Antibody Level against Hepatitis B Virus in Term and Preterm Infants Following Three Doses of Pentavalent Vaccine as per EPI Schedule.
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| Název: | Antibody Level against Hepatitis B Virus in Term and Preterm Infants Following Three Doses of Pentavalent Vaccine as per EPI Schedule. |
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| Autoři: | Kar N; Dr Nondita Kar, Registrar (Paediatrics), Department of Paediatrics, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh; E-mail: nondita33@gmail.com., Hossain MA, Islam MN, Adhikary PD, Saha BK, Chowdhury B, Mazumder M, Fahmin F, Banik BK, Akhter H, Adhikary DD, Tazmin T |
| Zdroj: | Mymensingh medical journal : MMJ [Mymensingh Med J] 2025 Oct; Vol. 34 (4), pp. 1030-1035. |
| Způsob vydávání: | Journal Article |
| Jazyk: | English |
| Informace o časopise: | Publisher: Mymensingh Medical College Country of Publication: Bangladesh NLM ID: 9601799 Publication Model: Print Cited Medium: Internet ISSN: 2408-8757 (Electronic) Linking ISSN: 10224742 NLM ISO Abbreviation: Mymensingh Med J Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Mymensingh, Bangladesh : Mymensingh Medical College, |
| Výrazy ze slovníku MeSH: | Infant, Premature*/immunology , Hepatitis B Vaccines*/administration & dosage , Hepatitis B Vaccines*/immunology , Immunization Schedule* , Diphtheria-Tetanus-Pertussis Vaccine*/administration & dosage , Hepatitis B Antibodies*/blood , Haemophilus Vaccines*/administration & dosage , Hepatitis B*/prevention & control , Hepatitis B virus*/immunology, Humans ; Infant, Newborn ; Cross-Sectional Studies ; Female ; Male ; Vaccines, Combined/administration & dosage ; Bangladesh ; Infant ; Poliovirus Vaccine, Inactivated |
| Abstrakt: | Childhood acquisition of Hepatitis B infection significantly increases the risk of chronic liver disease. To prevent this, the World Health Organization (WHO) recommends immunizing infants with three doses of the pentavalent vaccine (DPT + Hib + Hepatitis B) at 6, 10 and 14 weeks of age as part of the Expanded Program on Immunization (EPI). Vaccination schedules may vary based on birth weight and maternal Hepatitis B infection status. Preterm infants, due to their potentially weaker immune status, may require revaccination or booster doses in cases of non-response or poor response. This cross-sectional comparative study was conducted in the Department of Pediatrics, Mymensingh Medical College Hospital, Bangladesh, from October 2017 to September 2019. A total of 118 infants (59 terms and 59 preterm) who had completed the three-dose pentavalent vaccine schedule were included, selected from two EPI centers in Mymensingh city. Anti-HBs antibody levels were assessed six weeks after the third vaccine dose using an ELISA immunoassay kit. The mean anti-HBs levels in preterm and term infants were 143.41±37.81 mIU/mL and 140.96±42.81 mIU/mL, respectively, with no statistically significant difference (p>0.05). A good response (anti-HBs >100 mIU/mL) was observed in 89.8% (53/59) of preterm and 86.4% (52/59) of term infants. Poor responses (anti-HBs 10-100 mIU/mL) were seen in 6.8% (4/59) of preterm and 11.9% (7/59) of term infants. Among infants with a birth weight ≥2500 gm, 87.7% (50/57) showed a good response. Infants weighing 1500-2499 g demonstrated a good response in 88.3% (53/60) of cases. Of the 53 preterm good responders, 86.8% (46) had a gestational age of ≥34 weeks at delivery. In conclusion, the current pentavalent vaccine schedule under EPI produces a good immune response in most infants, with no significant difference between term and preterm infants. Among preterm infants, a better immune response was associated with a gestational age of ≥34 weeks. |
| Substance Nomenclature: | 0 (Hepatitis B Vaccines) 0 (Vaccines, Combined) 0 (Diphtheria-Tetanus-Pertussis Vaccine) 0 (Hepatitis B Antibodies) 0 (Pentavac) 0 (Haemophilus Vaccines) 0 (Poliovirus Vaccine, Inactivated) |
| Entry Date(s): | Date Created: 20250930 Date Completed: 20250930 Latest Revision: 20250930 |
| Update Code: | 20250930 |
| PMID: | 41024538 |
| Databáze: | MEDLINE |
Nájsť tento článok vo Web of Science | Abstrakt: | Childhood acquisition of Hepatitis B infection significantly increases the risk of chronic liver disease. To prevent this, the World Health Organization (WHO) recommends immunizing infants with three doses of the pentavalent vaccine (DPT + Hib + Hepatitis B) at 6, 10 and 14 weeks of age as part of the Expanded Program on Immunization (EPI). Vaccination schedules may vary based on birth weight and maternal Hepatitis B infection status. Preterm infants, due to their potentially weaker immune status, may require revaccination or booster doses in cases of non-response or poor response. This cross-sectional comparative study was conducted in the Department of Pediatrics, Mymensingh Medical College Hospital, Bangladesh, from October 2017 to September 2019. A total of 118 infants (59 terms and 59 preterm) who had completed the three-dose pentavalent vaccine schedule were included, selected from two EPI centers in Mymensingh city. Anti-HBs antibody levels were assessed six weeks after the third vaccine dose using an ELISA immunoassay kit. The mean anti-HBs levels in preterm and term infants were 143.41±37.81 mIU/mL and 140.96±42.81 mIU/mL, respectively, with no statistically significant difference (p>0.05). A good response (anti-HBs >100 mIU/mL) was observed in 89.8% (53/59) of preterm and 86.4% (52/59) of term infants. Poor responses (anti-HBs 10-100 mIU/mL) were seen in 6.8% (4/59) of preterm and 11.9% (7/59) of term infants. Among infants with a birth weight ≥2500 gm, 87.7% (50/57) showed a good response. Infants weighing 1500-2499 g demonstrated a good response in 88.3% (53/60) of cases. Of the 53 preterm good responders, 86.8% (46) had a gestational age of ≥34 weeks at delivery. In conclusion, the current pentavalent vaccine schedule under EPI produces a good immune response in most infants, with no significant difference between term and preterm infants. Among preterm infants, a better immune response was associated with a gestational age of ≥34 weeks. |
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| ISSN: | 2408-8757 |