Efficacy of Transcranial Direct Current Stimulation in Patients with Primary Progressive Aphasia: A Systematic Review and Updated Meta-analysis.
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| Titel: | Efficacy of Transcranial Direct Current Stimulation in Patients with Primary Progressive Aphasia: A Systematic Review and Updated Meta-analysis. |
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| Autoren: | Alhwaishel K; Mansoura Manchester Program, Faculty of Medicine, Mansoura University, Mansoura, Egypt. huwaishell@gmail.com., Gallo Ruelas M; Instituto de Investigación Nutricional (IIN), Lima, Peru., Ahmed AR; Jinnah Medical and Dental College, Karachi, Sindh, Pakistan., Soares VG; Federal University of the Jequitinhonha and Mucuri Valleys, Diamantina, Minas Gerais, Brazil., Koppanatham A; Andhra Medical College, Visakhapatnam, India., Bocanegra-Becerra JE; Academic Department of Surgery, School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru., Weba ETP; State University of Região Tocantina do Maranhão, Imperatriz, Maranhão, Brazil., Punukollu A; Andhra Medical College, Visakhapatnam, India., Kuhar K; Dr Baba Saheb Ambedkar Medical College and Hospital, Delhi, India., de Moraes Mangas G; Fluminense Federal University, Niterói, Brazil., de Oliveira JS; National University of Rosario, Rosario, Argentina., Aldubaisy RA; Mansoura Manchester Program, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Franklin BA; Global Health, Texas Children's Hospital, Feigin Tower, 1102 Bates Ave., FC0630, Houston, Texas, 77030-2399, USA., Dos Santos Mancilha M; Anhembi Morumbi University, São José dos Campos, São Paulo, Brazil., João RB; Internal Medicine Department, Neurology Division, São Vicente de Paulo Charity Hospital, Jundiaí, Brazil. |
| Quelle: | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2025 Nov; Vol. 46 (11), pp. 5805-5817. Date of Electronic Publication: 2025 Aug 26. |
| Publikationsart: | Journal Article; Systematic Review; Meta-Analysis |
| Sprache: | English |
| Info zur Zeitschrift: | Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100959175 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1590-3478 (Electronic) Linking ISSN: 15901874 NLM ISO Abbreviation: Neurol Sci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Milano, Italy : Springer-Verlag Italia, c2000- |
| MeSH-Schlagworte: | Transcranial Direct Current Stimulation*/methods , Aphasia, Primary Progressive*/therapy, Humans ; Randomized Controlled Trials as Topic ; Treatment Outcome |
| Abstract: | Competing Interests: Declarations: The authors declare no conflicts of interest related to the research, authorship, or publication of this scientific paper. No financial or non-financial competing interests influenced the design, conduct, or reporting of the study. Ethical: As this study involved the analysis of secondary data obtained from previously published studies, formal ethics approval was not required. Additionally, since this meta-analysis utilized aggregated data, consent to participate from individual participants and consent for publication were not applicable. Conflict of Interest: This meta-analysis was not directly funded by any specific grant or organization. The authors declare no conflicts of interest or competing interests related to this meta-analysis. All relevant data and material utilized in this meta- analysis are either publicly available or cited appropriately within the manuscript. Each author contributed significantly to the conception, design, analysis, and interpretation of data in this meta-analysis. All authors have reviewed and approved the final manuscript. Background: Primary progressive aphasia (PPA) is a group of dementias characterized by progressive loss of specific language functions with relative sparing of other cognitive domains. Transcranial direct current stimulation (tDCS) has been introduced as a potential therapeutic option for PPA. We aim to evaluate the efficacy of tDCS in improving cognitive and language functions in patients with PPA. Methods: PubMed, Embase, Cochrane Library, and Web of Science were searched up to June 2024 to identify randomized controlled studies (RCTs) comparing tDCS vs sham procedure in patients with PPA. Results: Our analysis encompassed ten RCTs comparing the efficacy of tDCS against sham treatment, with a total of 167 participants. Due to the crossover design implemented in several studies, 94.5% of participants received active tDCS, while 91.1% received the sham intervention. The findings demonstrated significant improvements immediately post-tDCS (SMD 0.29, 95% CI 0.003-0.57, p = 0.05, I2 = 19%) and sustained benefits after two months or more (SMD 0.51, 95% CI 0.10-0.92, p = 0.01, I2 = 11%) in the untrained naming task. Similarly, for the trained naming tasks, significant improvement was observed (SMD 0.96; 95% CI 0.27 to 1.65; p < 0.01; I2 = 0%), even after the end of the tDCS treatment, with effects persisting for up to two months. (SMD 0.64; 95% CI 0.15 to 1.13; p = 0.01; I2 = 8%). However, no significant improvements were observed in cognitive tasks, untrained comprehension, language, and trained semantic tasks. Conclusion: Our findings suggest that tDCS may be efficacious in augmenting naming tasks both acutely and over a prolonged period of up to two months. However, its effects on overall cognitive performance remain inconclusive. Further robust trials are warranted to elucidate its impact on cognitive function. (© 2025. Fondazione Società Italiana di Neurologia.) |
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(PMID: 10.1016/j.conb.2012.10.00223146876) Roncero C, Kniefel H, Service E, Thiel A, Probst S, Chertkow H (2017) Inferior parietal transcranial direct current stimulation with training improves cognition in anomic Alzheimer’s disease and frontotemporal dementia. Alzheimers Dement 3:247–253. https://doi.org/10.1016/j.trci.2017.01.003. (PMID: 10.1016/j.trci.2017.01.003) |
| Contributed Indexing: | Keywords: Aphasia; Brain stimulation; Cognition; Primary progressive aphasia; Transcranial direct current stimulation; Verbal fluency |
| Entry Date(s): | Date Created: 20250826 Date Completed: 20251020 Latest Revision: 20251124 |
| Update Code: | 20251125 |
| DOI: | 10.1007/s10072-025-08344-y |
| PMID: | 40856746 |
| Datenbank: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstract: | Competing Interests: Declarations: The authors declare no conflicts of interest related to the research, authorship, or publication of this scientific paper. No financial or non-financial competing interests influenced the design, conduct, or reporting of the study. Ethical: As this study involved the analysis of secondary data obtained from previously published studies, formal ethics approval was not required. Additionally, since this meta-analysis utilized aggregated data, consent to participate from individual participants and consent for publication were not applicable. Conflict of Interest: This meta-analysis was not directly funded by any specific grant or organization. The authors declare no conflicts of interest or competing interests related to this meta-analysis. All relevant data and material utilized in this meta- analysis are either publicly available or cited appropriately within the manuscript. Each author contributed significantly to the conception, design, analysis, and interpretation of data in this meta-analysis. All authors have reviewed and approved the final manuscript.<br />Background: Primary progressive aphasia (PPA) is a group of dementias characterized by progressive loss of specific language functions with relative sparing of other cognitive domains. Transcranial direct current stimulation (tDCS) has been introduced as a potential therapeutic option for PPA. We aim to evaluate the efficacy of tDCS in improving cognitive and language functions in patients with PPA.<br />Methods: PubMed, Embase, Cochrane Library, and Web of Science were searched up to June 2024 to identify randomized controlled studies (RCTs) comparing tDCS vs sham procedure in patients with PPA.<br />Results: Our analysis encompassed ten RCTs comparing the efficacy of tDCS against sham treatment, with a total of 167 participants. Due to the crossover design implemented in several studies, 94.5% of participants received active tDCS, while 91.1% received the sham intervention. The findings demonstrated significant improvements immediately post-tDCS (SMD 0.29, 95% CI 0.003-0.57, p = 0.05, I2 = 19%) and sustained benefits after two months or more (SMD 0.51, 95% CI 0.10-0.92, p = 0.01, I2 = 11%) in the untrained naming task. Similarly, for the trained naming tasks, significant improvement was observed (SMD 0.96; 95% CI 0.27 to 1.65; p < 0.01; I2 = 0%), even after the end of the tDCS treatment, with effects persisting for up to two months. (SMD 0.64; 95% CI 0.15 to 1.13; p = 0.01; I2 = 8%). However, no significant improvements were observed in cognitive tasks, untrained comprehension, language, and trained semantic tasks.<br />Conclusion: Our findings suggest that tDCS may be efficacious in augmenting naming tasks both acutely and over a prolonged period of up to two months. However, its effects on overall cognitive performance remain inconclusive. Further robust trials are warranted to elucidate its impact on cognitive function.<br /> (© 2025. Fondazione Società Italiana di Neurologia.) |
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| ISSN: | 1590-3478 |
| DOI: | 10.1007/s10072-025-08344-y |