Impact of the Genius Digital Diagnostics System on workflow and accuracy compared with the ThinPrep Imaging System for review of ThinPrep Papanicolaou tests.
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| Title: | Impact of the Genius Digital Diagnostics System on workflow and accuracy compared with the ThinPrep Imaging System for review of ThinPrep Papanicolaou tests. |
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| Authors: | Murphy KM; ProPath, A Sonic Healthcare Anatomic Pathology Practice, Dallas, TX, United States., Weatherhead K; ProPath, A Sonic Healthcare Anatomic Pathology Practice, Dallas, TX, United States., Chenault C; ProPath, A Sonic Healthcare Anatomic Pathology Practice, Dallas, TX, United States., Nguyen C; ProPath, A Sonic Healthcare Anatomic Pathology Practice, Dallas, TX, United States., Sefcik K; ProPath, A Sonic Healthcare Anatomic Pathology Practice, Dallas, TX, United States., Harrington S; Scientific Affairs Department, Hologic, Inc, Marlborough, MA, United States., Johnson K; Scientific Affairs Department, Hologic, Inc, Marlborough, MA, United States., Lemeshev Y; ProPath, A Sonic Healthcare Anatomic Pathology Practice, Dallas, TX, United States. |
| Source: | American journal of clinical pathology [Am J Clin Pathol] 2025 Nov 19; Vol. 164 (5), pp. 746-751. |
| Publication Type: | Journal Article; Comparative Study |
| Language: | English |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0370470 Publication Model: Print Cited Medium: Internet ISSN: 1943-7722 (Electronic) Linking ISSN: 00029173 NLM ISO Abbreviation: Am J Clin Pathol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2016- : Oxford : Oxford University Press Original Publication: Philadelphia [etc.] Lippincott [etc.] |
| MeSH Terms: | Workflow* , Papanicolaou Test*/methods , Vaginal Smears*/methods , Uterine Cervical Neoplasms*/diagnosis, Humans ; Female |
| Abstract: | Objective: In this study, we compared the workflow of the Genius Digital Diagnostics System (Hologic, Inc) with our current workflow based on the ThinPrep Imaging System (Hologic, Inc) to assess potential efficiencies associated with digitalization of Papanicolaou screening. Methods: Each step of the current workflow (glass slide movement and slide review) and the experimental workflow were documented. Substantial workflow efficiencies were associated with the reduction of glass slide movement observed with the experimental workflow of the Genius system compared with the ThinPrep system. Results: The ThinPrep-based workflow required more than 5 hours of hands-on time at specific synchronized times throughout the day, whereas the hands-on time of the experimental Genius Digital Diagnostics System was just over an hour and allowed glass movement at flexible times. In addition to these workflow efficiencies, the Genius Digital Diagnostics System resulted in much shorter review times (70.1 seconds) than the ThinPrep Imaging system (138.0 seconds) while maintaining similar agreement to the sign-out diagnosis. Conclusions: This study demonstrated that implementing a Genius Dx-based workflow may result in substantial efficiency gains, which can mitigate workforce shortages and improve turnaround time without compromising screening accuracy. (© American Society for Clinical Pathology, 2025.) |
| References: | J Pathol Inform. 2018 Nov 14;9:38. (PMID: 30607305) Diagn Cytopathol. 2007 Sep;35(9):550-4. (PMID: 17703458) Am J Clin Pathol. 2005 Feb;123(2):281-7. (PMID: 15842055) Cancer Cytopathol. 2023 Jul;131(7):424-432. (PMID: 37068094) Rev Obstet Gynecol. 2011;4(Suppl 1):S2-S11. (PMID: 21617785) J Pathol Inform. 2016 Jul 26;7:29. (PMID: 27563488) Arch Pathol Lab Med. 2004 Jan;128(1):17-22. (PMID: 14692817) Acta Cytol. 2006 Sep-Oct;50(5):483-91. (PMID: 17017432) J Pathol Inform. 2024 Jul 02;15:100391. (PMID: 39114431) Gynecol Oncol. 2019 Jul;154(1):3-7. (PMID: 30995961) Diagn Cytopathol. 2007 Jun;35(6):348-52. (PMID: 17497655) Rev Esp Patol. 2024 Jul-Sep;57(3):182-189. (PMID: 38971618) |
| Grant Information: | Hologic, Inc |
| Contributed Indexing: | Keywords: Genius Digital Diagnostics System; Papanicolaou test; artificial intelligence; cervical cancer; cytology; cytopathology; digital cytology; digital pathology; lab efficiency; workflow |
| Entry Date(s): | Date Created: 20250925 Date Completed: 20251119 Latest Revision: 20251122 |
| Update Code: | 20251122 |
| PubMed Central ID: | PMC12629871 |
| DOI: | 10.1093/ajcp/aqaf099 |
| PMID: | 40994090 |
| Database: | MEDLINE |
Nájsť tento článok vo Web of Science | Abstract: | Objective: In this study, we compared the workflow of the Genius Digital Diagnostics System (Hologic, Inc) with our current workflow based on the ThinPrep Imaging System (Hologic, Inc) to assess potential efficiencies associated with digitalization of Papanicolaou screening.<br />Methods: Each step of the current workflow (glass slide movement and slide review) and the experimental workflow were documented. Substantial workflow efficiencies were associated with the reduction of glass slide movement observed with the experimental workflow of the Genius system compared with the ThinPrep system.<br />Results: The ThinPrep-based workflow required more than 5 hours of hands-on time at specific synchronized times throughout the day, whereas the hands-on time of the experimental Genius Digital Diagnostics System was just over an hour and allowed glass movement at flexible times. In addition to these workflow efficiencies, the Genius Digital Diagnostics System resulted in much shorter review times (70.1 seconds) than the ThinPrep Imaging system (138.0 seconds) while maintaining similar agreement to the sign-out diagnosis.<br />Conclusions: This study demonstrated that implementing a Genius Dx-based workflow may result in substantial efficiency gains, which can mitigate workforce shortages and improve turnaround time without compromising screening accuracy.<br /> (© American Society for Clinical Pathology, 2025.) |
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| ISSN: | 1943-7722 |
| DOI: | 10.1093/ajcp/aqaf099 |