Co-feeding transmission of Heartland virus between the North American tick, Amblyomma americanum (Acari: Ixodidae), and the invasive East Asian tick, Haemaphysalis longicornis (Acari: Ixodidae).
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| Název: | Co-feeding transmission of Heartland virus between the North American tick, Amblyomma americanum (Acari: Ixodidae), and the invasive East Asian tick, Haemaphysalis longicornis (Acari: Ixodidae). |
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| Autoři: | Norman PD; Department of Microbiology and Immunology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA., Garba A; Department of Microbiology and Immunology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA., Obellianne C; Department of Microbiology and Immunology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA., Hermance ME; Department of Microbiology and Immunology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA. |
| Zdroj: | Journal of medical entomology [J Med Entomol] 2025 Nov 01; Vol. 62 (6), pp. 1530-1539. |
| Způsob vydávání: | Journal Article |
| Jazyk: | English |
| Informace o časopise: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0375400 Publication Model: Print Cited Medium: Internet ISSN: 1938-2928 (Electronic) Linking ISSN: 00222585 NLM ISO Abbreviation: J Med Entomol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2015- : Oxford, UK : Oxford University Press Original Publication: Honolulu, Entomology Dept., B. P. Bishop Museum. |
| Výrazy ze slovníku MeSH: | Ixodidae*/virology , Ixodidae*/physiology , Amblyomma*/virology , Amblyomma*/physiology , Reoviridae Infections*/transmission , Arachnid Vectors*/virology , Arachnid Vectors*/physiology, Animals ; Mice ; Female ; Introduced Species ; Feeding Behavior ; Nymph/virology ; Nymph/physiology ; Haemaphysalis longicornis ; Bunyaviridae |
| Abstrakt: | Haemaphysalis longicornis Neumann is an invasive tick species from East Asia with a rapidly expanding geographic range in the United States. In a laboratory setting, H. longicornis has been shown to support transovarial transmission of Heartland virus (HRTV; genus Bandavirus), an emerging tick-borne pathogen responsible for human disease in the southern and midwestern United States. The native Amblyomma americanum (L.) is the primary known vector of HRTV, and field surveillance studies have documented co-feeding of H. longicornis and A. americanum on shared hosts, raising questions about the potential for interspecies viral transmission. To investigate whether H. longicornis can acquire HRTV through co-feeding with infected A. americanum, we used a mouse model in which HRTV-infected A. americanum nymphs were co-fed with uninfected H. longicornis larvae or nymphs and screened recipient ticks using q-RT-PCR. HRTV RNA was detected in H. longicornis collected from multiple mice, demonstrating interspecies co-feeding transmission of HRTV. Mouse blood samples were consistently negative for HRTV RNA, while some skin biopsies from tick feeding sites were positive for the virus, indicating nonviremic co-feeding transmission. These findings provide the first experimental evidence that H. longicornis can acquire HRTV RNA through co-feeding with A. americanum and could contribute to its maintenance in nature, even in the absence of a known vertebrate reservoir host for HRTV. (© The Author(s) 2025. Published by Oxford University Press on behalf of Entomological Society of America.) |
| References: | Am J Trop Med Hyg. 2018 Apr;98(4):1194-1196. (PMID: 29488458) Emerg Infect Dis. 2016 Dec;22(12):2070-2077. (PMID: 27869591) Sci Rep. 2023 Aug 16;13(1):13304. (PMID: 37587216) Viruses. 2018 Sep 14;10(9):. (PMID: 30223439) N Z Vet J. 2016 Jan;64(1):10-20. (PMID: 25849758) Emerg Infect Dis. 2022 Mar;28(3):726-729. (PMID: 35202534) Emerg Infect Dis. 2015 Oct;21(10):1830-3. (PMID: 26401988) J Med Entomol. 2014 Mar;51(2):342-51. (PMID: 24724282) J Med Entomol. 2016 May;53(3):607-612. (PMID: 27032416) J Med Entomol. 1993 Jan;30(1):295-9. (PMID: 8433342) Zookeys. 2019 Jan 23;(818):117-128. (PMID: 30766418) Am J Trop Med Hyg. 2013 Sep;89(3):445-452. (PMID: 23878186) Parasit Vectors. 2022 Sep 20;15(1):331. (PMID: 36127708) Int J Environ Res Public Health. 2020 Nov 09;17(21):. (PMID: 33182472) Emerg Infect Dis. 2022 Apr;28(4):786-792. (PMID: 35318917) Microorganisms. 2024 Apr 30;12(5):. (PMID: 38792729) Science. 1987 Aug 14;237(4816):775-7. (PMID: 3616608) Am J Trop Med Hyg. 2015 Jun;92(6):1163-7. (PMID: 25870419) Microorganisms. 2024 Jan 29;12(2):. (PMID: 38399689) Zoonoses Public Health. 2020 Sep;67(6):637-650. (PMID: 32638553) J Med Entomol. 2021 Mar 12;58(2):873-879. (PMID: 33710315) J Med Entomol. 2018 May 4;55(3):757-759. (PMID: 29471482) Emerg Infect Dis. 2019 Feb;25(2):358-360. (PMID: 30511916) N Engl J Med. 2012 Aug 30;367(9):834-41. (PMID: 22931317) Int J Parasitol. 2021 Feb;51(2-3):149-157. (PMID: 33130214) J Med Entomol. 2018 May 4;55(3):701-705. (PMID: 29365128) J Parasitol. 1968 Dec;54(6):1197-213. (PMID: 5757695) Ticks Tick Borne Dis. 2023 Jan;14(1):102080. (PMID: 36375268) J Med Entomol. 2016 Sep 1;53(5):1226-1233. (PMID: 27330103) Parasit Vectors. 2024 Jun 15;17(1):259. (PMID: 38879603) PLoS One. 2010 Jul 23;5(7):e11745. (PMID: 20668521) J Virol. 2015 Aug;89(15):7852-60. (PMID: 25995246) STAR Protoc. 2025 Sep 19;6(3):103925. (PMID: 40591457) PLoS One. 2024 Jun 10;19(6):e0304959. (PMID: 38857239) |
| Grant Information: | R01 AI171398 United States AI NIAID NIH HHS; R21 AI163693 United States AI NIAID NIH HHS |
| SCR Organism: | Heartland virus |
| Entry Date(s): | Date Created: 20250923 Date Completed: 20251114 Latest Revision: 20251117 |
| Update Code: | 20251117 |
| PubMed Central ID: | PMC12616231 |
| DOI: | 10.1093/jme/tjaf110 |
| PMID: | 40985580 |
| Databáze: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Haemaphysalis longicornis Neumann is an invasive tick species from East Asia with a rapidly expanding geographic range in the United States. In a laboratory setting, H. longicornis has been shown to support transovarial transmission of Heartland virus (HRTV; genus Bandavirus), an emerging tick-borne pathogen responsible for human disease in the southern and midwestern United States. The native Amblyomma americanum (L.) is the primary known vector of HRTV, and field surveillance studies have documented co-feeding of H. longicornis and A. americanum on shared hosts, raising questions about the potential for interspecies viral transmission. To investigate whether H. longicornis can acquire HRTV through co-feeding with infected A. americanum, we used a mouse model in which HRTV-infected A. americanum nymphs were co-fed with uninfected H. longicornis larvae or nymphs and screened recipient ticks using q-RT-PCR. HRTV RNA was detected in H. longicornis collected from multiple mice, demonstrating interspecies co-feeding transmission of HRTV. Mouse blood samples were consistently negative for HRTV RNA, while some skin biopsies from tick feeding sites were positive for the virus, indicating nonviremic co-feeding transmission. These findings provide the first experimental evidence that H. longicornis can acquire HRTV RNA through co-feeding with A. americanum and could contribute to its maintenance in nature, even in the absence of a known vertebrate reservoir host for HRTV.<br /> (© The Author(s) 2025. Published by Oxford University Press on behalf of Entomological Society of America.) |
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| ISSN: | 1938-2928 |
| DOI: | 10.1093/jme/tjaf110 |