygen species, cytochrome c, adenosine triphosphate, cardiolipin and carbamoyl phosphate synthetase 1. Here, we emphasize the significance of these novel mito-DAMPs in the initiation and progression of various liver diseases and discuss the interplay among these molecules under different pathological environment. Our aim is to explore potential therapeutic targets and strategies in drug development that can be employed to combat liver diseases.<br /> (Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.)
ISSN:1096-1186
DOI:10.1016/j.phrs.2025.107980