New insights into gut-liver axis in advanced liver diseases: A promising therapeutic target.
Gespeichert in:
| Titel: | New insights into gut-liver axis in advanced liver diseases: A promising therapeutic target. |
|---|---|
| Autoren: | Xing Y; Department of Hepatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Ou Y; Department of Hepatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Wang Y; Department of Hepatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Hou L; Department of Hepatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Zhu J; Department of Hepatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: zhujftongling@163.com. |
| Quelle: | Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 2), pp. 117284. Date of Electronic Publication: 2025 Sep 03. |
| Publikationsart: | Journal Article; Review |
| Sprache: | English |
| Info zur Zeitschrift: | Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Oxford : Elsevier Science Original Publication: Oxford, New York [etc.] Paragamon Press. |
| MeSH-Schlagworte: | Gastrointestinal Microbiome*/physiology , Gastrointestinal Microbiome*/drug effects , Liver*/metabolism , Liver*/drug effects , Liver Diseases*/metabolism , Liver Diseases*/drug therapy , Liver Diseases*/microbiology, Humans ; Animals ; Dysbiosis ; Liver Cirrhosis/metabolism ; Intestinal Mucosa/metabolism |
| Abstract: | Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The gut-liver axis constitutes a bidirectional communication network that integrates the microbial microenvironment, metabolism, and immune signals between the gut and the liver. Currently, there is compelling evidence indicating that the overall dysfunction of the gut-liver axis is a pivotal driver in the pathogenesis of advanced liver diseases. This review focuses on the latest research progress regarding various components of the intestinal barrier and how these components contribute to the onset and progression of cirrhosis and its complications. Chronic exposure to multifactorial stressors can result in irreversible damage to intestinal physical barriers, microbial dysbiosis, and immune dysregulation. These cumulative perturbations within the gut-liver axis promote pathogenic microbial translocation, initiate systemic inflammatory responses, and expedite disease progression. A more in-depth understanding of the gut-liver crosstalk mechanism is anticipated to offer novel therapeutic strategies for restoring microbiota-targeted intestinal homeostasis, which may lead to functional recompensation in decompensated cirrhosis. (Copyright © 2025 Elsevier Inc. All rights reserved.) |
| Contributed Indexing: | Keywords: Advanced liver diseases; Cirrhosis; Gut microbiota; Gut-liver axis; Intestinal barrier |
| Entry Date(s): | Date Created: 20250905 Date Completed: 20251028 Latest Revision: 20251028 |
| Update Code: | 20251029 |
| DOI: | 10.1016/j.bcp.2025.117284 |
| PMID: | 40912372 |
| Datenbank: | MEDLINE |
Full Text Finder 
Nájsť tento článok vo Web of Science | Abstract: | Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br />The gut-liver axis constitutes a bidirectional communication network that integrates the microbial microenvironment, metabolism, and immune signals between the gut and the liver. Currently, there is compelling evidence indicating that the overall dysfunction of the gut-liver axis is a pivotal driver in the pathogenesis of advanced liver diseases. This review focuses on the latest research progress regarding various components of the intestinal barrier and how these components contribute to the onset and progression of cirrhosis and its complications. Chronic exposure to multifactorial stressors can result in irreversible damage to intestinal physical barriers, microbial dysbiosis, and immune dysregulation. These cumulative perturbations within the gut-liver axis promote pathogenic microbial translocation, initiate systemic inflammatory responses, and expedite disease progression. A more in-depth understanding of the gut-liver crosstalk mechanism is anticipated to offer novel therapeutic strategies for restoring microbiota-targeted intestinal homeostasis, which may lead to functional recompensation in decompensated cirrhosis.<br /> (Copyright © 2025 Elsevier Inc. All rights reserved.) |
|---|---|
| ISSN: | 1873-2968 |
| DOI: | 10.1016/j.bcp.2025.117284 |