Association between time-weighted average glucose concentration or glucose variability and acute kidney injury among coronary artery disease patients with prediabetes.
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| Názov: | Association between time-weighted average glucose concentration or glucose variability and acute kidney injury among coronary artery disease patients with prediabetes. |
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| Autori: | Ren J; Division of Cardiology, Center for Coronary Artery Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China., Wang G; Division of Cardiology, Center for Coronary Artery Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China., Zhou Y; Division of Cardiology, Center for Coronary Artery Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China., Gong W; Division of Cardiology, Center for Coronary Artery Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.; Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, China.; National Clinical Research Center of Cardiovascular Diseases, Beijing, China., Zhang H; National Clinical Research Center of Cardiovascular Diseases, Beijing, China.; Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China., Yan Y; Division of Cardiology, Center for Coronary Artery Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.; Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, China.; National Clinical Research Center of Cardiovascular Diseases, Beijing, China. |
| Zdroj: | Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2549412. Date of Electronic Publication: 2025 Sep 03. |
| Spôsob vydávania: | Journal Article |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Informa Healthcare Original Publication: New York, N.Y. : M. Dekker, c1987- |
| Výrazy zo slovníka MeSH: | Prediabetic State*/complications , Prediabetic State*/blood , Acute Kidney Injury*/epidemiology , Acute Kidney Injury*/etiology , Acute Kidney Injury*/blood , Acute Kidney Injury*/prevention & control , Coronary Artery Disease*/complications , Coronary Artery Disease*/blood , Blood Glucose*/analysis, Humans ; Female ; Middle Aged ; Male ; Aged ; Incidence ; Prospective Studies ; Risk Factors ; Registries |
| Abstrakt: | Aims: To validate the effectiveness of intensive glycemic control in preventing acute kidney injury (AKI) among patients with coronary artery disease (CAD) and prediabetes. Methods: This investigation employed data from the Prospective Registry of the Current Status of Care for Patients with CAD database. Glycemic control was evaluated using the time-weighted average glucose (TWAG) and the glucose coefficient of variation (CV) for each participant. The primary outcome was AKI occurrence. Results: A total of 2,454 CAD patients with prediabetes were included between January 2022 and June 2023. The mean age was 62.6 ± 10.3 years, with 27.1% female. In univariate analysis, each 1 mmol/L increase in TWAG was associated with a 1.51-fold (95% confidence interval (CI): 1.36-1.68) higher incidence of AKI. After stepwise adjustment for covariates, the odds ratio (OR) remained significant at 1.50 (95% CI: 1.35-1.67). Similarly, glucose CV showed a positive correlation with AKI risk; a 0.1-unit increase in CV was linked to approximately a 44% higher risk. When both TWAG and CV were included simultaneously in the model, each maintained an independent positive association with AKI. Restricted cubic spline analyses revealed a dose-dependent increase in AKI risk with rising TWAG and CV. Subgroup analyses confirmed the positive relationship between TWAG, glucose variability, and AKI risk. Conclusions: Our study reveals an association between TWAG or CV of glucose and AKI in individuals with both CAD and prediabetes. These findings highlight the potential value of continuous glucose monitoring and managing glycemic variability to reduce AKI risk in this population. |
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| Contributed Indexing: | Keywords: Acute kidney injury; coronary artery disease; glucose concentration; glucose variability; prediabetes |
| Substance Nomenclature: | 0 (Blood Glucose) |
| Entry Date(s): | Date Created: 20250903 Date Completed: 20250903 Latest Revision: 20250906 |
| Update Code: | 20250906 |
| PubMed Central ID: | PMC12409916 |
| DOI: | 10.1080/0886022X.2025.2549412 |
| PMID: | 40898846 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Aims: To validate the effectiveness of intensive glycemic control in preventing acute kidney injury (AKI) among patients with coronary artery disease (CAD) and prediabetes.<br />Methods: This investigation employed data from the Prospective Registry of the Current Status of Care for Patients with CAD database. Glycemic control was evaluated using the time-weighted average glucose (TWAG) and the glucose coefficient of variation (CV) for each participant. The primary outcome was AKI occurrence.<br />Results: A total of 2,454 CAD patients with prediabetes were included between January 2022 and June 2023. The mean age was 62.6 ± 10.3 years, with 27.1% female. In univariate analysis, each 1 mmol/L increase in TWAG was associated with a 1.51-fold (95% confidence interval (CI): 1.36-1.68) higher incidence of AKI. After stepwise adjustment for covariates, the odds ratio (OR) remained significant at 1.50 (95% CI: 1.35-1.67). Similarly, glucose CV showed a positive correlation with AKI risk; a 0.1-unit increase in CV was linked to approximately a 44% higher risk. When both TWAG and CV were included simultaneously in the model, each maintained an independent positive association with AKI. Restricted cubic spline analyses revealed a dose-dependent increase in AKI risk with rising TWAG and CV. Subgroup analyses confirmed the positive relationship between TWAG, glucose variability, and AKI risk.<br />Conclusions: Our study reveals an association between TWAG or CV of glucose and AKI in individuals with both CAD and prediabetes. These findings highlight the potential value of continuous glucose monitoring and managing glycemic variability to reduce AKI risk in this population. |
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| ISSN: | 1525-6049 |
| DOI: | 10.1080/0886022X.2025.2549412 |