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Evaluating breast lesions with ultrafast DCE-MRI: The impact of temporal resolution on pharmacokinetics.

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Názov: Evaluating breast lesions with ultrafast DCE-MRI: The impact of temporal resolution on pharmacokinetics.
Autori: Xie T; Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Huang Y; Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Fu C; MR Applications Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China., Grimm R; Research & Clinical Translation, Magnetic Resonance, Siemens Healthineers AG, Erlangen, Germany., Nickel MD; Research & Clinical Translation, Magnetic Resonance, Siemens Healthineers AG, Erlangen, Germany., Xiao Q; Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Peng W; Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Li R; Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: liruimin009@163.com., Gu Y; Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: guyajia@126.com.
Zdroj: Magnetic resonance imaging [Magn Reson Imaging] 2025 Dec; Vol. 124, pp. 110512. Date of Electronic Publication: 2025 Sep 01.
Spôsob vydávania: Journal Article
Jazyk: English
Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8214883 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5894 (Electronic) Linking ISSN: 0730725X NLM ISO Abbreviation: Magn Reson Imaging Subsets: MEDLINE
Imprint Name(s): Publication: <2008->: Amsterdam : Elsevier
Original Publication: New York : Pergamon, c1982-
Výrazy zo slovníka MeSH: Contrast Media*/pharmacokinetics , Breast Neoplasms*/diagnostic imaging , Magnetic Resonance Imaging*/methods, Humans ; Female ; Middle Aged ; Prospective Studies ; Adult ; Aged ; Breast/diagnostic imaging ; Image Processing, Computer-Assisted/methods ; Image Interpretation, Computer-Assisted/methods ; Dynamic Contrast Enhanced Magnetic Resonance Imaging
Abstrakt: Objective: This study aimed to evaluate the impact of temporal resolution on pharmacokinetic parameters and the performance in diagnosing breast cancer.
Methods: This prospective study included 89 consecutive patients with 97 lesions (76 malignant and 21 benign). Ultrafast dynamic contrast-enhanced (UF-DCE) imaging was performed on a 3-T MRI scanner using CAIPIRINHA-Dixon-TWIST-VIBE (CDTV) with a native temporal resolution of 4.5 s per phase. The CDTV data were downsampled at various temporal resolutions ranging from 9.0 to 58.5 s, creating eight additional datasets. Pharmacokinetic parameters, including K trans , k ep , and v e , were calculated using Tofts model and population-based arterial input function (AIF). Paired-sample t-test with Bonferroni correction and ROC curves were used for statistical analysis.
Results: As temporal resolution decreased from 4.5 s, K trans and k ep values increased, while v e values decreased. The AUCs of K trans , k ep , and v e at 4.5-s temporal resolution were 0.648, 0.778, and 0.685, respectively. Temporal resolutions shorter than 18 s showed less than a 10 % deviation in K trans and k ep of quantitative parameters compared to the 4.5-s reference. No significant difference was noted among AUC pairs for any of the parameters (corrected p > 0.00625).
Conclusions: Our results revealed that the temporal resolution significantly impacted pharmacokinetic parameters based on the population-based AIF from UF-DCE MRI. However, the diagnostic ability to characterize breast cancer might not be substantially affected. A temporal resolution shorter than 18 s is recommended for accurate calculation of pharmacokinetic parameters.
(Copyright © 2025. Published by Elsevier Inc.)
Contributed Indexing: Keywords: Breast neoplasm; Kinetics; Magnetic resonance imaging; Pharmacokinetics
Substance Nomenclature: 0 (Contrast Media)
Entry Date(s): Date Created: 20250903 Date Completed: 20251025 Latest Revision: 20251025
Update Code: 20251026
DOI: 10.1016/j.mri.2025.110512
PMID: 40902958
Databáza: MEDLINE
Popis
Abstrakt:Objective: This study aimed to evaluate the impact of temporal resolution on pharmacokinetic parameters and the performance in diagnosing breast cancer.<br />Methods: This prospective study included 89 consecutive patients with 97 lesions (76 malignant and 21 benign). Ultrafast dynamic contrast-enhanced (UF-DCE) imaging was performed on a 3-T MRI scanner using CAIPIRINHA-Dixon-TWIST-VIBE (CDTV) with a native temporal resolution of 4.5 s per phase. The CDTV data were downsampled at various temporal resolutions ranging from 9.0 to 58.5 s, creating eight additional datasets. Pharmacokinetic parameters, including K <sup>trans</sup> , k <subscript>ep</subscript> , and v <subscript>e</subscript> , were calculated using Tofts model and population-based arterial input function (AIF). Paired-sample t-test with Bonferroni correction and ROC curves were used for statistical analysis.<br />Results: As temporal resolution decreased from 4.5 s, K <sup>trans</sup> and k <subscript>ep</subscript> values increased, while v <subscript>e</subscript> values decreased. The AUCs of K <sup>trans</sup> , k <subscript>ep</subscript> , and v <subscript>e</subscript> at 4.5-s temporal resolution were 0.648, 0.778, and 0.685, respectively. Temporal resolutions shorter than 18 s showed less than a 10 % deviation in K <sup>trans</sup> and k <subscript>ep</subscript> of quantitative parameters compared to the 4.5-s reference. No significant difference was noted among AUC pairs for any of the parameters (corrected p &gt; 0.00625).<br />Conclusions: Our results revealed that the temporal resolution significantly impacted pharmacokinetic parameters based on the population-based AIF from UF-DCE MRI. However, the diagnostic ability to characterize breast cancer might not be substantially affected. A temporal resolution shorter than 18 s is recommended for accurate calculation of pharmacokinetic parameters.<br /> (Copyright © 2025. Published by Elsevier Inc.)
ISSN:1873-5894
DOI:10.1016/j.mri.2025.110512