Extremely low-frequency magnetic fields (ELF-MF) and radiofrequency: Risk of childhood CNS tumors in a city with elevated ELF-MF exposure.
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| Titel: | Extremely low-frequency magnetic fields (ELF-MF) and radiofrequency: Risk of childhood CNS tumors in a city with elevated ELF-MF exposure. |
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| Autoren: | Correa-Correa V; Departamento de Neurocirugía, Hospital de Especialidades 'Dr. Bernardo Sepúlveda Gutiérrez,' 'CMN Siglo XXI,' IMSS, Mexico City, Mexico., Núñez-Enríquez JC; División de Investigación en Salud, Unidad Médica de Alta Especialidad (UMAE), Hospital de Pediatría 'Dr. Silvestre Frenk Freund', Centro Médico Nacional (CMN) 'Siglo XXI,' Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico., Mezei G; Health Sciences, Exponent, Inc., 474 14th Street, Suite 400, Oakland, CA, 94612, USA., Rivera-Luna R; Departamento de Oncología, INP, SS, Mexico City, Mexico., Peñaloza-González JG; Departamento de Onco-Pediatría, Hospital Juárez de México, SS, Mexico City, Mexico., Rivas-Carrillo SD; Laboratorio de Genómica del Cancer, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico; Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México City, Mexico., Ortiz-Mejía CG; Departamento de Neurocirugía. Centro Medico Nacional 20 de Noviembre, ISSSTE, Mexico City, Mexico., Flores-Robles C; Departamento de Neurocirugía pediátrica, Hospital General 'Gaudencio González Garza' Centro Médico Nacional La Raza. Instituto Mexicano del Seguro Social (IMSS). Mexico City, Mexico., Velasco-Ramírez E; Departamento de Neurocirugía pediátrica, Hospital General 'Gaudencio González Garza' Centro Médico Nacional La Raza. Instituto Mexicano del Seguro Social (IMSS). Mexico City, Mexico., Alexis Del Real-Gallegos M; Departamento de Neurocirugía pediátrica, Hospital General 'Gaudencio González Garza' Centro Médico Nacional La Raza. Instituto Mexicano del Seguro Social (IMSS). Mexico City, Mexico., Flores-Lujano J; Unidad de Investigación Médica en Epidemiología Clínica, Unidad Médica de Alta Especialidad (UMAE), Hospital de Pediatría, Centro Médico Nacional (CMN) 'Siglo XXI,' Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico., Flores-Pérez FV; Laboratorio de Genómica del Cancer, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico; Ingeniería en Biotecnología. Instituto Tecnológico de Estudios Superiores Monterey (ITESM), Campus Ciudad de Mexico, Mexico City, Mexico., Sánchez-Rodríguez G; Departamento de Neurocirugía, UMAE Hospital de Pediatría, CMN 'Siglo XXI,' IMSS, Mexico City, Mexico., Ramírez-Reyes AG; Departamento de Neurocirugía, UMAE Hospital de Pediatría, CMN 'Siglo XXI,' IMSS, Mexico City, Mexico., López-Aguilar E; Departamento de Oncología, UMAE Hospital de Pediatría, CMN 'Siglo XXI,' IMSS, Mexico City, Mexico., Duarte-Rodríguez DA; Coordinación de Investigación en Salud, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico., Anaya-López S; Departamento de Oncología pediátrica, Hospital General 'Gaudencio González Garza' Centro Médico Nacional La Raza. Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico., Pérez-Saldívar ML; Unidad de Investigación Médica en Epidemiología Clínica, Unidad Médica de Alta Especialidad (UMAE), Hospital de Pediatría, Centro Médico Nacional (CMN) 'Siglo XXI,' Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico., Chico-Ponce-de-León F; Departamento de Neurocirugía, Hospital Infantil de México Federico Gómez, Secretaria de Salud (SS), Mexico City, Mexico., Jimenez-Morales S; Laboratorio de Medicina de Precisión, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico., González-Carranza V; Departamento de Neurocirugía, Hospital Infantil de México Federico Gómez, Secretaria de Salud (SS), Mexico City, Mexico., Mata-Rocha M; CONACyT-Unidad de Investigacion Medica en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico; Unidad de Investigacion Medica en Genética Humana, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico., Marhx-Bracho A; Departamento de Neurocirugía, INP, SS, Mexico City, Mexico., Rosas-Vargas H; Unidad de Investigacion Medica en Genética Humana, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico., Godoy-Esquivel AH; Departamento de Cirugía Pediátrica, Hospital Pediátrico 'Moctezuma,' Secretaría de Salud de la Ciudad de México (SSCDMX), Mexico City, Mexico., García-Cortés J; Departamento de Cirugía Pediátrica, Hospital Pediátrico 'Coyoacán', Secretaría de Salud de la Ciudad de México (SSCDMX), Mexico City, Mexico., Delgadillo-Bono O; Departamento de Cirugía Pediátrica, Hospital Pediátrico 'Tacubaya', Secretaría de Salud de la Ciudad de México (SSCDMX), Mexico City, Mexico., Jaimes G; Departamento de Cirugía Pediátrica, Hospital Pediátrico 'Azcapotzalco', Secretaría de Salud de la Ciudad de México (SSCDMX), Mexico City, Mexico., Ramírez-Marroquín J; Departamento de Cirugía Pediátrica, Hospital Pediátrico 'La Villa', Secretaría de Salud de la Ciudad de México (SSCDMX), Mexico City, Mexico., Flores-Galicia P; Departamento de Cirugía Pediátrica, Hospital Pediátrico 'San Juan de Aragón', Secretaría de Salud de la Ciudad de México (SSCDMX), Mexico City, Mexico., Contreras-Frias C; Coordinación de Educacion e Investigación en Salud, Hospital General Regional No 1 'Dr. Carlos Mac Gregor Sánchez Navarro,' IMSS, Mexico City, Mexico., Campos-Rodríguez UE; Departamento de Neurocirugía, UMAE Hospital de Pediatría, CMN 'Siglo XXI,' IMSS, Mexico City, Mexico., Hernández-Chávez E; Departamento de Neurocirugía, Hospital de Especialidades 'Dr. Bernardo Sepúlveda Gutiérrez,' 'CMN Siglo XXI,' IMSS, Mexico City, Mexico., Meléndez-Zajgla J; Laboratorio de Genomica Funcional del Cancer, Instituto Nacional de Medicina Genomica (INMEGEN), Mexico City, Mexico., Medina-Sanson A; Departamento de Hemato-Oncología, Hospital Infantil de México Federico Gómez, Secretaria de Salud (SS), Mexico City, Mexico. Electronic address: auroramedina@aol.com.mx., Mejía-Aranguré JM; Laboratorio de Genomica Funcional del Cancer, Instituto Nacional de Medicina Genomica (INMEGEN), Mexico City, Mexico. Electronic address: jmejia@inmegen.gob.mx. |
| Quelle: | Environmental research [Environ Res] 2025 Dec 01; Vol. 286 (Pt 2), pp. 122858. Date of Electronic Publication: 2025 Sep 14. |
| Publikationsart: | Journal Article |
| Sprache: | English |
| Info zur Zeitschrift: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0147621 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0953 (Electronic) Linking ISSN: 00139351 NLM ISO Abbreviation: Environ Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2000- > : Amsterdam : Elsevier Original Publication: New York, Academic Press. |
| MeSH-Schlagworte: | Radio Waves*/adverse effects , Central Nervous System Neoplasms*/epidemiology , Central Nervous System Neoplasms*/etiology , Environmental Exposure*/adverse effects , Magnetic Fields*/adverse effects , Electromagnetic Fields*/adverse effects, Humans ; Mexico/epidemiology ; Child ; Case-Control Studies ; Male ; Female ; Child, Preschool ; Adolescent ; Infant ; Cities/epidemiology |
| Abstract: | Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Background: Central nervous system tumors (CNSTs) are the second most common childhood cancer. While their etiology is unclear, exposure to extremely low-frequency magnetic fields (ELF-MF) and radiofrequency (RF) may be associated with increased risk. This study aims to examine the relationship between ELF-MF and RF exposure and CNST risk in Mexico City's pediatric population. Methods: A case-control study was conducted in Mexico City (2017-2022), to assess ELF-MF and RF exposure in 200 CNST patients and 793 controls under 16 years old. Residential ELF-MF exposure was measured over 24 h, and RF exposure was assessed through the total duration of cell phone calls and electronic device usage (with and without internet). ELF-MF exposure levels below 0.1 μT and the lowest RF exposure quartile (Q1) served as reference groups for adjusted odds ratio (aOR) analyses. Data analysis was performed using R and SPSS software. Results: Of all participants, 5.1 % had ELF-MF exposure ≥0.3 μT. Elevated ELF-MF exposure (≥0.4 μT) was significantly associated with an increased risk of CNST (aOR (95 % confidence interval) = 2.39 (1.15-5.00). While cell phone use showed no differences between cases and controls, prolonged tablet use (with and without internet) was significantly associated with increased CNST risk (aOR = 2.53 (1.39-4.61), and 3.53 (1.45-8.59), respectively). Conclusion: A high proportion of children in Mexico City are exposed to ELF-MF levels ≥0.3 μT, exceeding levels reported in other populations. Elevated residential ELF-MF exposure, as well as prolonged tablet use, both with and without internet connectivity, were significantly associated with an increased risk of developing CNST in childhood. (Copyright © 2025 Elsevier Inc. All rights reserved.) |
| Kommentare: | Erratum in: Environ Res. 2025 Dec 1;286(Pt 3):123001. doi: 10.1016/j.envres.2025.123001.. (PMID: 41045572) |
| Contributed Indexing: | Keywords: Cancer; Case–control study; Children; Environmental factors; Etiology |
| Entry Date(s): | Date Created: 20250916 Date Completed: 20251104 Latest Revision: 20251104 |
| Update Code: | 20251104 |
| DOI: | 10.1016/j.envres.2025.122858 |
| PMID: | 40957475 |
| Datenbank: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstract: | Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br />Background: Central nervous system tumors (CNSTs) are the second most common childhood cancer. While their etiology is unclear, exposure to extremely low-frequency magnetic fields (ELF-MF) and radiofrequency (RF) may be associated with increased risk. This study aims to examine the relationship between ELF-MF and RF exposure and CNST risk in Mexico City's pediatric population.<br />Methods: A case-control study was conducted in Mexico City (2017-2022), to assess ELF-MF and RF exposure in 200 CNST patients and 793 controls under 16 years old. Residential ELF-MF exposure was measured over 24 h, and RF exposure was assessed through the total duration of cell phone calls and electronic device usage (with and without internet). ELF-MF exposure levels below 0.1 μT and the lowest RF exposure quartile (Q1) served as reference groups for adjusted odds ratio (aOR) analyses. Data analysis was performed using R and SPSS software.<br />Results: Of all participants, 5.1 % had ELF-MF exposure ≥0.3 μT. Elevated ELF-MF exposure (≥0.4 μT) was significantly associated with an increased risk of CNST (aOR (95 % confidence interval) = 2.39 (1.15-5.00). While cell phone use showed no differences between cases and controls, prolonged tablet use (with and without internet) was significantly associated with increased CNST risk (aOR = 2.53 (1.39-4.61), and 3.53 (1.45-8.59), respectively).<br />Conclusion: A high proportion of children in Mexico City are exposed to ELF-MF levels ≥0.3 μT, exceeding levels reported in other populations. Elevated residential ELF-MF exposure, as well as prolonged tablet use, both with and without internet connectivity, were significantly associated with an increased risk of developing CNST in childhood.<br /> (Copyright © 2025 Elsevier Inc. All rights reserved.) |
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| ISSN: | 1096-0953 |
| DOI: | 10.1016/j.envres.2025.122858 |