The modified spatial context memory test for assessing cognitive aging in middle-aged and older adults.
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| Title: | The modified spatial context memory test for assessing cognitive aging in middle-aged and older adults. |
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| Authors: | Wang HM; Department of Psychiatry, Chang Gung Memorial Hospital at Chiayi, Chiayi 61363, Taiwan., Huang YP; Department of Electrical Engineering, National Taipei University of Technology, Taipei 10608, Taiwan., Kuo HY; Inter-Disciplinary Bachelor's Program, National Taiwan University of Science and Technology, Taipei 10607, Taiwan., Kuo HC; Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan 33333, Taiwan. Electronic address: kuo0426@adm.cgmh.org.tw. |
| Source: | Neuroscience research [Neurosci Res] 2025 Nov; Vol. 220, pp. 104956. Date of Electronic Publication: 2025 Sep 10. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: Ireland NLM ID: 8500749 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8111 (Electronic) Linking ISSN: 01680102 NLM ISO Abbreviation: Neurosci Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: Limerick : Elsevier Original Publication: [Shannon : Elsevier Scientific Publishers Ireland, c1984- |
| MeSH Terms: | Cognitive Aging*/physiology , Cognitive Aging*/psychology , Spatial Memory*/physiology , Neuropsychological Tests* , Spatial Navigation*/physiology , Aging*/psychology, Humans ; Aged ; Male ; Female ; Middle Aged ; Prospective Studies |
| Abstract: | Competing Interests: Declaration of Competing Interest All authors have no conflicts of interest to declare. Deficits in spatial-context memory may be risk factors for Alzheimer disease (AD). This study aimed to investigate spatial-context memory and spatial navigation in middle-aged and older adults using a modified spatial-context memory test (SCMT). This prospective study recruited adults aged 55-75 years from our outpatient department. Non-dementia cases were confirmed by neurologists and assessed by psychologists. Age and education were analyzed as continuous variables using regression models to examine their associations with SCMT performance. A modified SCMT was established, consisting of a computer program that performed in cooperation with a spatial memory paradigm using real-world simulation. Subtests of navigation, scene-event associations and people-object associations were included. Of 147 participants, 108 met the selection criteria and were included in the analysis. Older age was linked to more errors and longer retrieval times, whereas higher education was related to shorter completion times in some SCMT-I tasks. In conclusion, SCMT-I performance was primarily influenced by age, with older participants showing increased errors and longer retrieval times across subtests. These findings suggest that age-related changes in spatial-context memory can be detected even among cognitively normal adults, and that SCMT-I may provide a sensitive tool for assessing cognitive aging independent of educational background. (Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.) |
| Contributed Indexing: | Keywords: Aging; Alzheimer disease; Amnestic mild cognitive impairment; Episodic memory; Spatial context memory test |
| Entry Date(s): | Date Created: 20250912 Date Completed: 20251106 Latest Revision: 20251106 |
| Update Code: | 20251107 |
| DOI: | 10.1016/j.neures.2025.104956 |
| PMID: | 40939809 |
| Database: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstract: | Competing Interests: Declaration of Competing Interest All authors have no conflicts of interest to declare.<br />Deficits in spatial-context memory may be risk factors for Alzheimer disease (AD). This study aimed to investigate spatial-context memory and spatial navigation in middle-aged and older adults using a modified spatial-context memory test (SCMT). This prospective study recruited adults aged 55-75 years from our outpatient department. Non-dementia cases were confirmed by neurologists and assessed by psychologists. Age and education were analyzed as continuous variables using regression models to examine their associations with SCMT performance. A modified SCMT was established, consisting of a computer program that performed in cooperation with a spatial memory paradigm using real-world simulation. Subtests of navigation, scene-event associations and people-object associations were included. Of 147 participants, 108 met the selection criteria and were included in the analysis. Older age was linked to more errors and longer retrieval times, whereas higher education was related to shorter completion times in some SCMT-I tasks. In conclusion, SCMT-I performance was primarily influenced by age, with older participants showing increased errors and longer retrieval times across subtests. These findings suggest that age-related changes in spatial-context memory can be detected even among cognitively normal adults, and that SCMT-I may provide a sensitive tool for assessing cognitive aging independent of educational background.<br /> (Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.) |
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| ISSN: | 1872-8111 |
| DOI: | 10.1016/j.neures.2025.104956 |