Maternal Anthropometry, Body Composition, and Fat Distribution by HIV Status and Antiretroviral Therapy Class in South African Women.
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| Titel: | Maternal Anthropometry, Body Composition, and Fat Distribution by HIV Status and Antiretroviral Therapy Class in South African Women. |
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| Autoren: | Madlala HP; Division of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Cape Town, South Africa., Myer L; Division of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Cape Town, South Africa., Geffen H; Division of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Cape Town, South Africa., Jao J; Division of Infectious Diseases, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Matjila M; Department of Obstetrics & Gynaecology, University of Cape Town, Groote Schuur and New Somerset Hospitals, Cape Town, South Africa., Fisher A; Division of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Cape Town, South Africa., Meyer D; Division of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Cape Town, South Africa., Dugas L; Division of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Cape Town, South Africa.; Public Health Sciences, Parkinson School of Health Sciences & Public Health, Loyola University Chicago, Maywood, Illinois, USA., Mendham AE; Riverland Academy of Clinical Excellence (RACE), Riverland Mallee Coorong Local Health Network, South Australia Health, Berri, Australia.; Health through Physical Activity, Lifestyle and Sport Research Centre (HPALS), FIMS International Collaborating Centre of Sports Medicine, Division of Physiological Sciences, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Petro G; Department of Obstetrics & Gynaecology, University of Cape Town, Groote Schuur and New Somerset Hospitals, Cape Town, South Africa., Cu-Uvin S; Department of Obstetrics and Gynaecology and Medicine, Warren Alpert School of Medicine, Brown University, Providence, Rhode Island, USA., McGarvey ST; Department of Epidemiology and International Health Institute, School of Public Health, Brown University, Providence, Rhode Island, USA., Goedecke JH; Health through Physical Activity, Lifestyle and Sport Research Centre (HPALS), FIMS International Collaborating Centre of Sports Medicine, Division of Physiological Sciences, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; Biomedical Research and Innovation Platform, South African Medical Research Council, Cape Town, South Africa., Bengtson AM; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA. |
| Quelle: | AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2025 Dec; Vol. 41 (12), pp. 588-597. Date of Electronic Publication: 2025 Sep 03. |
| Publikationsart: | Journal Article |
| Sprache: | English |
| Info zur Zeitschrift: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8709376 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-8405 (Electronic) Linking ISSN: 08892229 NLM ISO Abbreviation: AIDS Res Hum Retroviruses Subsets: MEDLINE |
| Imprint Name(s): | Publication: Larchmont, NY : Mary Ann Liebert Original Publication: [New York] : Mary Ann Liebert, [c1987- |
| MeSH-Schlagworte: | HIV Infections*/drug therapy , HIV Infections*/complications , Pregnancy Complications, Infectious*/drug therapy , Body Composition* , Anti-Retroviral Agents*/therapeutic use , Body Fat Distribution* , Anti-HIV Agents*/therapeutic use, Humans ; Female ; Adult ; Pregnancy ; South Africa/epidemiology ; Cross-Sectional Studies ; Anthropometry ; Postpartum Period ; Adiposity ; Young Adult ; Longitudinal Studies |
| Abstract: | Pregnancy affects adiposity, which may be influenced by HIV infection or antiretroviral therapy (ART). The objective of this study was to examine adiposity measures in the perinatal period, by HIV status and ART class. A total of 214 women (113 women with HIV [WWH], 71 initiated ART postconception), enrolled between 24 and 28 weeks of gestation and followed until 6-12 months postpartum, were assessed for longitudinal weight and cross-sectional postpartum anthropometry. A subset of 65 (52 WWH, 42 initiated ART postconception) had cross-sectional adiposity (body composition and fat distribution) measured at 6-12 months postpartum using dual-energy X-ray absorption scan. Multivariable linear and modified Poisson regression, adjusted for maternal age, pre-pregnancy body mass index, socioeconomic status, and postpartum months, examined associations of HIV status and postconception ART (dolutegravir-based [DTG] vs. efavirenz-based [EFV]) with anthropometry and adiposity outcomes. At enrollment, the median age was 30 years (interquartile range, 26-34) and 82% were multiparous. Between pre-pregnancy and postpartum, women gained an average of 2.33 kg (0.90 kg WWH), 30% lost weight (35% WWH), and 48% gained weight (38% WWH). WWH gained weight slower during pregnancy (0.27 vs 0.38 kg/week, p = .03) and were less likely to gain weight postpartum (RR = 0.72 95% CI 0.55, 0.93; p = .01) compared with women without HIV. Postpartum, mean body mass index was 32 kg/m 2 (standard deviation = 7.33) and 58% (53% WWH) of women had obesity. HIV was not associated with cross-sectional measures of postpartum anthropometry and adiposity. Among WWH, compared with EFV-based ART, DTG-based ART was not associated with weight gain during pregnancy or anthropometry and adiposity postpartum. Despite high rates of postpartum weight gain and obesity, no significant differences were observed in anthropometry and adiposity measures by HIV status and postconception ART. Nonetheless, these findings underscore the need for interventions to support healthy weight gain in pregnancy and postpartum weight loss to minimize pregnancy-associated obesity. |
| Contributed Indexing: | Keywords: HIV; antiretroviral therapy; body composition; fat distribution; obesity; perinatal |
| Substance Nomenclature: | 0 (Anti-Retroviral Agents) 0 (Anti-HIV Agents) |
| Entry Date(s): | Date Created: 20250903 Date Completed: 20251124 Latest Revision: 20251124 |
| Update Code: | 20251124 |
| DOI: | 10.1177/08892229251374692 |
| PMID: | 40903037 |
| Datenbank: | MEDLINE |
Nájsť tento článok vo Web of Science | Abstract: | Pregnancy affects adiposity, which may be influenced by HIV infection or antiretroviral therapy (ART). The objective of this study was to examine adiposity measures in the perinatal period, by HIV status and ART class. A total of 214 women (113 women with HIV [WWH], 71 initiated ART postconception), enrolled between 24 and 28 weeks of gestation and followed until 6-12 months postpartum, were assessed for longitudinal weight and cross-sectional postpartum anthropometry. A subset of 65 (52 WWH, 42 initiated ART postconception) had cross-sectional adiposity (body composition and fat distribution) measured at 6-12 months postpartum using dual-energy X-ray absorption scan. Multivariable linear and modified Poisson regression, adjusted for maternal age, pre-pregnancy body mass index, socioeconomic status, and postpartum months, examined associations of HIV status and postconception ART (dolutegravir-based [DTG] vs. efavirenz-based [EFV]) with anthropometry and adiposity outcomes. At enrollment, the median age was 30 years (interquartile range, 26-34) and 82% were multiparous. Between pre-pregnancy and postpartum, women gained an average of 2.33 kg (0.90 kg WWH), 30% lost weight (35% WWH), and 48% gained weight (38% WWH). WWH gained weight slower during pregnancy (0.27 vs 0.38 kg/week, p = .03) and were less likely to gain weight postpartum (RR = 0.72 95% CI 0.55, 0.93; p = .01) compared with women without HIV. Postpartum, mean body mass index was 32 kg/m <sup>2</sup> (standard deviation = 7.33) and 58% (53% WWH) of women had obesity. HIV was not associated with cross-sectional measures of postpartum anthropometry and adiposity. Among WWH, compared with EFV-based ART, DTG-based ART was not associated with weight gain during pregnancy or anthropometry and adiposity postpartum. Despite high rates of postpartum weight gain and obesity, no significant differences were observed in anthropometry and adiposity measures by HIV status and postconception ART. Nonetheless, these findings underscore the need for interventions to support healthy weight gain in pregnancy and postpartum weight loss to minimize pregnancy-associated obesity. |
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| ISSN: | 1931-8405 |
| DOI: | 10.1177/08892229251374692 |